| Identification |
|---|
| BMDB Protein ID
| BMDBP00473 |
| Secondary Accession Numbers
| None |
| Name
| Serine/threonine-protein kinase 4 |
| Synonyms
|
Not Available
|
| Gene Name
| STK4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 13 |
| Locus
| Not Available |
| SNPs
| STK4 |
| Gene Sequence
|
>1464 bp
ATGGAGACGGTGCAGCTTAGGAACCCGCCGCGCCGGCAGCTGAAAAAGTTGGATGAAGAT
AGTTTAACTAAACAACCGGAAGAAGTGTTTGATGTCTTAGAGAAACTTGGAGAAGGGTCC
TATGGCAGCGTGTACAAAGCTATTCATAAAGAGACCGGTCAGATTGTTGCTATTAAGCAA
GTTCCTGTGGAATCAGACCTGCAGGAGATAATCAAAGAAATCTCTATCATGCAGCAATGT
GACAGCCCTCATGTAGTCAAATATTACGGCAGTTACTTTAAGAACACAGACTTGTGGATC
GTGATGGAGTACTGTGGGGCTGGTTCTGTATCTGATATTATTCGATTACGAAATAAAACG
TTAACAGAAGATGAAATAGCTACAATATTACAGTCAACACTTAAGGGACTGGAATATCTT
CATTTTATGAGAAAAATACACCGAGATATCAAAGCAGGAAATATTTTGCTCAATACAGAA
GGTCATGCAAAACTTGCAGATTTTGGGGTAGCAGGTCAACTTACAGATACCATGGCCAAG
CGAAATACAGTGATAGGAACACCTTTTTGGATGGCTCCAGAAGTGATCCAGGAAATTGGG
TACAACTGTGTAGCAGACATCTGGTCATTGGGAATAACAGCCATAGAAATGGCTGAAGGA
AAGCCTCCATATGCTGATATCCATCCAATGAGGGCCATCTTCATGATTCCTACCAACCCA
CCCCCCACATTCCGAAAGCCGGAACTGTGGTCAGATAGCTTCATGGATTTTGTGAAGCAG
TGTCTTGTCAAGAGCCCCGAGCAGAGAGCCACAGCCACTCAACTCCTCCAGCACCCGTTT
GTCAAGAGTGCCAAAGGAGTGTCCATACTGCGGGACTTGATTAATGAAGCCATGGACGTG
AAGCTGAAACGCCAGGAGGCCCAGCAGCGGGAGGTGGACCAGGAGGAGGAAGAAAACTCT
GAGGAGGATGAGCTAGATTCTGGCACGATGGTCCGAGCAGCAGGGGATGAGATGGGCACT
GTCCGAGTAGCCAGCAGCATGAGTGACGGGGCCAATACGATGATCGAGCACGATGACACG
TTGCCGTCCCAGCTGGGCACCATGGTGATCAACACGGAGGACGAGGAAGAAGAAGGCACA
ATGAAAAGAAGGGACGAGACCATGCAGCCTGCCAGACCATCGTTCCTTGAATATTTCGAA
CAAAAAGAAAAGGAAAATCAGATCAACAGCTTCGGCAAGAGTGTCCCTGGCCCATTGCAG
AACTCCTCAGATTGGAAAGTTCCCCAGGATGGAGACTATGAATTCCTGAAGAGTTGGACG
GTGGAAGACCTTCAGAAGAGGCTCCTGGCCCTGGACCCCATGATGGAGCAGGAGATTGAG
GAGATCCGGCAGAAGTACCAGTCGAAGCGGCAGCCCATCCTGGACGCCATTGAGGCCAAG
AAGCGGCGGCAGCAGAACTTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 487 |
| Molecular Weight
| 55587.0 |
| Theoretical pI
| 4.68 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Serine/threonine-protein kinase 4
METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQ
VPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT
LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK
RNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNP
PPTFRKPELWSDSFMDFVKQCLVKSPEQRATATQLLQHPFVKSAKGVSILRDLINEAMDV
KLKRQEAQQREVDQEEEENSEEDELDSGTMVRAAGDEMGTVRVASSMSDGANTMIEHDDT
LPSQLGTMVINTEDEEEEGTMKRRDETMQPARPSFLEYFEQKEKENQINSFGKSVPGPLQ
NSSDWKVPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAK
KRRQQNF
|
| External Links |
|---|
| GenBank ID Protein
| AAX08921.1 |
| UniProtKB/Swiss-Prot ID
| Q5E9L6 |
| UniProtKB/Swiss-Prot Entry Name
| STK4_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT020904 |
| GeneCard ID
| STK4 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
