| Identification |
|---|
| BMDB Protein ID
| BMDBP00442 |
| Secondary Accession Numbers
| None |
| Name
| Adenylate cyclase type 1 |
| Synonyms
|
Not Available
|
| Gene Name
| ADCY1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Signal transduction mechanisms |
| Specific Function
| Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:2472670, PubMed:2022671. PubMed:19029295). Mediates responses to increased cellular Ca(2+)/calmodulin levels (PubMed:2022671, PubMed:19029295). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity). |
| Pathways
|
|
| Reactions
|
| Adenosine triphosphate → Cyclic AMP + Pyrophosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| Not Available |
| SNPs
| ADCY1 |
| Gene Sequence
|
>3405 bp
ATGGCGGGGGCGCCGCGCGGCCGAGGCGGCGGCGGAGGCGGAGGCGGCGCGGGCGAGTCT
GGGGGCGCCGAGCGGGCGGCGGGGCCGGGCGGCCGGCGCGGGCTGCGGGCGTGCGATGAG
GAGTTCGCGTGCCCCGAGCTGGAGGCGCTGTTCCGCGGCTACACGCTGCGGCTGGAGCAG
GCGGCGACGCTGAAGGCGCTGGCCGTGCTCAGCCTGCTGGCGGGCGCGCTGGCCCTGGCC
GAGCTGCTGGGCGCGCCGGGGCCCGCGCCCGGCCTGGCTAAGGGCTCGCACCCCGTGCAC
TGCGTGCTCTTCCTGGCGCTGCTCGTGGTCACCAACGTCCGCTCGCTGCAGGTGCCCCAG
CTGCAGCAGGTCGGCCAGCTCGCGCTGCTCTTCAGCCTCACCTTCGCTCTGCTGTGCTGT
CCCTTCGCGCTCGGCGGCCCCGCCGGTGCCCACGCCGGGGCGGCAGCGGTGCCGGCGACA
GCCGATCAGGGAGTCTGGCAGCTCCTTTTGGTCACCTTCGTGTCCTATGCCCTGCTGCCC
GTGCGCAGCCTGCTGGCCATCGGCTTCGGGCTCGTGGTGGCCGCCTCGCACTTGCTGGTC
ACGGCTACGTTGGTCCCCGCCAAGCGCCCACGTCTCTGGAGAACGCTGGGTGCCAACGCT
CTGCTCTTCCTCGGTGTGAACGTGTATGGCATCTTCGTGAGGATCCTGGCTGAGCGCGCC
CAGAGGAAGGCCTTCCTGCAGGCCCGGAACTGCATTGAGGACCGGCTGAGGCTGGAGGAT
GAGAATGAGAAGCAGGAGCGGCTGCTCATGAGCCTCCTGCCTCGGAATGTTGCCATGGAG
ATGAAGGAGGACTTCCTGAAGCCCCCTGAGAGGATTTTCCACAAGATTTACATCCAGCGG
CATGACAACGTGAGCATCCTCTTTGCAGACATCGTGGGCTTCACAGGCTTGGCGTCACAG
TGCACGGCCCAGGAGCTGGTGAAACTCCTCAATGAGCTCTTCGGGAAGTTTGACGAGCTG
GCCACAGAGAACCACTGCCGCCGCATCAAGATCCTGGGAGATTGCTACTACTGCGTGTCT
GGCCTCACTCAGCCCAAGACTGACCACGCCCACTGCTGTGTGGAGATGGGCCTGGACATG
ATCGACACCATCACGTCCGTGGCTGAGGCCACTGAGGTGGACTTGAACATGCGTGTGGGG
CTGCACACCGGCAGGGTCCTCTGCGGGGTCCTGGGCCTGCGTAAGTGGCAGTATGATGTG
TGGTCCAACGACGTGACCCTGGCCAACGTCATGGAGGCTGCCGGCCTGCCTGGGAAGGTT
CACATCACAAAGACCACCCTGGCGTGCCTGAATGGTGACTATGAGGTGGAGCCGGGACAC
GGACACGAGAGGAACAGTTTTCTGAAAACTCATAACATTGAGACCTTTTTTATTGTGCCC
TCGCATCGGCGAAAGATATTTCCAGGGCTGATTCTCTCAGACATAAAACCGGCCAAGAGG
ATGAAGTTCAAGACCGTGTGCTACCTGCTGGTGCAGCTCATGCACTGCCGGAAGATGTTC
AAGGCCGAGATCCCTTTCTCCAACGTCATGACCTGTGAGGATGACGACAAGCGGAGGGCA
CTGAGAACAGCCTCGGAAAAACTCAGAAACCGCTCGTCTTTCTCTACAAACGTTGTCCAA
ACCACCCCCGGCACACGTGTCAACAGGTACATCGGCCGCCTCCTGGAAGCCCGCCAGATG
GAGCTGGAGATGGCAGACCTGAACTTCTTCACCCTGAAGTACAAGCAAGCTGAGCGAGAG
CGAAAGTACCACCAGCTTCAGGACGAGTATTTCACCAGCGCCGTGGTTCTGGCTCTCATT
CTGGCCGCCTTATTCGGCCTTGTCTACCTTCTAATAATCCCACAGAGTGTGGCTGTCCTG
CTCCTGCTGGTGTTCTGCATCTGCTTCCTGGTGGCCTGTGTCCTGTACCTACACATCACC
CGGGTCCAGTGTTTTCCAGGGTGCCTGACCATCCAGATCCGCACCGTCTTGTGCATCTTC
ATCGTGGTCTTAATCTACTCTGTGGCCCAAGGCTGTGTGGTGGGCTGCCTGCCTTGGTCC
TGGAGCTCCAGTCCCAACGGGTCCCTGGTGGTCCTGTCTTCTGGGGGCCGGGACCCAGTG
CTGCCTGTCCCGCCCTGCGAGTCTGCGCCCCATGCCCTGCTGTGCGGCCTCGTGGGCACC
CTCCCGCTGGCCATATTCCTGCGGGTCTCCTCCTTGCCAAAAATGATCCTGCTCGCCGTG
CTCACCACCTCCTACATCCTCGTCCTGGAGCTCAGCGGGTACACGAAGGCCATGGGGGCC
GGTGCCATCTCAGGGCGCAGCTTCGAGCCGATCATGGCCATCCTGCTATTCTCGTGCACG
CTGGCCCTGCACGCCCGGCAGGTGGATGTCAAGCTGCGGCTGGACTACCTCTGGGCGGCC
CAGGCAGAGGAGGAGCGGGATGACATGGAGAAAGTGAAGCTGGACAACAAGAGGATTCTC
TTCAACCTCCTGCCAGCCCACGTTGCCCAGCACTTCCTAATGTCCAACCCTCGCAACATG
GACCTGTATTACCAGTCATACTCGCAGGTGGGGGTCATGTTTGCATCCATCCCCAACTTC
AATGACTTCTACATCGAGCTGGATGGCAACAACATGGGGGTGGAATGTCTACGCCTTCTG
AATGAGATCATCGCTGACTTTGATGAGCTCATGGACAAAGACTTTTACAAGGACCTAGAG
AAGATCAAGACCATTGGGAGCACGTACATGGCTGCTGTGGGGCTGGCGCCCACTGCTGGG
ACCAAGGCTAAGAAGTGCATCTCCTCCCACCTCAGCACGTTGGCAGATTTTGCCATCGAG
ATGTTTGATGTCCTGGATGAGATCAACTACCAGTCTTATAACGACTTTGTGCTCCGTGTT
GGCATCAATGTTGGCCCCGTGGTGGCTGGAGTGATCGGGGCTCGCAGGCCGCAGTATGAC
ATTTGGGGGAACACGGTCAATGTGGCCAGTCGGATGGACAGTACCGGCGTCCAGGGCAGG
ATCCAGGTCACAGAGGAAGTTCACCGGCTGCTGCGGCGGGGTTCCTACCGCTTCGTGTGC
CGAGGCAAAGTCAGTGTCAAGGGCAAGGGTGAGATGCTGACATACTTCCTGGAAGGCAGG
ACCGATGGAAATGGCTCCCAAACCAGGTCCCTGAACTCAGAGCGGAAAATGTATCCTTTC
GGAAGAGCTGGCCTCCAGACCAGACTGGCTGCGGGTCACCCCCCGGTACCTCCTGCAGCC
GGCCTCCCAGTTGGAGCTGGGCCAGGGGCTCTGCAGGGCTCGGGGCTTGCCCCAGGCCCC
CCAGGCCAACACCTGCCCCCTGGAGCCTCTGGGAAGGAGGCTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1134 |
| Molecular Weight
| 123979.0 |
| Theoretical pI
| 8.42 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 66-86
- 90-110
- 127-147
- 154-174
- 184-204
- 216-236
- 613-633
- 637-657
- 676-696
- 727-747
- 755-775
- 777-797
|
| Protein Sequence
|
>Adenylate cyclase type 1
MAGAPRGRGGGGGGGGAGESGGAERAAGPGGRRGLRACDEEFACPELEALFRGYTLRLEQ
AATLKALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCVLFLALLVVTNVRSLQVPQ
LQQVGQLALLFSLTFALLCCPFALGGPAGAHAGAAAVPATADQGVWQLLLVTFVSYALLP
VRSLLAIGFGLVVAASHLLVTATLVPAKRPRLWRTLGANALLFLGVNVYGIFVRILAERA
QRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQR
HDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVS
GLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDV
WSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGHGHERNSFLKTHNIETFFIVP
SHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRA
LRTASEKLRNRSSFSTNVVQTTPGTRVNRYIGRLLEARQMELEMADLNFFTLKYKQAERE
RKYHQLQDEYFTSAVVLALILAALFGLVYLLIIPQSVAVLLLLVFCICFLVACVLYLHIT
RVQCFPGCLTIQIRTVLCIFIVVLIYSVAQGCVVGCLPWSWSSSPNGSLVVLSSGGRDPV
LPVPPCESAPHALLCGLVGTLPLAIFLRVSSLPKMILLAVLTTSYILVLELSGYTKAMGA
GAISGRSFEPIMAILLFSCTLALHARQVDVKLRLDYLWAAQAEEERDDMEKVKLDNKRIL
FNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLL
NEIIADFDELMDKDFYKDLEKIKTIGSTYMAAVGLAPTAGTKAKKCISSHLSTLADFAIE
MFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGR
IQVTEEVHRLLRRGSYRFVCRGKVSVKGKGEMLTYFLEGRTDGNGSQTRSLNSERKMYPF
GRAGLQTRLAAGHPPVPPAAGLPVGAGPGALQGSGLAPGPPGQHLPPGASGKEA
|
| External Links |
|---|
| GenBank ID Protein
| AAA79957.1 |
| UniProtKB/Swiss-Prot ID
| P19754 |
| UniProtKB/Swiss-Prot Entry Name
| ADCY1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| M25579 |
| GeneCard ID
| ADCY1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
