| Identification |
|---|
| BMDB Protein ID
| BMDBP00454 |
| Secondary Accession Numbers
| None |
| Name
| Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| IDH3G |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| X |
| Locus
| Not Available |
| SNPs
| IDH3G |
| Gene Sequence
|
>1179 bp
ATGGCGCTGAAGGTGGCGACGGCCGCGGGCGGCGCTGTGAAGGCAGCGCTCAGGCCGGCC
CTCCTCTGGCGTCCTTGGGAGGTTCTAGGTTCCCACGAGGCCCCCCGGAGGAGCTTCTCA
CAACAAACAATTCCCCCGTCGGCGAAGTATGGTGGGCGGCACACGGTGACCATGATCCCG
GGAGATGGCATTGGGCCAGAGCTCATGCTGCACGTCAAGTCAGTGTTCAGGCATGCATGT
GTGCCTGTGGACTTTGAAGAGGTGCACGTGAGCTCCACCGCGGACGAGGAGGACATCCGC
AATGCCATCATGGCCATCCGTCGGAACCGCGTAGCCCTGAAGGGCAACATTGAAACAAAC
CACAACCTGCCCCCATCCCACAAATCGCGAAACAACATCCTTCGCACCAGCCTGGACCTC
TATGCCAACGTCATCCACTGTAAGAGCCTGCCAGGTGTGGTGACCCGGCATCGGGACATT
GATATCCTCATTGTCCGGGAGAACACAGAGGGCGAGTACAGCAGCCTGGAACACGAGAGT
GTGGCGGGCGTGGTGGAGAGCCTGAAGATCATCACCAAGGCCAAGTCCCTGCGTATTGCT
GAGTACGCCTTCCAACTGGCCCAGGAGAGCGGGCGCAAGAAAGTGACAGCCGTGCACAAG
GCCAACATCATGAAACTGGGCGATGGGCTTTTCCTCCAGTGCTGCAGGGAAGTGGCAGCC
CGCTACCCCCAGATCACCTTTGAGAATATGATTGTGGACAACACCACCATGCAGCTGGTG
TCCCGGCCCCAGCAGTTTGATGTCATGGTGATGCCCAATCTCTATGGCAACATCGTCAAC
AACGTCTGTGCTGGGCTAGTTGGGGGCCCCGGCCTTGTGGCTGGGGCCAACTATGGCCAT
GTGTATGCCGTGTTTGAGACGGCTACAAGGAACACAGGGAAGAGTATTGCCAATAAGAAC
ATTGCCAACCCCACAGCTACACTGCTGGCAAGTTGCATGATGCTCGACCACCTCAAGCTG
CACTCCTATGCCACCTCCATCCGCAAGGCCGTCCTGGCATCCATGGACAATGAAAACATG
CACACCCCAGACATCGGGGGCCAGGGCACCACGTCGGAAGCCATCCAGGACATCATCCGC
CATATCCGTGTCATTAACGGTCGGGCCGTGGAGGCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 392 |
| Molecular Weight
| 42863.0 |
| Theoretical pI
| 9.16 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
MALKVATAAGGAVKAALRPALLWRPWEVLGSHEAPRRSFSQQTIPPSAKYGGRHTVTMIP
GDGIGPELMLHVKSVFRHACVPVDFEEVHVSSTADEEDIRNAIMAIRRNRVALKGNIETN
HNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHRDIDILIVRENTEGEYSSLEHES
VAGVVESLKIITKAKSLRIAEYAFQLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAA
RYPQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGANYGH
VYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSIRKAVLASMDNENM
HTPDIGGQGTTSEAIQDIIRHIRVINGRAVEA
|
| External Links |
|---|
| GenBank ID Protein
| AAX46754.1 |
| UniProtKB/Swiss-Prot ID
| Q58CP0 |
| UniProtKB/Swiss-Prot Entry Name
| IDH3G_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT021907 |
| GeneCard ID
| IDH3G |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
