Showing Protein Adenylate cyclase type 7 (BMDBP00466)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00466 |
| Secondary Accession Numbers |
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| Name | Adenylate cyclase type 7 |
| Synonyms | Not Available |
| Gene Name | ADCY7 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Signal transduction mechanisms |
| Specific Function | Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors. Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 (By similarity). Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13) (By similarity). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex (By similarity). Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 18 |
| Locus | Not Available |
| SNPs | ADCY7 |
| Gene Sequence |
>3291 bp ATGCTCCCCAGGCCGTGGGGTTTCCTGCGTGGACCACTGGGTGTGCCAAGGTGGAGGATG CCAGCCAAGGGGCGCTACTTCCTCAACGAGGGCGAGGAGGGCCCCGACCAGGATGCGCTC TACGAGAAGTACCGCCTCACCAGCCAGCACGGGCCACTCCTGCTCATGCTCCTGTTGGTG GCCATCGCTGCCTGCACCACGCTCATCGTCATCACCTTCAGCTATGGGGACCCCTCCAGA CACCGGGCCGTCCTGGGGACGGCGTTCTTCACGCTCGCCATGTTTGTGCTCCTCTACGCT CTGGTGTACGTTGAGTGCCTCGACCGGCGGGGGCTCAGGATTTCCGCGCTGCTCATCTGG GCCTGCCTTGTGACGCTGGGCTACGTGTTGGTGTTTGATTTCGACTCGCCGAGGAAGGAC ACCTGTGTCTTGGGGCAGGTGCCCTTCTTCCTGTTCGTGGTCTTCGTGGTGTACACGCTG CTGCCCTTCAGCATGTGGGGCGCCGTCACGGCCGGACTCGTCTCCAGCATCTCCCACCTC CTGGTGCTCGCAATGCACCAGGAAGACTTCACCAGCCCTGTGGGGCTGAAGCTGCTGGCC ACTGCGGTGGTCTTCGTGTGCGGGAACCTCACAGGCGCCTTCCACAAGCACCACATGCAG GACGCCTCCCACGACCTCTTCACCTACACAGTGAAGTGCATCCAGATTCGGCGTAAGCTG CGCATCGAGAAGCGCCAGCAGGAGAACCTGCTGCTGTCTGTGCTGCCTGCCCACATCTCC ATGGGCATGAAGCTGGCCATCATCGAGCGGCTCAAGGAGCGCGGGGACCGCCGTTACCTG CCCGACAACAACTTCCACAACCTCTACGTCAAGAGGCACCAGAATGTCAGCATCCTCTAC GCTGACATCGTGGGCTTCACGCGACTGGCCAGTGACTGCTCCCCCAAAGAGCTGGTGGTG GTGCTGAATGAGCTCTTCGGCAAGTTTGACCAGATCGCCAAGGCCAACGAGTGCATGCGG ATTAAGATCCTGGGCGACTGCTACTACTGCGTGTCCGGCTTGCCTGTGTCCCTGCCCAAC CACGCCCGTAACTGTGTGAAGATGGGGCTGGACATGTGTGAGGCCATCAAGCAGGTGCGG GAGGCCACAGGCGTGGACATCAGCATGCGCGTGGGCATCCACTCGGGGAACGTGCTGTGC GGCGTCATCGGGCTGCGCAAGTGGCAGTACGACGTGTGGTCCCACGATGTGTCCCTGGCC AACAGGATGGAGGCGGCCGGAGTCCCTGGCCGGGTGCACATCACAGAGGCGACGCTGAAG CACCTGGACAAGGCGTATGAGGTGGAGGACGGGCACGGGCAGCAGCGGGACCCTTACCTC AAAGAGATGAACATCCGCACCTACCTGGTCATCGACCCCCGGAGCCAGCAGCCGCCCCAG CCCAGCCAGCACAACTCCAAGAACAAGGGGGACGCGACCCTGAAGATGCGGGCGTCCGTG CGCATGACGCGCTACCTGGAGTCCTGGGGGGCGGCTCGCCCCTTCGCGCACCTCAACCAA CGCGAGAGCGTGAGCAGCAGTGAGACCCTTGTGTCCCATGGGCGGAGGCCCAAGGCTGTT CCCCTGAGGCGCCATCGGACCCCTGACAGAAGCGCATCCCCCAAGGGGCGGTCAGAGGAC GACTCATACGATGATGAGATGCTGTCAGCCATCGAGGGGCTCAGCTCTACCAGACCCTGC TGCTCCAAGTCTGATGACTTCTCCACCTTTGGGTCCATCTTCCTGGAGAAGGGCTTCGAG CGAGAGTACCGCCTGGCGCCCATCCCCCGGGTCCGCTACTACTTCGCTTGTGCCAGCCTC GTCTTCGTCTTCATCCTGCTCATCCACGTCTTGCTGTTGTACAGTATGAAGACTCTGGGC GTGTCCTTTGGGCTGGTGGCCTGTGTGCTTGGGCTGGTACTAGGCTTGTGCTTCGCCGAT GTGTTCTTGAGGTGCTGCCCGGCCCTGGGGAAGCTCCGAGCCATTGCCGAGAGCGTGGAG ACGCAGCCCCTGCTGCGGGTGTCCCTGGCCATCCTGACCATCGGCAGCCTGCTCGTCATT GCTGTCGTCAACCTGCCCCTGATGCCCTTCCGGGACCGGGGGCTGACTGCTGGGAACGAG ACGGGCCTGAGGGCTGTGAGCGGCTGGGAGATGAGCCCGTGCTACCTCCTCCCGTACTAC ACCTGCAGCTGCATCCTGGCCTTCATCGCTTGCTCTGTCTTCCTGCGGATGAGCCTGGAG CTGAAGGTCGTGCTGCTGACCGTGGCCTTGGTGGCCTACCTGGTCCTCTTCAACGTCTAC CCGAGCTGGCAGTGGGACTGCTGTGGCCACAGCCTGGGCAACCTCACCGGGACCAATGGC ACCCTCAGCTCCTCATCCTGTTCATGGCATCTGAAGACGATGACCAATTTCTACCTGGTC TTGTTCTACACCACCCTCATCATGCTCTCCAGACAGATTGACTATTATTGCCGCCTGGAC TGTCTGTGGAAGAAGAAGTTCAAGAAGGAACACGAGGAGTTTGAAACAATGGAGAATGTG AACCGCCTTCTTCTAGAGAATGTCCTGCCCGCGCACGTGGCCGCCCACTTCATCGGTGAC AAGTTAAATGAGGACTGGTACCATCAGTCCTACGACTGCGTGTGTGTCATGTTTGCGTCG GTGCCGGACTTTAAAGTCTTCTACACAGAGTGCGACGTCAACAAGGAAGGGCTGGAGTGC CTGCGCCTGCTCAACGAGATCATCGCCGACTTTGACGAGCTGCTGTTAAAGCCTAAGTTC AGTGGTGTGGAGAAGATCAAGACCATCGGCAGCACGTACATGGCCGCTGCGGGGCTCAGC GTCCCCTCGGGGCCTGAGAACCAGGACCTGGAGCGGCAGCACGCCCACATCGGCATCATG GTAGAGTTCAGCACCGCCCTGATGAGCAAGCTGGACGGCATCAATCGGCACTCCTTCAAC TCCTTTCGCCTCCGAGTCGGCATAAACCATGGGCCTGTGATTGCTGGAGTGATTGGGGCA CGAAAACCTCAGTACGACATCTGGGGAAACACGGTCAATGTTGCCAGTCGAATGGAGAGC ACTGGAGAACTTGGAAAAATCCAGGTTACTGAAGAGACATGTACCATCCTCCAGGGACTA GGGTATTCCTGTGAGTGCCGCGGGCTGATTGACGTCAAAGGCAAAGGTGAACTGAGGACT TACTTTGTCTGTACGGACACCGCCAAGTTCCAAGGCCTGGGGCTGAACTGA |
| Protein Properties | |
| Number of Residues | 1078 |
| Molecular Weight | 120820.0 |
| Theoretical pI | 8.1 |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>Adenylate cyclase type 7 MPAKGRYFLNEGEEGPDQDALYEKYRLTSQHGPLLLMLLLVAIAACTTLIVITFSYGDPS RHRAVLGTAFFTLAMFVLLYALVYVECLDRRGLRISALLIWGCLVTLGYVLVFDFDSPRK DTLCLWGRCPSSSFVVFVVYTLLPFSMWGAVTAGLVSSISHLLVLAMHQEDFTSPVGLKL LATAVVFVCGNLTGAFHKHHMQDASHDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAH ISMGMKLAIIERLKERGDRRYLPDNNFHNLYVKRHQNVSILYADIVGFTRLASDCSPKEL VVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPNHARNCVKMGLDMCEAIKQ VREATGVDISMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEAT LKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPQPSQHNSKNKGNATLKMRA SVRMTRYLESWGAARPFAHLNQRESVSSSETLVSHGRRPKAVPLRRHRTPDRSASPKGRS EDDSYDDEMLSAIEGLSSTRPCCSKSDDFSTFGSIFLEKGFEREYRLAPIPRVRYYFACA SLVFVCILLIHVLLLYSMKTLGVSFGLVACVLGLVLGLCFADVFLRCCPALGKLRAIAES VETQPLLRVSLAILTIGSLLVIAVVNLPLMPFRDRGLTAGNETGLRAVSGWEMSPCYLLP YYTCSCILAFIACSVFLRMSLELKVVLLTVALVAYLVLFNVYPSWQWDCCGHSLGNLTGT NGTLSSSSCSWHLKTMTNFYLVLFYTTLIMLSRQIDYYCRLDCLWKKKFKKEHEEFETME NVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGL ECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVPSGPENQDLERQHAHIG IMVEFSTALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRM ESTGELGKIQVTEETCTILQGLGYSCECRGLIDVKGKGELRTYFVCTDTAKFQGLGLN |
| External Links | |
| GenBank ID Protein | CAA89894.1 |
| UniProtKB/Swiss-Prot ID | Q29450 |
| UniProtKB/Swiss-Prot Entry Name | ADCY7_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | Z49806 |
| GeneCard ID | ADCY7 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |