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| Identification |
|---|
| BMDB Protein ID
| BMDBP00434 |
| Secondary Accession Numbers
| None |
| Name
| cGMP-specific 3',5'-cyclic phosphodiesterase |
| Synonyms
|
Not Available
|
| Gene Name
| PDE5A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in 3',5'-cyclic-GMP phosphodiesterase activity |
| Specific Function
| Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:8530505). Specifically regulates nitric-oxide-generated cGMP (By similarity). |
| Pathways
|
- 3',5'-cyclic GMP degradation
- GMP from 3',5'-cyclic GMP: step 1/1
- Purine Metabolism
|
| Reactions
|
| Guanosine 2',3'-cyclic phosphate + Water → Guanosine monophosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| Not Available |
| SNPs
| PDE5A |
| Gene Sequence
|
>2598 bp
ATGGAGAGGGCCGGCCCCGGCTCCGCGCGGCCGCAACAGCAATGGGACCAGGACTCGGTC
GAAGCGTGGCTGGACGATCACTGGGACTTTACCTTCTCTTACTTTGTTAGGAAAGGCACC
AGAGAAATGGTCAACGCATGGTTTGCTGAGAGAGTTCACACCATTCCTGTGTGCAAGGAA
GGAATCAAGGGCCACACGGAATCCTGCTCTTGCCCCTTGCAGCCAAGTCCCCGTGCAGAG
AGCAGTGTCCCTGGAACACCAACCAGGAAGATCTCTGCCTCTGAATTCGATCGGCCGCTT
AGACCCATCGTTATCAAGGATTCTGAGGGAACTGTGAGCTTCCTCTCTGACTCAGACAAG
AAGGAACAGATGCCTCTAACCTCCCCACGGTTTGATAATGATGAAGGGGACCAGTGCTCG
AGACTCTTGGAATTAGTGAAAGATATTTCTAGTCACTTGGATGTCACAGCCTTATGTCAC
AAAATTTTCTTGCACATCCATGGACTCATCTCCGCCGACCGCTACTCCTTATTCCTCGTC
TGTGAGGACAGCTCCAACGACAAGTTTCTTATCAGCCGCCTCTTTGATGTTGCAGAAGGT
TCAACACTGGAAGAAGCTTCAAACAACTGCATCCGCTTAGAGTGGAACAAAGGCATCGTG
GGACACGTGGCCGCTTTTGGCGAGCCCTTGAACATCAAAGACGCCTATGAGGATCCTCGA
TTCAATGCAGAAGTTGACCAAATTACAGGCTACAAGACACAAAGTATTCTTTGTATGCCA
ATTAAGAATCATAGGGAAGAGGTTGTTGGTGTAGCCCAGGCCATCAACAAGAAATCAGGA
AATGGTGGGACATTCACTGAAAAAGACGAAAAGGACTTTGCTGCTTACTTGGCATTTTGT
GGAATTGTTCTTCATAATGCTCAACTCTATGAGACTTCACTGCTGGAGAACAAGAGAAAT
CAGGTGCTGCTTGACCTTGCTAGCTTAATTTTTGAAGAACAACAATCATTAGAAGTAATT
CTAAAGAAAATAGCTGCCACTATTATCTCTTTCATGCAGGTGCAGAAATGCACCATTTTC
ATAGTGGATGAAGATTGCTCCGATTCTTTTTCTAGTGTGTTTCACATGGAGTGTGAGGAA
TTAGAAAAATCGTCAGATACTTTAACACGGGAACGTGATGCAAACAGAATCAATTACATG
TATGCTCAGTATGTCAAAAATACCATGGAACCACTTAATATCCCAGACGTCAGTAAGGAC
AAAAGATTTCCCTGGACAAATGAAAACATGGGAAATATAAACCAGCAGTGCATTAGAAGT
TTGCTTTGTACACCTATAAAAAATGGAAAGAAGAACAAAGTGATAGGGGTTTGCCAACTT
GTTAATAAGATGGAGGAAACCACTGGCAAAGTTAAGGCTTTCAACCGCAACGATGAACAG
TTTCTGGAAGCTTTCGTCATCTTTTGTGGCTTGGGGATCCAGAACACACAGATGTACGAA
GCAGTGGAGAGAGCCATGGCCAAGCAAATGGTCACGTTAGAGGTTCTGTCTTATCATGCT
TCAGCTGCAGAGGAAGAAACCAGAGAGCTGCAGTCCTTAGCGGCTGCTGTGGTACCATCT
GCCCAGACCCTTAAAATCACTGACTTCAGCTTCAGCGACTTTGAGCTGTCTGACCTGGAA
ACAGCACTGTGCACAATCCGGATGTTCACTGACCTCAACCTTGTGCAGAACTTCCAGATG
AAACATGAGGTCCTTTGCAAGTGGATTTTAAGTGTGAAGAAGAACTATCGGAAGAACGTC
GCCTATCATAATTGGAGACATGCCTTTAATACAGCTCAGTGCATGTTTGCGGCACTAAAA
GCAGGCAAAATTCAGAAGAGGCTGACGGACCTGGAGATACTTGCACTGCTGATTGCTGCC
TTAAGCCATGATCTGGATCACCGTGGTGTCAATAACTCATACATACAGCGAAGTGAACAC
CCACTTGCTCAGCTCTACTGCCATTCAATCATGGAGCATCATCATTTTGATCAGTGCCTG
ATGATCCTTAATAGTCCTGGCAATCAGATTCTCAGTGGCCTCTCCATTGAAGAGTATAAG
ACCACCCTGAAGATCATCAAGCAAGCTATTTTAGCCACAGACCTAGCACTGTACATAAAG
AGACGAGGAGAATTTTTTGAACTTATAATGAAAAATCAATTCAATTTGGAAGATCCTCAT
CAAAAGGAGTTGTTTTTAGCGATGCTGATGACAGCTTGTGATCTTTCTGCAATTACAAAA
CCCTGGCCTATTCAACAACGGATAGCAGAACTTGTTGCCACTGAATTTTTTGACCAAGGA
GATAGAGAGAGGAAAGAACTCAACATAGAGCCCGCTGATCTAATGAACCGGGAGAAGAAA
AACAAAATCCCAAGTATGCAAGTTGGATTCATAGATGCCATCTGCTTGCAACTGTATGAG
GCCTTGACCCATGTGTCGGAGGACTGTTTCCCTTTGCTGGACGGCTGCAGAAAGAACAGG
CAGAAATGGCAGGCTCTTGCAGAACAGCAGGAGAAGACACTGATCAATGGTGAAAGCAGC
CAGACCAAGCGGAACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 865 |
| Molecular Weight
| 98627.0 |
| Theoretical pI
| 5.8 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>cGMP-specific 3',5'-cyclic phosphodiesterase
MERAGPGSARPQQQWDQDSVEAWLDDHWDFTFSYFVRKGTREMVNAWFAERVHTIPVCKE
GIKGHTESCSCPLQPSPRAESSVPGTPTRKISASEFDRPLRPIVIKDSEGTVSFLSDSDK
KEQMPLTSPRFDNDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLV
CEDSSNDKFLISRLFDVAEGSTLEEASNNCIRLEWNKGIVGHVAAFGEPLNIKDAYEDPR
FNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFC
GIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIF
IVDEDCSDSFSSVFHMECEELEKSSDTLTRERDANRINYMYAQYVKNTMEPLNIPDVSKD
KRFPWTNENMGNINQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEETTGKVKAFNRNDEQ
FLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPS
AQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCKWILSVKKNYRKNV
AYHNWRHAFNTAQCMFAALKAGKIQKRLTDLEILALLIAALSHDLDHRGVNNSYIQRSEH
PLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIK
RRGEFFELIMKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQG
DRERKELNIEPADLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNR
QKWQALAEQQEKTLINGESSQTKRN
|
| External Links |
|---|
| GenBank ID Protein
| AAB00990.1 |
| UniProtKB/Swiss-Prot ID
| Q28156 |
| UniProtKB/Swiss-Prot Entry Name
| PDE5A_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| L16545 |
| GeneCard ID
| PDE5A |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
