Showing Protein Protein phosphatase 1B (BMDBP00468)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00468 |
| Secondary Accession Numbers | None |
| Name | Protein phosphatase 1B |
| Synonyms | Not Available |
| Gene Name | PPM1B |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Signal transduction mechanisms |
| Specific Function | Enzyme with a broad specificity. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 11 |
| Locus | Not Available |
| SNPs | PPM1B |
| Gene Sequence |
>1164 bp ATGGGTGCATTTTTGGACAAACCCAAAACTGAGAAACATAATGCTCATGGTGCTGGGAAT GGTTTACGTTACGGCCTGAGCAGCATGCAAGGATGGAGAGTGGAAATGGAAGATGCGCAC ACAGCTGTTGTAGGTATTCCGCACGGCTTGGAAGACTGGTCGTTTTTTGCAGTTTATGAT GGTCACGCCGGATCCCGAGTAGCAAATTACTGCTCAACACACTTATTAGAACACATCACG AACAACGAAGACTTCAGGGCAGCTGGAAAGTCAGGATCTGCTCTTGAGCCTTCAGTGGAA AATGTCAAGAATGGTATCAGAACTGGCTTTTTGAAGATTGATGAATACATGCGTAACTTT TCAGACCTCAGAAATGGCATGGACAGGAGCGGTTCAACTGCAGTGGGAGTTATGATTTCA CCTAAGCACATCTACTTCATCAACTGTGGCGATTCACGGGCTGTTCTGTATAGGAGTGGA CAAGTCTGCTTTTCTACCCAAGATCACAAACCTTGCAACCCAAGGGAGAAAGAGCGAATC CAAAATGCAGGAGGCAGCGTAATGATACAGCGTGTTAATGGTTCATTAGCAGTGTCTCGT GCTCTGGGGGACTATGATTACAAGTGTGTTGATGGCAAGGGCCCAACAGAACAACTTGTT TCTCCAGAGCCTGAGGTTTATGAAATTTTAAGAGCAGAAGAGGATGAATTTATCATCTTG GCTTGTGATGGGATCTGGGATGTTATGAGTAATGAGGAGCTCTGTGAATTTGTTAAATCT AGGCTTGAGGTATCTGATGACCTGGAAAATGTGTGCAATTGGGTAGTGGACACTTGTTTA CATAAGGGAAGTCGAGATAACATGAGTATTGTACTAGTTTGCTTTTCAAATGCTCCCAAG GTCTCAGATGAAGCAATGAGAAAAGACTCAGAGTTGGATAAGTACTTGGAATCACGGGTG GAAGAAATTATGGAGAAGTCTGGTGAGGAAGGGATGCCTGATCTTGCCCACGTCATGCGC ATCTTGTCTGCAGAAAATATCCCAAATTTGCCTCCTGGGGGAGGTCTTGCTGGCAAGCGC CATGTTATTGAAGCTGTTTATAGTAGGCTGAATCCACATAGAGAAAGTGATGGGGGTGCT GGAGATCTAGAAGACCCATGGTAG |
| Protein Properties | |
| Number of Residues | 484 |
| Molecular Weight | 53431.0 |
| Theoretical pI | 4.73 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Protein phosphatase 1B MGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYD GHAGSRVANYCSTHLLEHITNNEDFRAAGKSGSALEPSVENVKNGIRTGFLKIDEYMRNF SDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRSGQVCFSTQDHKPCNPREKERI QNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIIL ACDGIWDVMSNEELCEFVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPK VSDEAMRKDSELDKYLESRVEEIMEKSGEEGMPDLAHVMRILSAENIPNLPPGGGLAGNI IFFRRHVIEAVYSRLNPHRESDGASDEAEESGSQGKLVEALRQMRINHRGNYRQLLEEML TSYRLAKVEGEENPAEQAATAASSNSDAGNTVAMQESHTESKSDLAELDSCTEDAGTKMS GEKL |
| External Links | |
| GenBank ID Protein | CAA06555.1 |
| UniProtKB/Swiss-Prot ID | O62830 |
| UniProtKB/Swiss-Prot Entry Name | PPM1B_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | AJ005458 |
| GeneCard ID | PPM1B |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |