| Identification |
|---|
| BMDB Protein ID
| BMDBP00471 |
| Secondary Accession Numbers
| |
| Name
| Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| IDH3B |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 13 |
| Locus
| Not Available |
| SNPs
| IDH3B |
| Gene Sequence
|
>1152 bp
ATGGCTGCCCTCAGCCGTGTCCGCTGGCTGACCCGAGCACTGGTCGCCGCTCCGAATCCC
GGAGCATGGAGGAGCCTGTGTACCTCAACCGTGGCGCAAGCCTCCTCGCGGACCCAGGGC
GAGGATGTGAGGGTGGAGGGCGCCTTTCCCGTGACTATGCTGCCAGGAGACGGCGTGGGG
CCTGAGCTGATGCACGCTGTCAAGGAGGTGTTCAAGGCTGCCTCTGTCCCAGTGGAGTTC
CAGGAGCATCACCTGAGCGAGGTGCAGAATATGGCATCTGAGGAGAAGCTGGAGCAGGTG
CTGAGTTCCATGAAGGAGAACAAAGTGGCCATCATTGGAAAGATCCACACCCCAATGGAG
TATAAAGGGGAGCTAGCCTCCTATGATATGCGGCTGAGGCGGAAGTTGGACTTGTTTGCC
AATGTGGTCCATGTGAAGTCACTTCCTGGGTACAAGACTCGACACAACAATCTAGATTTG
GTGATTATTCGAGAGCAGACAGAAGGGGAGTACAGTTCTCTGGAACACGAGAGTGCGAGG
GGTGTGATTGAGTGCTTGAAGATTGTCACTCGAACCAAATCACAGCGGATTGCAAAGTTC
GCCTTTGACTATGCCACTAAGAAGGGGCGGGGCAAGGTCACGGCTGTCCACAAGGCCAAT
ATCATGAAACTGGGGGATGGGTTGTTCCTGCAGTGCTGTGAGGAAGTTGCTGAACTGTAT
CCCAAGATCAAGTTTGAGAAAATGATCATAGACAACTGCTGCATGCAGCTGGTGCAGAAT
CCTTACCAGTTTGACGTGCTGGTGATGCCCAATCTCTATGGGAACATTATTGACAATCTG
GCTGCTGGCCTGGTTGGGGGAGCTGGTGTGGTCCCTGGTGAGAGCTACAGTGCAGAGTAC
GCAGTGTTTGAGACGGGTGCCCGGCATCCATTTGCCCAGGCAGTGGGCAGGAATATAGCC
AACCCCACAGCCATGCTGCTGTCAGCTTCCAACATGCTGCGGCATCTCAATCTCGAGCAT
CACTCCAACATGATTGCAGAGGCAGTGAAGAAGGTGATTAAAGTTGGCAAGGTTCGAACT
TCTGACATGGGTGGTTATGCCACCTGCCAAGACTTCACTGAGGCTGTCATTGGTGCCCTG
TCCAACCCATAG
|
| Protein Properties |
|---|
| Number of Residues
| 385 |
| Molecular Weight
| 42497.0 |
| Theoretical pI
| 8.91 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
MAALSRVRWLTRALVAAPNPGAWRSLCTSTVAQASSRTQGEDVRVEGAFPVTMLPGDGVG
PELMHAVKEVFKAASVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAIIGKIHTPME
YKGELASYDMRLRRKLDLFANVVHVKSLPGYKTRHNNLDLVIIREQTEGEYSSLEHESAR
GVIECLKIVTRTKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELY
PKIKFEKMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEY
AVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEHHSNMIAEAVKKVIKVGKVRT
RDMGGYSTTTDFIKSVIGHLHPYGG
|
| External Links |
|---|
| GenBank ID Protein
| AAC83166.1 |
| UniProtKB/Swiss-Prot ID
| O77784 |
| UniProtKB/Swiss-Prot Entry Name
| IDH3B_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF090321 |
| GeneCard ID
| IDH3B |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
