Showing Protein ATP-dependent 6-phosphofructokinase, liver type (BMDBP00479)
| Identification | |||
|---|---|---|---|
| BMDB Protein ID | BMDBP00479 | ||
| Secondary Accession Numbers | None | ||
| Name | ATP-dependent 6-phosphofructokinase, liver type | ||
| Synonyms | Not Available | ||
| Gene Name | PFKL | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Carbohydrate transport and metabolism | ||
| Specific Function | Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (By similarity). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity). | ||
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| Reactions |
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 1 | ||
| Locus | Not Available | ||
| SNPs | PFKL | ||
| Gene Sequence |
>2343 bp ATGGCCAGCGTGGATCTGGAGAAGCTGCGGACCACCGGGGCTGGCAAGGCCATCGGCGTG CTGACCAGTGGCGGTGATGCGCAAGGCATGAATGCCGCTGTCAGAGCCGTGACTCGTATG GGCATTTACGTGGGGGCCAAGGTCTTCCTCATCTACGAGGGCTATGAAGGCCTCGTGGAG GGCGGCGAGAACATCAAGCAGGCCAACTGGCTGAGCGTCTCCAACATCATCCAGTTGGGC GGCACCGTCATCGGCAGCGCCCGCTGCAAGGCCTTCACCACGCGGGAGGGACGCCGGGCG GCCGCCTACAACCTGGTCCAGCGTGGCATCACCAACCTGTGCGTCATCGGCGGGGACGGC AGCCTCACTGGGGCCAACATCTTCCGCAGCGAGTGGGGCAGCCTCCTGGAGGAGCTGGTG AGCGAAGGCAAGATCTCAGAGGGCACGGCTCAGACCTATTCACACCTGAACATCGCGGGG CTGGTGGGCTCCATCGACAATGACTTCTGTGGCACCGACATGACCATCGGCACAGACTCG GCGCTGCACCGCATCATGGAAGTCATCGACGCCATCACCACCACTGCCCAGAGCCACCAG AGGACCTTTGTGCTGGAGGTGATGGGACGGCACTGCGGGTACCTGGCCCTGGTGTCTGCC CTGGCCTCGGGGGCCGACTGGCTGTTCATCCCTGAGGCGCCCCCTGAGGACGGCTGGGAG AACTTCATGTGTGAGCGGCTCGGCGAGACTCGGAGCCGAGGGTCCCGCCTCAACATTATC ATCATTGCTGAGGGCGCCATCGACCGCAACGGGAAGCCCATCTCGTCCCGCTACGTGAAG GACCTGGTGGTCCAGAGACTGGGCTTCGACACGCGTGTGACTGTGCTGGGCCACGTGCAG AGGGGAGGGACCCCCTCGGCATTCGACCGCATCCTGAGCAGTAAGATGGGCATGGAGGCG GTGATGGCGCTGCTGGAGGCCACGCCCGACACGCCGGCCTGCGTGGTCAGCCTCTCGGGG AACCAGTCCGTGCGGCTGCCCCTCATGGAGTGTGTGCAGATGACCAAGGAGGTGCAGAAG GCCATGGACGAGAAGAGGTTTGACGAGGCCATCCAGCTCCGAGGCGGGAGCTTTGAGAAC AACTGGAATATTTACAAGCTGCTTTCCCACCAGAAGATCTCCAAGGAGAAGACCAACTTC TCCCTGGCCATCCTGAACGTGGGGGCCCCAGCAGCCGGCATGAACGCGGCCGTGCGCTCG GCGGTGCGTTCTGGCATCTCCCAGGGCCACACGGTGTACGTTGTGCATGACGGCTTTGAA GGCCTGGCCAAGAACCAGGTGCAAGAAGTGAGCTGGCATGACGTGGCCGGCTGGCTGGGG CGTGGTGGCTCCATGCTGGGGACAAAGAGGACGCTGCCCAAAGGCTTCATGGAGAAAATT GTGGAAAACATCCGCCTTCACAACATCCACGCCCTGCTGGTCATCGGGGGCTTTGAGGCC TACGAGGGGGTGCTGCAGCTGGTGGAGGCCCGTGGGCGCTATGAGGAGCTGTGCATCGTC ATGTGCGTCATCCCCGCCACCATCAGCAACAACGTGCCAGGCACGGACTTCAGCCTGGGC TCCGACACGGCCGTCAACGCCGCCATGGAGAGTTGTGACCGCATCAAGCAGTCGGCCTCG GGGACCAAGCGCCGTGTGTTCATCGTGGAGACCATGGGTGGCTACTGCGGCTACCTGGCT ACTGTGACTGGCATTGCTGTGGGCGCCGACGCTGCCTATGTCTTCGAGGATCCCTTCAAC ATTCAAGACTTAAAGGCCAATGTGGAGCACATGACCGAGAAGATGAAGACAGAGATCCAG CGGGGCCTGGTACTCCGGAACGAGAAGTGCCACGAGCACTACACCACAGAGTTCCTGTAC AACCTCTACTCCTCCGAGGGCAAGGGCGTGTTTGACTGCAGGACCAACGTCCTGGGCCAC CTGCAGCAGGGTGGAGCTCCCACCCCCTTTGACCGGAACTATGGTACCAAGCTCGGGGTG AAAGCCATAATCTGGATGTCGGAGAAGCTGCGGGCAGTCTATCGCAATGGGCGGGTGTTT GCCAATGCCTCTGACTCGGCCTGCGTGATTGGCCTGCAGAAGAAAGTGGTGGCCTTCAGC CCTGTCACCGAGCTCAAGAAAGACACCGACTTTGAGCACCGCATGCCCCGGGAGCAGTGG TGGCTGAACCTGCGGCTCATGCTGAAGATGCTGGCACACTACCGCATCAGCATGGCTGAC TACGTGTCCGGGGAGCTGGAGCACGTCACCCGCCGCACCCTCAGCATTGAGACGGGCTTC TGA |
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| Protein Properties | |||
| Number of Residues | 780 | ||
| Molecular Weight | 85292.0 | ||
| Theoretical pI | 7.39 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions | Not Available | ||
| Protein Sequence |
>6-phosphofructokinase, liver type MASVDLEKLRTTGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVE GGENIKQANWLSVSNIIQLGGTVIGSARCKAFTTREGRRAAAYNLVQRGITNLCVIGGDG SLTGANIFRSEWGSLLEELVSEGKISEGTAQTYSHLNIAGLVGSIDNDFCGTDMTIGTDS ALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWE NFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSRYVKDLVVQRLGFDTRVTVLGHVQ RGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVSLSGNQSVRLPLMECVQMTKEVQK AMDEKRFDEAIQLRGGSFENNWNIYKLLSHQKISKEKTNFSLAILNVGAPAAGMNAAVRS AVRSGISQGHTVYVVHDGFEGLAKNQVQEVSWHDVAGWLGRGGSMLGTKRTLPKGFMEKI VENIRLHNIHALLVIGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLG SDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFN IQDLKANVEHMTEKMKTEIQRGLVLRNEKCHEHYTTEFLYNLYSSEGKGVFDCRTNVLGH LQQGGAPTPFDRNYGTKLGVKAIIWMSEKLRAVYRNGRVFANASDSACVIGLQKKVVAFS PVTELKKDTDFEHRMPREQWWLNLRLMLKMLAHYRISMADYVSGELEHVTRRTLSIETGF |
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| External Links | |||
| GenBank ID Protein | AAI26579.1 | ||
| UniProtKB/Swiss-Prot ID | A1A4J1 | ||
| UniProtKB/Swiss-Prot Entry Name | PFKAL_BOVIN | ||
| PDB IDs | Not Available | ||
| GenBank Gene ID | BC126578 | ||
| GeneCard ID | PFKL | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||