Showing Protein Integrin-linked kinase-associated serine/threonine phosphatase 2C (BMDBP00470)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00470 |
| Secondary Accession Numbers | None |
| Name | Integrin-linked kinase-associated serine/threonine phosphatase 2C |
| Synonyms | Not Available |
| Gene Name | ILKAP |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Signal transduction mechanisms |
| Specific Function | Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 3 |
| Locus | Not Available |
| SNPs | ILKAP |
| Gene Sequence |
>1113 bp ATGGACCTGTTCGGGGACCTGCCGGAGCCCGAGCGCTCGCCGCGGCCGGCTGCTGGCTCT GGGGGACCTTTGCTTTTTGACGATCTCCCGCCAGCCAGCAGTGGCGATTCAGGTTCTCTT GACACTTCGTTATCCGAGGAGGTAAAGAATGAAGGGAAAGGAGCAAAGAGAAAAGCCTCT GATGAAGAGAAGAATGGGAGTGAAGAGCTTGTGGAAAAGAAAGTTTGTAAAGCCTCTTCG GTGATCTTCAGCCTGAAAGGCTACGTGGCTGAGCGGAAGGGCGAGCGGGAAGAGATGCAG GATGCCCACGTCATCCTGAACGACATCACCGCGGAGTGCCAGCCCCCGTCCGCTCTCGTC ACCCGGGTTTCATACTTTGCTGTTTTTGATGGACATGGAGGAATTCGAGCCTCAAAATTC GCCGCACAGAATTTGCATCAGAACTTAATCAGGAAATTTCCTAAAGGAGATGGAATCAGC GTAGAGAAAACGGTGAAAAGGTGCCTTCTGGACACCTTCAAGCATACTGATGAAGAGTTC CTTAAGCAAGCCTCAAGCCAGAAACCTGCCTGGAAAGATGGGTCCACTGCCACGTGTGTG CTGGCCGTAGACAACACTCTTTACATCGCCAACCTGGGGGACAGTCGGGCAATCCTTTGT CGTTACAATGAGGAGAGTCAAAAACACGCGGCCTTAAGCCTCAGCAAGGAGCATAATCCA ACCCAGTATGAAGAACGAATGAGAATACAGAAGGCCGGAGGGAATGTCAGGGACGGGCGT GTCCTGGGTGTGCTGGAGGTGTCCCGCTCCATCGGGGACGGGCAGTACAAGCGCTGCGGG GTCACCTCGGTGCCGGACATCAGACGCTGCCAGCTGACCCCCAACGACAGGTTTATTTTG CTGGCCTGTGATGGCCTCTTCAAGGTCTTTACCCCAGAAGAAGCCGTGAACTTCATCTTG TCCTGCCTGGAGGACGAGAAGATCCAAAGGCGGGAAGGGAAGCCCACTGTGGATGCCCGC TACGAAGCCGCCTGCAACAGGCTGGCCAACAAGGCGGTGCAGCGGGGCTCGGCGGACAAC GTCACCGTGATGGTGGTGCGGATAGGGCTCTGA |
| Protein Properties | |
| Number of Residues | 370 |
| Molecular Weight | 40622.0 |
| Theoretical pI | 7.05 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Integrin-linked kinase-associated serine/threonine phosphatase 2C MDLFGDLPEPERSPRPAAGSGGPLLFDDLPPASSGDSGSLDTSLSEEVKNEGKGAKRKAS DEEKNGSEELVEKKVCKASSVIFSLKGYVAERKGEREEMQDAHVILNDITAECQPPSALV TRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDGISVEKTVKRCLLDTFKHTDEEF LKQASSQKPAWKDGSTATCVLAVDNTLYIANLGDSRAILCRYNEESQKHAALSLSKEHNP TQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKRCGVTSVPDIRRCQLTPNDRFIL LACDGLFKVFTPEEAVNFILSCLEDEKIQRREGKPTVDARYEAACNRLANKAVQRGSADN VTVMVVRIGL |
| External Links | |
| GenBank ID Protein | AAI22678.1 |
| UniProtKB/Swiss-Prot ID | Q0IIF0 |
| UniProtKB/Swiss-Prot Entry Name | ILKAP_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC122677 |
| GeneCard ID | ILKAP |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |