| Identification |
|---|
| BMDB Protein ID
| BMDBP00479 |
| Secondary Accession Numbers
| None |
| Name
| ATP-dependent 6-phosphofructokinase, liver type |
| Synonyms
|
Not Available
|
| Gene Name
| PFKL |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Carbohydrate transport and metabolism |
| Specific Function
| Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (By similarity). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity). |
| Pathways
|
- Carbohydrate degradation
- D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4
- Fructose and Mannose Degradation
- Glycolysis
- LPS and Citrate Signaling and Inflammation
- Pentose Phosphate Pathway
- Warburg Effect
|
| Reactions
|
| Fructose 6-phosphate + Adenosine triphosphate → Fructose 1,6-bisphosphate + ADP |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| Not Available |
| SNPs
| PFKL |
| Gene Sequence
|
>2343 bp
ATGGCCAGCGTGGATCTGGAGAAGCTGCGGACCACCGGGGCTGGCAAGGCCATCGGCGTG
CTGACCAGTGGCGGTGATGCGCAAGGCATGAATGCCGCTGTCAGAGCCGTGACTCGTATG
GGCATTTACGTGGGGGCCAAGGTCTTCCTCATCTACGAGGGCTATGAAGGCCTCGTGGAG
GGCGGCGAGAACATCAAGCAGGCCAACTGGCTGAGCGTCTCCAACATCATCCAGTTGGGC
GGCACCGTCATCGGCAGCGCCCGCTGCAAGGCCTTCACCACGCGGGAGGGACGCCGGGCG
GCCGCCTACAACCTGGTCCAGCGTGGCATCACCAACCTGTGCGTCATCGGCGGGGACGGC
AGCCTCACTGGGGCCAACATCTTCCGCAGCGAGTGGGGCAGCCTCCTGGAGGAGCTGGTG
AGCGAAGGCAAGATCTCAGAGGGCACGGCTCAGACCTATTCACACCTGAACATCGCGGGG
CTGGTGGGCTCCATCGACAATGACTTCTGTGGCACCGACATGACCATCGGCACAGACTCG
GCGCTGCACCGCATCATGGAAGTCATCGACGCCATCACCACCACTGCCCAGAGCCACCAG
AGGACCTTTGTGCTGGAGGTGATGGGACGGCACTGCGGGTACCTGGCCCTGGTGTCTGCC
CTGGCCTCGGGGGCCGACTGGCTGTTCATCCCTGAGGCGCCCCCTGAGGACGGCTGGGAG
AACTTCATGTGTGAGCGGCTCGGCGAGACTCGGAGCCGAGGGTCCCGCCTCAACATTATC
ATCATTGCTGAGGGCGCCATCGACCGCAACGGGAAGCCCATCTCGTCCCGCTACGTGAAG
GACCTGGTGGTCCAGAGACTGGGCTTCGACACGCGTGTGACTGTGCTGGGCCACGTGCAG
AGGGGAGGGACCCCCTCGGCATTCGACCGCATCCTGAGCAGTAAGATGGGCATGGAGGCG
GTGATGGCGCTGCTGGAGGCCACGCCCGACACGCCGGCCTGCGTGGTCAGCCTCTCGGGG
AACCAGTCCGTGCGGCTGCCCCTCATGGAGTGTGTGCAGATGACCAAGGAGGTGCAGAAG
GCCATGGACGAGAAGAGGTTTGACGAGGCCATCCAGCTCCGAGGCGGGAGCTTTGAGAAC
AACTGGAATATTTACAAGCTGCTTTCCCACCAGAAGATCTCCAAGGAGAAGACCAACTTC
TCCCTGGCCATCCTGAACGTGGGGGCCCCAGCAGCCGGCATGAACGCGGCCGTGCGCTCG
GCGGTGCGTTCTGGCATCTCCCAGGGCCACACGGTGTACGTTGTGCATGACGGCTTTGAA
GGCCTGGCCAAGAACCAGGTGCAAGAAGTGAGCTGGCATGACGTGGCCGGCTGGCTGGGG
CGTGGTGGCTCCATGCTGGGGACAAAGAGGACGCTGCCCAAAGGCTTCATGGAGAAAATT
GTGGAAAACATCCGCCTTCACAACATCCACGCCCTGCTGGTCATCGGGGGCTTTGAGGCC
TACGAGGGGGTGCTGCAGCTGGTGGAGGCCCGTGGGCGCTATGAGGAGCTGTGCATCGTC
ATGTGCGTCATCCCCGCCACCATCAGCAACAACGTGCCAGGCACGGACTTCAGCCTGGGC
TCCGACACGGCCGTCAACGCCGCCATGGAGAGTTGTGACCGCATCAAGCAGTCGGCCTCG
GGGACCAAGCGCCGTGTGTTCATCGTGGAGACCATGGGTGGCTACTGCGGCTACCTGGCT
ACTGTGACTGGCATTGCTGTGGGCGCCGACGCTGCCTATGTCTTCGAGGATCCCTTCAAC
ATTCAAGACTTAAAGGCCAATGTGGAGCACATGACCGAGAAGATGAAGACAGAGATCCAG
CGGGGCCTGGTACTCCGGAACGAGAAGTGCCACGAGCACTACACCACAGAGTTCCTGTAC
AACCTCTACTCCTCCGAGGGCAAGGGCGTGTTTGACTGCAGGACCAACGTCCTGGGCCAC
CTGCAGCAGGGTGGAGCTCCCACCCCCTTTGACCGGAACTATGGTACCAAGCTCGGGGTG
AAAGCCATAATCTGGATGTCGGAGAAGCTGCGGGCAGTCTATCGCAATGGGCGGGTGTTT
GCCAATGCCTCTGACTCGGCCTGCGTGATTGGCCTGCAGAAGAAAGTGGTGGCCTTCAGC
CCTGTCACCGAGCTCAAGAAAGACACCGACTTTGAGCACCGCATGCCCCGGGAGCAGTGG
TGGCTGAACCTGCGGCTCATGCTGAAGATGCTGGCACACTACCGCATCAGCATGGCTGAC
TACGTGTCCGGGGAGCTGGAGCACGTCACCCGCCGCACCCTCAGCATTGAGACGGGCTTC
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 780 |
| Molecular Weight
| 85292.0 |
| Theoretical pI
| 7.39 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>6-phosphofructokinase, liver type
MASVDLEKLRTTGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVE
GGENIKQANWLSVSNIIQLGGTVIGSARCKAFTTREGRRAAAYNLVQRGITNLCVIGGDG
SLTGANIFRSEWGSLLEELVSEGKISEGTAQTYSHLNIAGLVGSIDNDFCGTDMTIGTDS
ALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWE
NFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSRYVKDLVVQRLGFDTRVTVLGHVQ
RGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVSLSGNQSVRLPLMECVQMTKEVQK
AMDEKRFDEAIQLRGGSFENNWNIYKLLSHQKISKEKTNFSLAILNVGAPAAGMNAAVRS
AVRSGISQGHTVYVVHDGFEGLAKNQVQEVSWHDVAGWLGRGGSMLGTKRTLPKGFMEKI
VENIRLHNIHALLVIGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLG
SDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFN
IQDLKANVEHMTEKMKTEIQRGLVLRNEKCHEHYTTEFLYNLYSSEGKGVFDCRTNVLGH
LQQGGAPTPFDRNYGTKLGVKAIIWMSEKLRAVYRNGRVFANASDSACVIGLQKKVVAFS
PVTELKKDTDFEHRMPREQWWLNLRLMLKMLAHYRISMADYVSGELEHVTRRTLSIETGF
|
| External Links |
|---|
| GenBank ID Protein
| AAI26579.1 |
| UniProtKB/Swiss-Prot ID
| A1A4J1 |
| UniProtKB/Swiss-Prot Entry Name
| PFKAL_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC126578 |
| GeneCard ID
| PFKL |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
