Showing Protein cGMP-specific 3',5'-cyclic phosphodiesterase (BMDBP00434)
| Identification | |||
|---|---|---|---|
| BMDB Protein ID | BMDBP00434 | ||
| Secondary Accession Numbers | None | ||
| Name | cGMP-specific 3',5'-cyclic phosphodiesterase | ||
| Synonyms | Not Available | ||
| Gene Name | PDE5A | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Involved in 3',5'-cyclic-GMP phosphodiesterase activity | ||
| Specific Function | Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:8530505). Specifically regulates nitric-oxide-generated cGMP (By similarity). | ||
| Pathways |
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| Reactions |
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 6 | ||
| Locus | Not Available | ||
| SNPs | PDE5A | ||
| Gene Sequence |
>2598 bp ATGGAGAGGGCCGGCCCCGGCTCCGCGCGGCCGCAACAGCAATGGGACCAGGACTCGGTC GAAGCGTGGCTGGACGATCACTGGGACTTTACCTTCTCTTACTTTGTTAGGAAAGGCACC AGAGAAATGGTCAACGCATGGTTTGCTGAGAGAGTTCACACCATTCCTGTGTGCAAGGAA GGAATCAAGGGCCACACGGAATCCTGCTCTTGCCCCTTGCAGCCAAGTCCCCGTGCAGAG AGCAGTGTCCCTGGAACACCAACCAGGAAGATCTCTGCCTCTGAATTCGATCGGCCGCTT AGACCCATCGTTATCAAGGATTCTGAGGGAACTGTGAGCTTCCTCTCTGACTCAGACAAG AAGGAACAGATGCCTCTAACCTCCCCACGGTTTGATAATGATGAAGGGGACCAGTGCTCG AGACTCTTGGAATTAGTGAAAGATATTTCTAGTCACTTGGATGTCACAGCCTTATGTCAC AAAATTTTCTTGCACATCCATGGACTCATCTCCGCCGACCGCTACTCCTTATTCCTCGTC TGTGAGGACAGCTCCAACGACAAGTTTCTTATCAGCCGCCTCTTTGATGTTGCAGAAGGT TCAACACTGGAAGAAGCTTCAAACAACTGCATCCGCTTAGAGTGGAACAAAGGCATCGTG GGACACGTGGCCGCTTTTGGCGAGCCCTTGAACATCAAAGACGCCTATGAGGATCCTCGA TTCAATGCAGAAGTTGACCAAATTACAGGCTACAAGACACAAAGTATTCTTTGTATGCCA ATTAAGAATCATAGGGAAGAGGTTGTTGGTGTAGCCCAGGCCATCAACAAGAAATCAGGA AATGGTGGGACATTCACTGAAAAAGACGAAAAGGACTTTGCTGCTTACTTGGCATTTTGT GGAATTGTTCTTCATAATGCTCAACTCTATGAGACTTCACTGCTGGAGAACAAGAGAAAT CAGGTGCTGCTTGACCTTGCTAGCTTAATTTTTGAAGAACAACAATCATTAGAAGTAATT CTAAAGAAAATAGCTGCCACTATTATCTCTTTCATGCAGGTGCAGAAATGCACCATTTTC ATAGTGGATGAAGATTGCTCCGATTCTTTTTCTAGTGTGTTTCACATGGAGTGTGAGGAA TTAGAAAAATCGTCAGATACTTTAACACGGGAACGTGATGCAAACAGAATCAATTACATG TATGCTCAGTATGTCAAAAATACCATGGAACCACTTAATATCCCAGACGTCAGTAAGGAC AAAAGATTTCCCTGGACAAATGAAAACATGGGAAATATAAACCAGCAGTGCATTAGAAGT TTGCTTTGTACACCTATAAAAAATGGAAAGAAGAACAAAGTGATAGGGGTTTGCCAACTT GTTAATAAGATGGAGGAAACCACTGGCAAAGTTAAGGCTTTCAACCGCAACGATGAACAG TTTCTGGAAGCTTTCGTCATCTTTTGTGGCTTGGGGATCCAGAACACACAGATGTACGAA GCAGTGGAGAGAGCCATGGCCAAGCAAATGGTCACGTTAGAGGTTCTGTCTTATCATGCT TCAGCTGCAGAGGAAGAAACCAGAGAGCTGCAGTCCTTAGCGGCTGCTGTGGTACCATCT GCCCAGACCCTTAAAATCACTGACTTCAGCTTCAGCGACTTTGAGCTGTCTGACCTGGAA ACAGCACTGTGCACAATCCGGATGTTCACTGACCTCAACCTTGTGCAGAACTTCCAGATG AAACATGAGGTCCTTTGCAAGTGGATTTTAAGTGTGAAGAAGAACTATCGGAAGAACGTC GCCTATCATAATTGGAGACATGCCTTTAATACAGCTCAGTGCATGTTTGCGGCACTAAAA GCAGGCAAAATTCAGAAGAGGCTGACGGACCTGGAGATACTTGCACTGCTGATTGCTGCC TTAAGCCATGATCTGGATCACCGTGGTGTCAATAACTCATACATACAGCGAAGTGAACAC CCACTTGCTCAGCTCTACTGCCATTCAATCATGGAGCATCATCATTTTGATCAGTGCCTG ATGATCCTTAATAGTCCTGGCAATCAGATTCTCAGTGGCCTCTCCATTGAAGAGTATAAG ACCACCCTGAAGATCATCAAGCAAGCTATTTTAGCCACAGACCTAGCACTGTACATAAAG AGACGAGGAGAATTTTTTGAACTTATAATGAAAAATCAATTCAATTTGGAAGATCCTCAT CAAAAGGAGTTGTTTTTAGCGATGCTGATGACAGCTTGTGATCTTTCTGCAATTACAAAA CCCTGGCCTATTCAACAACGGATAGCAGAACTTGTTGCCACTGAATTTTTTGACCAAGGA GATAGAGAGAGGAAAGAACTCAACATAGAGCCCGCTGATCTAATGAACCGGGAGAAGAAA AACAAAATCCCAAGTATGCAAGTTGGATTCATAGATGCCATCTGCTTGCAACTGTATGAG GCCTTGACCCATGTGTCGGAGGACTGTTTCCCTTTGCTGGACGGCTGCAGAAAGAACAGG CAGAAATGGCAGGCTCTTGCAGAACAGCAGGAGAAGACACTGATCAATGGTGAAAGCAGC CAGACCAAGCGGAACTGA |
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| Protein Properties | |||
| Number of Residues | 865 | ||
| Molecular Weight | 98627.0 | ||
| Theoretical pI | 5.8 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions | Not Available | ||
| Protein Sequence |
>cGMP-specific 3',5'-cyclic phosphodiesterase MERAGPGSARPQQQWDQDSVEAWLDDHWDFTFSYFVRKGTREMVNAWFAERVHTIPVCKE GIKGHTESCSCPLQPSPRAESSVPGTPTRKISASEFDRPLRPIVIKDSEGTVSFLSDSDK KEQMPLTSPRFDNDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLV CEDSSNDKFLISRLFDVAEGSTLEEASNNCIRLEWNKGIVGHVAAFGEPLNIKDAYEDPR FNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFC GIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIF IVDEDCSDSFSSVFHMECEELEKSSDTLTRERDANRINYMYAQYVKNTMEPLNIPDVSKD KRFPWTNENMGNINQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEETTGKVKAFNRNDEQ FLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPS AQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCKWILSVKKNYRKNV AYHNWRHAFNTAQCMFAALKAGKIQKRLTDLEILALLIAALSHDLDHRGVNNSYIQRSEH PLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIK RRGEFFELIMKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQG DRERKELNIEPADLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNR QKWQALAEQQEKTLINGESSQTKRN |
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| External Links | |||
| GenBank ID Protein | AAB00990.1 | ||
| UniProtKB/Swiss-Prot ID | Q28156 | ||
| UniProtKB/Swiss-Prot Entry Name | PDE5A_BOVIN | ||
| PDB IDs | |||
| GenBank Gene ID | L16545 | ||
| GeneCard ID | PDE5A | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||