| Identification |
|---|
| BMDB Protein ID
| BMDBP00466 |
| Secondary Accession Numbers
| |
| Name
| Adenylate cyclase type 7 |
| Synonyms
|
Not Available
|
| Gene Name
| ADCY7 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Signal transduction mechanisms |
| Specific Function
| Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors. Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 (By similarity). Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13) (By similarity). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex (By similarity). Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| Not Available |
| SNPs
| ADCY7 |
| Gene Sequence
|
>3291 bp
ATGCTCCCCAGGCCGTGGGGTTTCCTGCGTGGACCACTGGGTGTGCCAAGGTGGAGGATG
CCAGCCAAGGGGCGCTACTTCCTCAACGAGGGCGAGGAGGGCCCCGACCAGGATGCGCTC
TACGAGAAGTACCGCCTCACCAGCCAGCACGGGCCACTCCTGCTCATGCTCCTGTTGGTG
GCCATCGCTGCCTGCACCACGCTCATCGTCATCACCTTCAGCTATGGGGACCCCTCCAGA
CACCGGGCCGTCCTGGGGACGGCGTTCTTCACGCTCGCCATGTTTGTGCTCCTCTACGCT
CTGGTGTACGTTGAGTGCCTCGACCGGCGGGGGCTCAGGATTTCCGCGCTGCTCATCTGG
GCCTGCCTTGTGACGCTGGGCTACGTGTTGGTGTTTGATTTCGACTCGCCGAGGAAGGAC
ACCTGTGTCTTGGGGCAGGTGCCCTTCTTCCTGTTCGTGGTCTTCGTGGTGTACACGCTG
CTGCCCTTCAGCATGTGGGGCGCCGTCACGGCCGGACTCGTCTCCAGCATCTCCCACCTC
CTGGTGCTCGCAATGCACCAGGAAGACTTCACCAGCCCTGTGGGGCTGAAGCTGCTGGCC
ACTGCGGTGGTCTTCGTGTGCGGGAACCTCACAGGCGCCTTCCACAAGCACCACATGCAG
GACGCCTCCCACGACCTCTTCACCTACACAGTGAAGTGCATCCAGATTCGGCGTAAGCTG
CGCATCGAGAAGCGCCAGCAGGAGAACCTGCTGCTGTCTGTGCTGCCTGCCCACATCTCC
ATGGGCATGAAGCTGGCCATCATCGAGCGGCTCAAGGAGCGCGGGGACCGCCGTTACCTG
CCCGACAACAACTTCCACAACCTCTACGTCAAGAGGCACCAGAATGTCAGCATCCTCTAC
GCTGACATCGTGGGCTTCACGCGACTGGCCAGTGACTGCTCCCCCAAAGAGCTGGTGGTG
GTGCTGAATGAGCTCTTCGGCAAGTTTGACCAGATCGCCAAGGCCAACGAGTGCATGCGG
ATTAAGATCCTGGGCGACTGCTACTACTGCGTGTCCGGCTTGCCTGTGTCCCTGCCCAAC
CACGCCCGTAACTGTGTGAAGATGGGGCTGGACATGTGTGAGGCCATCAAGCAGGTGCGG
GAGGCCACAGGCGTGGACATCAGCATGCGCGTGGGCATCCACTCGGGGAACGTGCTGTGC
GGCGTCATCGGGCTGCGCAAGTGGCAGTACGACGTGTGGTCCCACGATGTGTCCCTGGCC
AACAGGATGGAGGCGGCCGGAGTCCCTGGCCGGGTGCACATCACAGAGGCGACGCTGAAG
CACCTGGACAAGGCGTATGAGGTGGAGGACGGGCACGGGCAGCAGCGGGACCCTTACCTC
AAAGAGATGAACATCCGCACCTACCTGGTCATCGACCCCCGGAGCCAGCAGCCGCCCCAG
CCCAGCCAGCACAACTCCAAGAACAAGGGGGACGCGACCCTGAAGATGCGGGCGTCCGTG
CGCATGACGCGCTACCTGGAGTCCTGGGGGGCGGCTCGCCCCTTCGCGCACCTCAACCAA
CGCGAGAGCGTGAGCAGCAGTGAGACCCTTGTGTCCCATGGGCGGAGGCCCAAGGCTGTT
CCCCTGAGGCGCCATCGGACCCCTGACAGAAGCGCATCCCCCAAGGGGCGGTCAGAGGAC
GACTCATACGATGATGAGATGCTGTCAGCCATCGAGGGGCTCAGCTCTACCAGACCCTGC
TGCTCCAAGTCTGATGACTTCTCCACCTTTGGGTCCATCTTCCTGGAGAAGGGCTTCGAG
CGAGAGTACCGCCTGGCGCCCATCCCCCGGGTCCGCTACTACTTCGCTTGTGCCAGCCTC
GTCTTCGTCTTCATCCTGCTCATCCACGTCTTGCTGTTGTACAGTATGAAGACTCTGGGC
GTGTCCTTTGGGCTGGTGGCCTGTGTGCTTGGGCTGGTACTAGGCTTGTGCTTCGCCGAT
GTGTTCTTGAGGTGCTGCCCGGCCCTGGGGAAGCTCCGAGCCATTGCCGAGAGCGTGGAG
ACGCAGCCCCTGCTGCGGGTGTCCCTGGCCATCCTGACCATCGGCAGCCTGCTCGTCATT
GCTGTCGTCAACCTGCCCCTGATGCCCTTCCGGGACCGGGGGCTGACTGCTGGGAACGAG
ACGGGCCTGAGGGCTGTGAGCGGCTGGGAGATGAGCCCGTGCTACCTCCTCCCGTACTAC
ACCTGCAGCTGCATCCTGGCCTTCATCGCTTGCTCTGTCTTCCTGCGGATGAGCCTGGAG
CTGAAGGTCGTGCTGCTGACCGTGGCCTTGGTGGCCTACCTGGTCCTCTTCAACGTCTAC
CCGAGCTGGCAGTGGGACTGCTGTGGCCACAGCCTGGGCAACCTCACCGGGACCAATGGC
ACCCTCAGCTCCTCATCCTGTTCATGGCATCTGAAGACGATGACCAATTTCTACCTGGTC
TTGTTCTACACCACCCTCATCATGCTCTCCAGACAGATTGACTATTATTGCCGCCTGGAC
TGTCTGTGGAAGAAGAAGTTCAAGAAGGAACACGAGGAGTTTGAAACAATGGAGAATGTG
AACCGCCTTCTTCTAGAGAATGTCCTGCCCGCGCACGTGGCCGCCCACTTCATCGGTGAC
AAGTTAAATGAGGACTGGTACCATCAGTCCTACGACTGCGTGTGTGTCATGTTTGCGTCG
GTGCCGGACTTTAAAGTCTTCTACACAGAGTGCGACGTCAACAAGGAAGGGCTGGAGTGC
CTGCGCCTGCTCAACGAGATCATCGCCGACTTTGACGAGCTGCTGTTAAAGCCTAAGTTC
AGTGGTGTGGAGAAGATCAAGACCATCGGCAGCACGTACATGGCCGCTGCGGGGCTCAGC
GTCCCCTCGGGGCCTGAGAACCAGGACCTGGAGCGGCAGCACGCCCACATCGGCATCATG
GTAGAGTTCAGCACCGCCCTGATGAGCAAGCTGGACGGCATCAATCGGCACTCCTTCAAC
TCCTTTCGCCTCCGAGTCGGCATAAACCATGGGCCTGTGATTGCTGGAGTGATTGGGGCA
CGAAAACCTCAGTACGACATCTGGGGAAACACGGTCAATGTTGCCAGTCGAATGGAGAGC
ACTGGAGAACTTGGAAAAATCCAGGTTACTGAAGAGACATGTACCATCCTCCAGGGACTA
GGGTATTCCTGTGAGTGCCGCGGGCTGATTGACGTCAAAGGCAAAGGTGAACTGAGGACT
TACTTTGTCTGTACGGACACCGCCAAGTTCCAAGGCCTGGGGCTGAACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1078 |
| Molecular Weight
| 120820.0 |
| Theoretical pI
| 8.1 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 34-54
- 63-83
- 95-120
- 125-145
- 150-170
- 176-196
- 595-615
- 620-640
- 669-688
- 718-737
- 746-773
- 792-812
|
| Protein Sequence
|
>Adenylate cyclase type 7
MPAKGRYFLNEGEEGPDQDALYEKYRLTSQHGPLLLMLLLVAIAACTTLIVITFSYGDPS
RHRAVLGTAFFTLAMFVLLYALVYVECLDRRGLRISALLIWGCLVTLGYVLVFDFDSPRK
DTLCLWGRCPSSSFVVFVVYTLLPFSMWGAVTAGLVSSISHLLVLAMHQEDFTSPVGLKL
LATAVVFVCGNLTGAFHKHHMQDASHDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAH
ISMGMKLAIIERLKERGDRRYLPDNNFHNLYVKRHQNVSILYADIVGFTRLASDCSPKEL
VVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPNHARNCVKMGLDMCEAIKQ
VREATGVDISMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEAT
LKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPQPSQHNSKNKGNATLKMRA
SVRMTRYLESWGAARPFAHLNQRESVSSSETLVSHGRRPKAVPLRRHRTPDRSASPKGRS
EDDSYDDEMLSAIEGLSSTRPCCSKSDDFSTFGSIFLEKGFEREYRLAPIPRVRYYFACA
SLVFVCILLIHVLLLYSMKTLGVSFGLVACVLGLVLGLCFADVFLRCCPALGKLRAIAES
VETQPLLRVSLAILTIGSLLVIAVVNLPLMPFRDRGLTAGNETGLRAVSGWEMSPCYLLP
YYTCSCILAFIACSVFLRMSLELKVVLLTVALVAYLVLFNVYPSWQWDCCGHSLGNLTGT
NGTLSSSSCSWHLKTMTNFYLVLFYTTLIMLSRQIDYYCRLDCLWKKKFKKEHEEFETME
NVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGL
ECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVPSGPENQDLERQHAHIG
IMVEFSTALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRM
ESTGELGKIQVTEETCTILQGLGYSCECRGLIDVKGKGELRTYFVCTDTAKFQGLGLN
|
| External Links |
|---|
| GenBank ID Protein
| CAA89894.1 |
| UniProtKB/Swiss-Prot ID
| Q29450 |
| UniProtKB/Swiss-Prot Entry Name
| ADCY7_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Z49806 |
| GeneCard ID
| ADCY7 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
