Showing Protein Isovaleryl-CoA dehydrogenase, mitochondrial (BMDBP00428)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 3 metabolites
Identification
BMDB Protein ID BMDBP00428
Secondary Accession Numbers None
Name Isovaleryl-CoA dehydrogenase, mitochondrial
Synonyms Not Available
Gene Name IVD
Protein Type Enzyme
Biological Properties
General Function Lipid transport and metabolism
Specific Function Catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl-CoA to 3-methylbut-2-enoyl-CoA as an intermediate step in the leucine (Leu) catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of other saturated short-chain acyl-CoA thioesters as pentanoyl-CoA, hexenoyl-CoA and butenoyl-CoA.
Pathways
  • (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3
  • Amino-acid degradation
  • Fatty Acid Metabolism
  • L-leucine degradation
  • Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids
  • Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids
  • Valine, Leucine, and Isoleucine Degradation
Reactions
Isovaleryl-CoA + electron-transfer flavoprotein → 3-Methylcrotonyl-CoA + Reduced electron-transfer flavoprotein details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 10
Locus Not Available
SNPs IVD
Gene Sequence 
>1281 bp
ATGGCGACTGCGGCTTGGTTACTGGGTCGGCGCGTGGCGAGCTGGAGGATGCGACCGCCG
CTGCAGTCTCTTGCTGGCCTGATTACCCAGCGGACCAACTCGCTGTTGCCTGTGGACGAT
GCAGTCAATGGGCTGAACGAGGAGCAGAAGCAGCTTCGTCAGACCGTGGCTAAATTCCTT
CAGGAGCATCTAGCCCCCCAGGCCCAGGAGATCGACCAAAGTAATGAGTTCAAGAACCTG
CGAGAGTTTTGGAAGCAGCTGGGGAACCTAGGAGTCTTGGGCATCACAGCCCCTGTTCAG
TACGGTGGTTCTGGCCTGGGCTTCCTGGAAAACGTGCTGGTGATGGAGGAGATATCCCGA
GTGTCTGGAGCAGTGGGGCTCAGTTATGGAGCCCACTCCAACCTCTGTATCAACCAAATT
GTGCGGAATGGAAACGAGACCCAGAAGGAGAAGTACCTCCCCAAGCTGATAAGTGGTGAA
TACATCGGAGCCCTGGCCATGAGTGAGCCCAATGCTGGCTCTGATGTTGTCTCCATGAAG
CTGAAAGCAGAAAAGAAAGGAGATCACTATGTCCTGAATGGCAACAAGTTCTGGATCACC
AATGGTCCTGATGCAGATGTCCTTGTTGTCTATGCCAAGACTGATGTGACTGCTGTGCCA
GCTTCTCGGGGCATCACAGCCTTCATTGTGGAGAAGGGGATGCCGGGCTTCAGCACCTCC
AAGAAGCTGGACAAGCTAGGGATGAGGGGCTCCAATACCTGTGAGCTGGTCTTCGAAGAC
TGCGAGGTTCCTGCTGCCAACATCCTGGGTCACCTAGGTAAGGGCGTCTATGTGCTGATG
AGTGGGCTGGACCTGGAGCGGCTGGTGCTGGCCGGTGGGCCCCTTGGGATCATGCAGGCC
GTCCTCGACCACACTATTCCCTACCTGCACATGAGGGAGGCCTTTGGCCAGAAGATTGGC
CACTTCCAGTTGATGCAGGGGAAGATGGCAGATATGTACACCCGTCTCATGGCCTGTCGT
CAGTACGTCTACAACGTTGCCAAGGCCTGTGATGAGGGCCACTGCACTACCAAGGACTGT
GCAGGGGTGATTCTTTACTCGGCCGAGTGTGCCACACAGGTAGCCCTGGACGGCATCCAG
TGTTTGGGTGGCAATGGCTACATCAACGACTTTCCCATGGGCCGCTTCCTGAGAGATGCC
AAGCTGTATGAGATCGGGGCTGGGACCAGCGAAGTGAGGCGGCTCGTCATCGGCAGAGCT
TTCAATGCAGACTTCCACTAA
Protein Properties
Number of Residues 426
Molecular Weight 46498.0
Theoretical pI 7.47
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence 
>Isovaleryl-CoA dehydrogenase, mitochondrial
MATAAWLLGRRVASWRMRPPLQSLAGLITQRTNSLLPVDDAVNGLNEEQKQLRQTVAKFL
QEHLAPQAQEIDQSNEFKNLREFWKQLGNLGVLGITAPVQYGGSGLGFLENVLVMEEISR
VSGAVGLSYGAHSNLCINQIVRNGNETQKEKYLPKLISGEYIGALAMSEPNAGSDVVSMK
LKAEKKGDHYVLNGNKFWITNGPDADVLVVYAKTDVTAVPASRGITAFIVEKGMPGFSTS
KKLDKLGMRGSNTCELVFEDCEVPAANILGHLGKGVYVLMSGLDLERLVLAGGPLGIMQA
VLDHTIPYLHMREAFGQKIGHFQLMQGKMADMYTRLMACRQYVYNVAKACDEGHCTTKDC
AGVILYSAECATQVALDGIQCLGGNGYINDFPMGRFLRDAKLYEIGAGTSEVRRLVIGRA
FNADFH
GenBank ID Protein AAI02837.1
UniProtKB/Swiss-Prot ID Q3SZI8
UniProtKB/Swiss-Prot Entry Name IVD_BOVIN
PDB IDs
GenBank Gene ID BC102836
GeneCard ID IVD
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available