Showing Protein Endoribonuclease Dicer (BMDBP00484)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00484 |
| Secondary Accession Numbers | None |
| Name | Endoribonuclease Dicer |
| Synonyms | Not Available |
| Gene Name | DICER1 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Replication, recombination and repair |
| Specific Function | Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 21 |
| Locus | Not Available |
| SNPs | DICER1 |
| Gene Sequence |
>5772 bp ATGAAAAGCCCTGCTTTGCAACCCCTCAGCATGGCAGGCCTGCAGCTCATGACCCCTGCT TCCTCACCAATGGGTCCTTTCTTTGGACTGCCATGGCAACAAGAAGCAATTCATGATAAC ATTTATACGCCAAGAAAATATCAGGTTGAACTGCTTGAAGCAGCTCTGGATCATAATACC ATAGTCTGTTTAAACACTGGCTCAGGGAAGACGTTTATTGCAGTACTACTCACTAAAGAG CTGTCTTATCAGATCAGGGGAGACTTCAACAGAAATGGCAAAAGGACGGTGTTCTTGGTC AACTCTGCAAACCAGGTTGCCCAACAAGTGTCAGCTGTCAGAACTCACTCAGATCTCAAG GTCGGGGAATACTCAAACCTAGAAGTAAGTGCATCTTGGACAAAAGAGAAATGGAACCAA GAGTTTACTAAGCACCAGGTTCTCATTATGACCTGCTATGTCGCCTTGAATGTTTTGAAA AATGGTTACTTATCACTGTCAGACATTAACCTTTTGGTGTTTGATGAGTGTCATCTTGCA ATCCTAGACCACCCCTACCGAGAAATTATGAAGCTTTGTGAAAATTGTCCATCATGTCCT CGTATTTTGGGACTAACTGCTTCCATTTTAAATGGGAAATGTGATCCAGAGGAATTGGAA GAGAAGATTCAGAAACTGGAGAAAATTCTTAAGAGTAATGCTGAAACTGCAACTGACTTG GTGGTCTTAGACAGATATACTTCTCAGCCATGTGAGATTGTGGTAGACTGTGGACCATTT ACTGACAGAAGTGGGCTTTATGAAAGACTGCTGATGGAGTTAGAAGAAGCACTTAATTTT ATCAATGACTGTAACATATCTGTACATTCAAAAGAAAGAGATTCTACTTTAATTTCTAAA CAGATACTCTCAGACTGCCGTGCGGTCCTGGTTGTCCTGGGACCCTGGTGTGCCGATAAA GTAGCTGGAATGATGGTCAGAGAGCTGCAGAAACACATCAAACATGAGCAGGAGGAGCTG CACCGGAAGTTTCTGTTGTTCACAGACACTTTCCTACGGAAAATCCACGCCCTGTGTGAA GAGCACTTCTCCCCTGCCTCGCTTGACCTGAAGTTTGTCACTCCTAAAGTAATAAAGCTG CTCGAGATCTTACGCAAATACAAACCGTATGAGCGGCAGCAGTTTGAAAGCGTGGAGTGG TATAATAATAGGAACCAGGATAATTACGTGTCCTGGAGCGATTCTGAGGATGACGAGGAA GATGAAGAGATTGAAGAGAAAGAAAAGCCAGAGACAAATTTTCCTTCTCCGTTTACCAAC ATTTTGTGTGGAATTATTTTTGTGGAAAGAAGATACACAGCCGTGGTCTTAAACAGATTG ATAAAGGAAGCTGGCAAACAAGATCCAGAGCTGGCTTACATCAGCAGCAATTTTATAACT GGACATGGCATCGGAAAGAATCAGCCTCGGAACAAACAGATGGAAGCGGAATTCAGAAAA CAGGAAGAGGTACTTAGGAAATTTCGAGCACATGAAACCAACCTGCTTATTGCAACAAGT ATTGTGGAGGAGGGTGTTGACATACCGAAATGCAACTTGGTGGTTCGTTTCGATCTGCCC ACAGAGTATCGATCCTACGTTCAGTCCAAGGGAAGAGCGAGGGCACCCATCTCTAATTAT GTAATGTTAGCAGACACAGATAAAATAAAGAGTTTTGAAGAAGACCTTAAAACATACAAA GCTATTGAAAAGATCTTGCGAAACAAATGTTCCAAGTCGGTTGATACCGGGGAGGCCGAC ACGGAGCCCGTGGTGGATGACGACGATGTTTTCCCACCGTATGTGCTGAGGCCTGAGGAC GGTCCCCGCGTCACGATCAACACGGCCATTGGGCACGTCAACAGATACTGTGCTAGATTA CCAAGTGATCCGTTTACTCATCTGGCTCCTAAATGTAGAACCCGAGAGTTGCCTGATGGT ACATTTTATTCAACTCTTTATCTGCCAATTAACTCACCTCTTCGAGCCTCCATTGTTGGT CCCCCAATGAGCTGCATTCGGTTGGCTGAAAGAGTCGTGGCTCTCATTTGCTGTGAAAAA CTGCACAAAATTGGCGAACTGGATGACCATTTGATGCCAGTTGGGAAGGAGACTGTTAAA TATGAGGAAGAGCTGGATTTACACGATGAAGAAGAGACCAGTGTTCCAGGAAGACCAGGT TCCACAAAACGAAGACAGTGCTACCCAAAAGCAATTCCAGAATGTTTGAGGGAGAGCTAC CCCAGGCCTGGTCAGCCCTGTTACCTGTACGTGATCGGAATGGTCCTGACGACACCTTTA CCTGATGAGCTCAACTTCAGAAGGCGGAAGCTCTACCCCCCTGAGGACACCACAAGATGC TTTGGAATACTGACAGCCAAGCCCATACCTCAGATCCCACACTTTCCTGTGTACACGCGC TCTGGAGAGGTGACCATATCTATTGAGTTGAAGAAGTCCGGCTTCACGTTATCTCTGCAA ATGCTTGAGTTGATCACAAGGCTTCACCAGTATATATTCTCACATATTCTTCGGCTTGAA AAACCTGCACTAGAATTTAAACCCACAGACGCGGACTCAGCCTACTGCGTTCTACCTCTT AATGTTGTTAATGACTCCAGCACTTTGGACATTGACTTTAAATTCATGGAAGATATCGAG AAATCTGAAGCTCGAATAGGCATTCCCAGCACAAAGTATTCAAAAGAAACTCCTTTTGTT TTCAAATTAGAAGATTACCAAGATGCAGTTATCATTCCAAGATACCGCAATTTTGATCAG CCTCATCGATTTTATGTCGCTGACGTGTACACTGATCTTACCCCCCTGAGTAAATTTCCT TCCCCTGAGTATGAAACGTTTGCGGAGTATTATAAAACAAAGTATAACCTTGACCTGACC AATCTCAACCAGCCGCTGCTGGACGTGGACCACACGTCTTCACGACTCAATCTTTTGACA CCTCGTCATTTGAATCAGAAGGGGAAAGCTCTCCCTCTGAGCAGTGCTGAGAAGAGGAAA GCCAAGTGGGAGAGCCTGCAGAATAAGCAGATACTGGTTCCAGAACTCTGTGCTATACAT CCAATTCCAGCATCACTGTGGAGAAAAGCCGTTTGTCTCCCGAGCATACTTTACCGCCTT CACTGCCTTCTGACTGCAGAGGAGCTCAGAGCCCAGACGGCCAGCGACGCTGGTGTGGGA GTCAGGTCACTTCCTGTGGATTTTAGATACCCTAACTTAGACTTCGGGTGGAAAAAATCT ATCGACAGCAAATCTTTCATCTCAATTGCTAACTCCTCTTCAGCTGAAAATGAGAATTAC TGTAAGCACAGCACAATTGTCGTCCCTGAAAATGCTGCACATCAAGGTGCTAATAGAACC TCCCCTCTAGAAAATCATGACCAAATGTCTGTGAACTGCAGAACGTTGTTCAGCGAGTCA CCTGGTAAGCTCCAAATTGAAGTTTCAACAGATCTGACAGCAATTAATGGTCTTTCTTAC AATAAAAGTCTTGCCAATGGCAGTTACGATTTAGCTAACAGAGACTTTTGCCAAGGAAAC CATCTGAATTACTACAAGCAGGAAATACCTGTACAACCAACTACCTCATATCCCATTCAG AATTTATACAATTACGAGAACCAGCCCAAGCCCAGCGATGAATGTACTCTACTGAGTAAT AAATACCTTGATGGAAATGCTAACACATCTACCTCAGATGGAAGTCCCGTGACGGCTGCC GTGCCTGGTACTACAGAGACTGGGGAGGCGCCCCCGGACAGGACGGCTTCTGAGCAGAGC CCTTCTCCTGGGTACTCCTCGAGGACGCTTGGCCCCAACCCTGGGCTCATTCTTCAGGCT TTGACCCTTTCGAACGCTAGTGATGGATTTAACCTGGAGCGGCTCGAGATGCTTGGCGAC TCCTTCCTCAAGCATGCCATCACCACCGTATCTCTTTCTGCACTTATCCTGGATGCGCAT GAGGGCCGCCTTTCCTACATGAGAAGCAAAAAGGTCAGCAACTGTAATCTGTATCGGCTT GGAAAAAAGAAGGGGCTGCCCAGCCGCATGGTGGTGTCCATATTTGACCCCCCTGTGAAT GGGCTTCCTCCTGGTTACGTAGTAAATCAAGACAAAAGTAACACAGAGAAATGGGAAAAA GATGAAATGACAAAAGACTGCATGTTGGCTAATGGCAAACTGGACGATGACTTCGAGGAG GAGGAAGAGGAGGAGGAGGACCTGATGTGGAGGGCTCACAAGGAGGATGCGGACGATGAG GACGACTTCCTGGAATACGATCAGGAGCACATCAAGTTCATAGATAACATGCTGATGGGG TCAGGGGCTTTCGTCAAGAAAATCTCTCTTTCTCCTTTTTCTGCCACCGATTCTGCATAC GAGTGGAAAATGCCCAAAAAGTCCTCCCTTGGTAGTCTGCCATTCTCATCCGATTTTGAG GATTTCGACTACAGCTCCTGGGATGCGATGTGCTATCTGGATCCGAGCAAAGCCGTTGAA GAGGATGACTTTGTGGTGGGGTTCTGGAATCCATCAGAAGAAAACTGTGGTGTGGACACA GGGAAGCAGTCCATCTCTTACGACCTGCACACCGAGCAGTGCATTGCCGACAAAAGCATA GCCGACTGTGTGGAAGCCCTGCTGGGCTGCTATTTAACCAGCTGTGGCGAGAGGGCTGCT CAGCTTTTCCTCTGTTCGCTGGGGCTGAAGGTGCTCCCGGTAATTAAAAGGACTGATCGG GAAAAGGCCATGTGCCCGACCAGGGAGAATTTCACCAGCCAACAAAAGAACCTTTCAGGG AGCCGTGCGGCTGCCTCTGGAGCCGGCTACCGAGCCTCTGTGTTGAAAGACTTGGAGTAT GGGTGTTTGAAGATCCCCCCGAGGTGTATGTTTGATCACCCCGAGGCAGACCGGACACTG CGTCACCTGATCTCGGGTTTTGAAAATTTCGAAAAGAAAATCAACTACAGATTCAAGAAT AAGGCTTACCTTCTACAGGCTTTTACACACGCCTCCTACCACTACAATACGATCACGGAT TGTTACCAGCGCTTAGAATTCCTGGGAGATGCAATTTTGGACTACCTCATAACTAAGCAC CTTTATGAAGACCCACGGCAGCACTCCCCAGGGGTCCTGACTGACCTGCGCTCTGCTCTG GTCAACAATACCATCTTCGCGTCTTTGGCTGTGAAGTATGACTACCACAAGTACTTTAAG GCCGTTTCTCCCGAGCTCTTCCATGTCATCGACGATTTCGTGCAGTTTCAGCTCGAGAAG AACGAAATGCAAGGAATGGATTCTGAGCTTAGGAGATCCGAGGAGGATGAAGAGAAGGAA GAGGATATTGAAGTTCCAAAGGCCATGGGGGATATTTTCGAGTCACTCGCGGGCGCCATT TACATGGACAGCGGGATGTCGCTGGAGACGGTCTGGCAGGTGTACTATCCCATGATGCGG CCGCTGATCGAAAAATTTTCTGCAAATGTGCCCCGTTCCCCTGTGCGAGAATTGCTTGAA ATGGAACCAGAAATTACCAAATTCAGCCCAGCTGAGAGAACCTACGATGGCAAGGTCAGA GTCACCGTGGAAGTGGTCGGGAAGGGGAAGTTCAAAGGCGTTGGCCGAAGTTACAGGATT GCCAAGTCTGCAGCAGCAAGAAGAGCCCTGCGAAGCCTCAAAGCTAATCAACCTCAGGTT CCCAATAGCTGA |
| Protein Properties | |
| Number of Residues | 1923 |
| Molecular Weight | 218258.0 |
| Theoretical pI | 5.46 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
|
| Protein Sequence |
>Endoribonuclease Dicer MKSPALQPLSMAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNT IVCLNTGSGKTFIAVLLTKELSYQIRGDFNRNGKRTVFLVNSANQVAQQVSAVRTHSDLK VGEYSNLEVSASWTKEKWNQEFTKHQVLIMTCYVALNVLKNGYLSLSDINLLVFDECHLA ILDHPYREIMKLCENCPSCPRILGLTASILNGKCDPEELEEKIQKLEKILKSNAETATDL VVLDRYTSQPCEIVVDCGPFTDRSGLYERLLMELEEALNFINDCNISVHSKERDSTLISK QILSDCRAVLVVLGPWCADKVAGMMVRELQKHIKHEQEELHRKFLLFTDTFLRKIHALCE EHFSPASLDLKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDEE DEEIEEKEKPETNFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFIT GHGIGKNQPRNKQMEAEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLP TEYRSYVQSKGRARAPISNYVMLADTDKIKSFEEDLKTYKAIEKILRNKCSKSVDTGEAD TEPVVDDDDVFPPYVLRPEDGPRVTINTAIGHVNRYCARLPSDPFTHLAPKCRTRELPDG TFYSTLYLPINSPLRASIVGPPMSCIRLAERVVALICCEKLHKIGELDDHLMPVGKETVK YEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPECLRESYPRPGQPCYLYVIGMVLTTPL PDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFTLSLQ MLELITRLHQYIFSHILRLEKPALEFKPTDADSAYCVLPLNVVNDSSTLDIDFKFMEDIE KSEARIGIPSTKYSKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFP SPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRK AKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTASDAGVG VRSLPVDFRYPNLDFGWKKSIDSKSFISIANSSSAENENYCKHSTIVVPENAAHQGANRT SPLENHDQMSVNCRTLFSESPGKLQIEVSTDLTAINGLSYNKSLANGSYDLANRDFCQGN HLNYYKQEIPVQPTTSYPIQNLYNYENQPKPSDECTLLSNKYLDGNANTSTSDGSPVTAA VPGTTETGEAPPDRTASEQSPSPGYSSRTLGPNPGLILQALTLSNASDGFNLERLEMLGD SFLKHAITTVSLSALILDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVN GLPPGYVVNQDKSNTEKWEKDEMTKDCMLANGKLDDDFEEEEEEEEDLMWRAHKEDADDE DDFLEYDQEHIKFIDNMLMGSGAFVKKISLSPFSATDSAYEWKMPKKSSLGSLPFSSDFE DFDYSSWDAMCYLDPSKAVEEDDFVVGFWNPSEENCGVDTGKQSISYDLHTEQCIADKSI ADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPVIKRTDREKAMCPTRENFTSQQKNLSG SRAAASGAGYRASVLKDLEYGCLKIPPRCMFDHPEADRTLRHLISGFENFEKKINYRFKN KAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSAL VNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQFQLEKNEMQGMDSELRRSEEDEEKE EDIEVPKAMGDIFESLAGAIYMDSGMSLETVWQVYYPMMRPLIEKFSANVPRSPVRELLE MEPEITKFSPAERTYDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLKANQPQV PNS |
| External Links | |
| GenBank ID Protein | AAR26432.1 |
| UniProtKB/Swiss-Prot ID | Q6TUI4 |
| UniProtKB/Swiss-Prot Entry Name | DICER_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | AY386968 |
| GeneCard ID | DICER1 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |