Showing Protein Poly(A)-specific ribonuclease PARN (BMDBP00443)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00443 |
| Secondary Accession Numbers | None |
| Name | Poly(A)-specific ribonuclease PARN |
| Synonyms | Not Available |
| Gene Name | PARN |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in magnesium ion binding |
| Specific Function | 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (By similarity). Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails (By similarity) (PubMed:10698948, PubMed:9736620). Also able to recognize poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 25 |
| Locus | Not Available |
| SNPs | PARN |
| Gene Sequence |
>1917 bp ATGGAGATAATCAGGAGCAATTTTAAGAGTAATCTTCACAAAGTGTACCAGGCCATAGAG GAGGCCGACTTCTTCGCCATCGATGGGGAGTTCTCAGGAATCAGCGATGGACCTTCAGTC ACCGCATTAACAAATGGTTTTGACACTCCAGAAGAAAGGTATCAGAAGCTTAAAAAGCAT TCCATGGACTTTTTGCTGTTTCAGTTTGGCCTTTGCACTTTTAAGTATGACTACACAGAT TCAAAGTATATAACAAAGTCTTTTAACTTCTATGTTTTCCCGAAACCCTTCAATAGATCC TCACCAGATGTCAAATTTGTTTGTCAGAGCTCAAGCATTGACTTTCTAGCAAGCCAAGGA TTTGATTTTAATAAAGTTTTTCGCAACGGAATTCCGTACTTAAACCAGGAAGAAGAAAGA CAGTTAAGAGAGCAGTATGATGAGAAGCGTTCACAGTCCAACGGTGCAGGTGCTCTGTCC TACACGTCTCCCAACACTTCAAAGTGTCCCGTGACAATTCCTGACGATCAGAAGAAGTTT ATTGACCAAGTGGTAGAGAAAATAGAAGATTTATTACAAAGTGAAGAAAACAAGAACTTG GATTTAGAGCCGTGTACTGGGTTCCAAAGAAAACTGATATATCAGACTTTGAGCTGGAAG TATCCCAAAGGCATTCATGTTGAGACTTTAGAAACCGAAAAGAAAGAGCGATATATTGTT ATCAGCAAAGTAGATGAAGAAGAACGCAAAAGAAGAGAGCAACAGAAACATGCTAAGGAA CAGGAAGAACTGAATGATGCTGTGGGATTTTCTAGAGTCATTCATGCCATTGCTAATTCG GGGAAGCTTGTCATTGGACACAACATGCTCTTGGATGTCATGCACACGGTTCATCAGTTC TACTGCCCTCTGCCTGCGGACTTAAATGAATTTAAGGAGATGACAACATGTGTTTTCCCC AGGCTCTTGGATACAAAATTGATGGCCAGCACACAACCTTTTAAGGATATCATTAACAAC ACATCCCTTGCAGAATTGGAAAAGCGGTTAAAAGAGACACCTTTCAACCCTCCTAAAGTT GAAAGTGCAGAAGGCTTTCCAAGTTATGACACGGCTTCTGAACAGCTCCACGAGGCAGGC TATGATGCTTATATCACAGGACTGTGTTTCATCTCCATGGCCAACTACCTAGGTTCTTTT CTTAGTCCTCCAAAGAGTCATGTGTCTGCCAGATCAAAACTCATCGAACCTTTTTTTAAC AAGTTGTTTCTTATGAGAGTCATGGATATCCCCTATCTAAACTTGGAAGGACCAGACTTG CAGCCTAAACGTGATCACGTCCTCCACGTGACATTCCCCAAAGAATGGAAAACCAGCGAC CTTTACCAGCTTTTCAGTGCCTTTGGTAACATTCAGATATCTTGGATTGATGACACATCA GCATTTGTTTCTCTCAGCCAACCTGAACAAGTGCCGATTGCTGTCAATACCAGCAAGTAT GCAGAGAGCTATCGCATCCAGACCTACGCTGACTATGTCGGGAAAAAACGAGAGGAGAAG CAGATGAAGAGAAAGTGGACAGAAGATAGTTGGAAGGAGGTTGAGCCAAAGCGGCTAAAC ACGCAGTGTGGCTCCTACAGTTTGCAGAATCACCATTACCACGCCAACAGTCTCACAGCC ACCAGCACAGTAGGAAAGAGAAACCTGAGTCCCAGTCGAGCAGAAGCCGGCCTGGAGGCC CGAGCATCGGGGGAGATTTCTGACACTGAGCTTGAGCAGACAGATCCCTGTGCAGAACCC CTCTCAGAGGGAAGGAAAAAGGCCAAGAAACTAAAAAGGATGAAGAAGGACCTTTCTCCA ACAGGAAGCATCTCAGACAGCTCGGCCAAGCTCTTCGAAGTCCCCGACACATGGTAA |
| Protein Properties | |
| Number of Residues | 638 |
| Molecular Weight | 73182.0 |
| Theoretical pI | 6.47 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Poly(A)-specific ribonuclease PARN MEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVTALTNGFDTPEERYQKLKKH SMDFLLFQFGLCTFKYDYTDSKYITKSFNFYVFPKPFNRSSPDVKFVCQSSSIDFLASQG FDFNKVFRNGIPYLNQEEERQLREQYDEKRSQSNGAGALSYTSPNTSKCPVTIPDDQKKF IDQVVEKIEDLLQSEENKNLDLEPCTGFQRKLIYQTLSWKYPKGIHVETLETEKKERYIV ISKVDEEERKRREQQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQF YCPLPADLNEFKEMTTCVFPRLLDTKLMASTQPFKDIINNTSLAELEKRLKETPFNPPKV ESAEGFPSYDTASEQLHEAGYDAYITGLCFISMANYLGSFLSPPKSHVSARSKLIEPFFN KLFLMRVMDIPYLNLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWIDDTS AFVSLSQPEQVPIAVNTSKYAESYRIQTYADYVGKKREEKQMKRKWTEDSWKEVEPKRLN TQCGSYSLQNHHYHANSLTATSTVGKRNLSPSRAEAGLEARASGEISDTELEQTDPCAEP LSEGRKKAKKLKRMKKDLSPTGSISDSSAKLFEVPDTW |
| External Links | |
| GenBank ID Protein | AAI50016.1 |
| UniProtKB/Swiss-Prot ID | P69341 |
| UniProtKB/Swiss-Prot Entry Name | PARN_BOVIN |
| PDB IDs | |
| GenBank Gene ID | BC150015 |
| GeneCard ID | PARN |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |