| Identification |
|---|
| BMDB Protein ID
| BMDBP00443 |
| Secondary Accession Numbers
| None |
| Name
| Poly(A)-specific ribonuclease PARN |
| Synonyms
|
Not Available
|
| Gene Name
| PARN |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in magnesium ion binding |
| Specific Function
| 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (By similarity). Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails (By similarity) (PubMed:10698948, PubMed:9736620). Also able to recognize poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 25 |
| Locus
| Not Available |
| SNPs
| PARN |
| Gene Sequence
|
>1917 bp
ATGGAGATAATCAGGAGCAATTTTAAGAGTAATCTTCACAAAGTGTACCAGGCCATAGAG
GAGGCCGACTTCTTCGCCATCGATGGGGAGTTCTCAGGAATCAGCGATGGACCTTCAGTC
ACCGCATTAACAAATGGTTTTGACACTCCAGAAGAAAGGTATCAGAAGCTTAAAAAGCAT
TCCATGGACTTTTTGCTGTTTCAGTTTGGCCTTTGCACTTTTAAGTATGACTACACAGAT
TCAAAGTATATAACAAAGTCTTTTAACTTCTATGTTTTCCCGAAACCCTTCAATAGATCC
TCACCAGATGTCAAATTTGTTTGTCAGAGCTCAAGCATTGACTTTCTAGCAAGCCAAGGA
TTTGATTTTAATAAAGTTTTTCGCAACGGAATTCCGTACTTAAACCAGGAAGAAGAAAGA
CAGTTAAGAGAGCAGTATGATGAGAAGCGTTCACAGTCCAACGGTGCAGGTGCTCTGTCC
TACACGTCTCCCAACACTTCAAAGTGTCCCGTGACAATTCCTGACGATCAGAAGAAGTTT
ATTGACCAAGTGGTAGAGAAAATAGAAGATTTATTACAAAGTGAAGAAAACAAGAACTTG
GATTTAGAGCCGTGTACTGGGTTCCAAAGAAAACTGATATATCAGACTTTGAGCTGGAAG
TATCCCAAAGGCATTCATGTTGAGACTTTAGAAACCGAAAAGAAAGAGCGATATATTGTT
ATCAGCAAAGTAGATGAAGAAGAACGCAAAAGAAGAGAGCAACAGAAACATGCTAAGGAA
CAGGAAGAACTGAATGATGCTGTGGGATTTTCTAGAGTCATTCATGCCATTGCTAATTCG
GGGAAGCTTGTCATTGGACACAACATGCTCTTGGATGTCATGCACACGGTTCATCAGTTC
TACTGCCCTCTGCCTGCGGACTTAAATGAATTTAAGGAGATGACAACATGTGTTTTCCCC
AGGCTCTTGGATACAAAATTGATGGCCAGCACACAACCTTTTAAGGATATCATTAACAAC
ACATCCCTTGCAGAATTGGAAAAGCGGTTAAAAGAGACACCTTTCAACCCTCCTAAAGTT
GAAAGTGCAGAAGGCTTTCCAAGTTATGACACGGCTTCTGAACAGCTCCACGAGGCAGGC
TATGATGCTTATATCACAGGACTGTGTTTCATCTCCATGGCCAACTACCTAGGTTCTTTT
CTTAGTCCTCCAAAGAGTCATGTGTCTGCCAGATCAAAACTCATCGAACCTTTTTTTAAC
AAGTTGTTTCTTATGAGAGTCATGGATATCCCCTATCTAAACTTGGAAGGACCAGACTTG
CAGCCTAAACGTGATCACGTCCTCCACGTGACATTCCCCAAAGAATGGAAAACCAGCGAC
CTTTACCAGCTTTTCAGTGCCTTTGGTAACATTCAGATATCTTGGATTGATGACACATCA
GCATTTGTTTCTCTCAGCCAACCTGAACAAGTGCCGATTGCTGTCAATACCAGCAAGTAT
GCAGAGAGCTATCGCATCCAGACCTACGCTGACTATGTCGGGAAAAAACGAGAGGAGAAG
CAGATGAAGAGAAAGTGGACAGAAGATAGTTGGAAGGAGGTTGAGCCAAAGCGGCTAAAC
ACGCAGTGTGGCTCCTACAGTTTGCAGAATCACCATTACCACGCCAACAGTCTCACAGCC
ACCAGCACAGTAGGAAAGAGAAACCTGAGTCCCAGTCGAGCAGAAGCCGGCCTGGAGGCC
CGAGCATCGGGGGAGATTTCTGACACTGAGCTTGAGCAGACAGATCCCTGTGCAGAACCC
CTCTCAGAGGGAAGGAAAAAGGCCAAGAAACTAAAAAGGATGAAGAAGGACCTTTCTCCA
ACAGGAAGCATCTCAGACAGCTCGGCCAAGCTCTTCGAAGTCCCCGACACATGGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 638 |
| Molecular Weight
| 73182.0 |
| Theoretical pI
| 6.47 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Poly(A)-specific ribonuclease PARN
MEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVTALTNGFDTPEERYQKLKKH
SMDFLLFQFGLCTFKYDYTDSKYITKSFNFYVFPKPFNRSSPDVKFVCQSSSIDFLASQG
FDFNKVFRNGIPYLNQEEERQLREQYDEKRSQSNGAGALSYTSPNTSKCPVTIPDDQKKF
IDQVVEKIEDLLQSEENKNLDLEPCTGFQRKLIYQTLSWKYPKGIHVETLETEKKERYIV
ISKVDEEERKRREQQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQF
YCPLPADLNEFKEMTTCVFPRLLDTKLMASTQPFKDIINNTSLAELEKRLKETPFNPPKV
ESAEGFPSYDTASEQLHEAGYDAYITGLCFISMANYLGSFLSPPKSHVSARSKLIEPFFN
KLFLMRVMDIPYLNLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWIDDTS
AFVSLSQPEQVPIAVNTSKYAESYRIQTYADYVGKKREEKQMKRKWTEDSWKEVEPKRLN
TQCGSYSLQNHHYHANSLTATSTVGKRNLSPSRAEAGLEARASGEISDTELEQTDPCAEP
LSEGRKKAKKLKRMKKDLSPTGSISDSSAKLFEVPDTW
|
| External Links |
|---|
| GenBank ID Protein
| AAI50016.1 |
| UniProtKB/Swiss-Prot ID
| P69341 |
| UniProtKB/Swiss-Prot Entry Name
| PARN_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC150015 |
| GeneCard ID
| PARN |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
