| Identification |
|---|
| BMDB Protein ID
| BMDBP00484 |
| Secondary Accession Numbers
| None |
| Name
| Endoribonuclease Dicer |
| Synonyms
|
Not Available
|
| Gene Name
| DICER1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Replication, recombination and repair |
| Specific Function
| Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 21 |
| Locus
| Not Available |
| SNPs
| DICER1 |
| Gene Sequence
|
>5772 bp
ATGAAAAGCCCTGCTTTGCAACCCCTCAGCATGGCAGGCCTGCAGCTCATGACCCCTGCT
TCCTCACCAATGGGTCCTTTCTTTGGACTGCCATGGCAACAAGAAGCAATTCATGATAAC
ATTTATACGCCAAGAAAATATCAGGTTGAACTGCTTGAAGCAGCTCTGGATCATAATACC
ATAGTCTGTTTAAACACTGGCTCAGGGAAGACGTTTATTGCAGTACTACTCACTAAAGAG
CTGTCTTATCAGATCAGGGGAGACTTCAACAGAAATGGCAAAAGGACGGTGTTCTTGGTC
AACTCTGCAAACCAGGTTGCCCAACAAGTGTCAGCTGTCAGAACTCACTCAGATCTCAAG
GTCGGGGAATACTCAAACCTAGAAGTAAGTGCATCTTGGACAAAAGAGAAATGGAACCAA
GAGTTTACTAAGCACCAGGTTCTCATTATGACCTGCTATGTCGCCTTGAATGTTTTGAAA
AATGGTTACTTATCACTGTCAGACATTAACCTTTTGGTGTTTGATGAGTGTCATCTTGCA
ATCCTAGACCACCCCTACCGAGAAATTATGAAGCTTTGTGAAAATTGTCCATCATGTCCT
CGTATTTTGGGACTAACTGCTTCCATTTTAAATGGGAAATGTGATCCAGAGGAATTGGAA
GAGAAGATTCAGAAACTGGAGAAAATTCTTAAGAGTAATGCTGAAACTGCAACTGACTTG
GTGGTCTTAGACAGATATACTTCTCAGCCATGTGAGATTGTGGTAGACTGTGGACCATTT
ACTGACAGAAGTGGGCTTTATGAAAGACTGCTGATGGAGTTAGAAGAAGCACTTAATTTT
ATCAATGACTGTAACATATCTGTACATTCAAAAGAAAGAGATTCTACTTTAATTTCTAAA
CAGATACTCTCAGACTGCCGTGCGGTCCTGGTTGTCCTGGGACCCTGGTGTGCCGATAAA
GTAGCTGGAATGATGGTCAGAGAGCTGCAGAAACACATCAAACATGAGCAGGAGGAGCTG
CACCGGAAGTTTCTGTTGTTCACAGACACTTTCCTACGGAAAATCCACGCCCTGTGTGAA
GAGCACTTCTCCCCTGCCTCGCTTGACCTGAAGTTTGTCACTCCTAAAGTAATAAAGCTG
CTCGAGATCTTACGCAAATACAAACCGTATGAGCGGCAGCAGTTTGAAAGCGTGGAGTGG
TATAATAATAGGAACCAGGATAATTACGTGTCCTGGAGCGATTCTGAGGATGACGAGGAA
GATGAAGAGATTGAAGAGAAAGAAAAGCCAGAGACAAATTTTCCTTCTCCGTTTACCAAC
ATTTTGTGTGGAATTATTTTTGTGGAAAGAAGATACACAGCCGTGGTCTTAAACAGATTG
ATAAAGGAAGCTGGCAAACAAGATCCAGAGCTGGCTTACATCAGCAGCAATTTTATAACT
GGACATGGCATCGGAAAGAATCAGCCTCGGAACAAACAGATGGAAGCGGAATTCAGAAAA
CAGGAAGAGGTACTTAGGAAATTTCGAGCACATGAAACCAACCTGCTTATTGCAACAAGT
ATTGTGGAGGAGGGTGTTGACATACCGAAATGCAACTTGGTGGTTCGTTTCGATCTGCCC
ACAGAGTATCGATCCTACGTTCAGTCCAAGGGAAGAGCGAGGGCACCCATCTCTAATTAT
GTAATGTTAGCAGACACAGATAAAATAAAGAGTTTTGAAGAAGACCTTAAAACATACAAA
GCTATTGAAAAGATCTTGCGAAACAAATGTTCCAAGTCGGTTGATACCGGGGAGGCCGAC
ACGGAGCCCGTGGTGGATGACGACGATGTTTTCCCACCGTATGTGCTGAGGCCTGAGGAC
GGTCCCCGCGTCACGATCAACACGGCCATTGGGCACGTCAACAGATACTGTGCTAGATTA
CCAAGTGATCCGTTTACTCATCTGGCTCCTAAATGTAGAACCCGAGAGTTGCCTGATGGT
ACATTTTATTCAACTCTTTATCTGCCAATTAACTCACCTCTTCGAGCCTCCATTGTTGGT
CCCCCAATGAGCTGCATTCGGTTGGCTGAAAGAGTCGTGGCTCTCATTTGCTGTGAAAAA
CTGCACAAAATTGGCGAACTGGATGACCATTTGATGCCAGTTGGGAAGGAGACTGTTAAA
TATGAGGAAGAGCTGGATTTACACGATGAAGAAGAGACCAGTGTTCCAGGAAGACCAGGT
TCCACAAAACGAAGACAGTGCTACCCAAAAGCAATTCCAGAATGTTTGAGGGAGAGCTAC
CCCAGGCCTGGTCAGCCCTGTTACCTGTACGTGATCGGAATGGTCCTGACGACACCTTTA
CCTGATGAGCTCAACTTCAGAAGGCGGAAGCTCTACCCCCCTGAGGACACCACAAGATGC
TTTGGAATACTGACAGCCAAGCCCATACCTCAGATCCCACACTTTCCTGTGTACACGCGC
TCTGGAGAGGTGACCATATCTATTGAGTTGAAGAAGTCCGGCTTCACGTTATCTCTGCAA
ATGCTTGAGTTGATCACAAGGCTTCACCAGTATATATTCTCACATATTCTTCGGCTTGAA
AAACCTGCACTAGAATTTAAACCCACAGACGCGGACTCAGCCTACTGCGTTCTACCTCTT
AATGTTGTTAATGACTCCAGCACTTTGGACATTGACTTTAAATTCATGGAAGATATCGAG
AAATCTGAAGCTCGAATAGGCATTCCCAGCACAAAGTATTCAAAAGAAACTCCTTTTGTT
TTCAAATTAGAAGATTACCAAGATGCAGTTATCATTCCAAGATACCGCAATTTTGATCAG
CCTCATCGATTTTATGTCGCTGACGTGTACACTGATCTTACCCCCCTGAGTAAATTTCCT
TCCCCTGAGTATGAAACGTTTGCGGAGTATTATAAAACAAAGTATAACCTTGACCTGACC
AATCTCAACCAGCCGCTGCTGGACGTGGACCACACGTCTTCACGACTCAATCTTTTGACA
CCTCGTCATTTGAATCAGAAGGGGAAAGCTCTCCCTCTGAGCAGTGCTGAGAAGAGGAAA
GCCAAGTGGGAGAGCCTGCAGAATAAGCAGATACTGGTTCCAGAACTCTGTGCTATACAT
CCAATTCCAGCATCACTGTGGAGAAAAGCCGTTTGTCTCCCGAGCATACTTTACCGCCTT
CACTGCCTTCTGACTGCAGAGGAGCTCAGAGCCCAGACGGCCAGCGACGCTGGTGTGGGA
GTCAGGTCACTTCCTGTGGATTTTAGATACCCTAACTTAGACTTCGGGTGGAAAAAATCT
ATCGACAGCAAATCTTTCATCTCAATTGCTAACTCCTCTTCAGCTGAAAATGAGAATTAC
TGTAAGCACAGCACAATTGTCGTCCCTGAAAATGCTGCACATCAAGGTGCTAATAGAACC
TCCCCTCTAGAAAATCATGACCAAATGTCTGTGAACTGCAGAACGTTGTTCAGCGAGTCA
CCTGGTAAGCTCCAAATTGAAGTTTCAACAGATCTGACAGCAATTAATGGTCTTTCTTAC
AATAAAAGTCTTGCCAATGGCAGTTACGATTTAGCTAACAGAGACTTTTGCCAAGGAAAC
CATCTGAATTACTACAAGCAGGAAATACCTGTACAACCAACTACCTCATATCCCATTCAG
AATTTATACAATTACGAGAACCAGCCCAAGCCCAGCGATGAATGTACTCTACTGAGTAAT
AAATACCTTGATGGAAATGCTAACACATCTACCTCAGATGGAAGTCCCGTGACGGCTGCC
GTGCCTGGTACTACAGAGACTGGGGAGGCGCCCCCGGACAGGACGGCTTCTGAGCAGAGC
CCTTCTCCTGGGTACTCCTCGAGGACGCTTGGCCCCAACCCTGGGCTCATTCTTCAGGCT
TTGACCCTTTCGAACGCTAGTGATGGATTTAACCTGGAGCGGCTCGAGATGCTTGGCGAC
TCCTTCCTCAAGCATGCCATCACCACCGTATCTCTTTCTGCACTTATCCTGGATGCGCAT
GAGGGCCGCCTTTCCTACATGAGAAGCAAAAAGGTCAGCAACTGTAATCTGTATCGGCTT
GGAAAAAAGAAGGGGCTGCCCAGCCGCATGGTGGTGTCCATATTTGACCCCCCTGTGAAT
GGGCTTCCTCCTGGTTACGTAGTAAATCAAGACAAAAGTAACACAGAGAAATGGGAAAAA
GATGAAATGACAAAAGACTGCATGTTGGCTAATGGCAAACTGGACGATGACTTCGAGGAG
GAGGAAGAGGAGGAGGAGGACCTGATGTGGAGGGCTCACAAGGAGGATGCGGACGATGAG
GACGACTTCCTGGAATACGATCAGGAGCACATCAAGTTCATAGATAACATGCTGATGGGG
TCAGGGGCTTTCGTCAAGAAAATCTCTCTTTCTCCTTTTTCTGCCACCGATTCTGCATAC
GAGTGGAAAATGCCCAAAAAGTCCTCCCTTGGTAGTCTGCCATTCTCATCCGATTTTGAG
GATTTCGACTACAGCTCCTGGGATGCGATGTGCTATCTGGATCCGAGCAAAGCCGTTGAA
GAGGATGACTTTGTGGTGGGGTTCTGGAATCCATCAGAAGAAAACTGTGGTGTGGACACA
GGGAAGCAGTCCATCTCTTACGACCTGCACACCGAGCAGTGCATTGCCGACAAAAGCATA
GCCGACTGTGTGGAAGCCCTGCTGGGCTGCTATTTAACCAGCTGTGGCGAGAGGGCTGCT
CAGCTTTTCCTCTGTTCGCTGGGGCTGAAGGTGCTCCCGGTAATTAAAAGGACTGATCGG
GAAAAGGCCATGTGCCCGACCAGGGAGAATTTCACCAGCCAACAAAAGAACCTTTCAGGG
AGCCGTGCGGCTGCCTCTGGAGCCGGCTACCGAGCCTCTGTGTTGAAAGACTTGGAGTAT
GGGTGTTTGAAGATCCCCCCGAGGTGTATGTTTGATCACCCCGAGGCAGACCGGACACTG
CGTCACCTGATCTCGGGTTTTGAAAATTTCGAAAAGAAAATCAACTACAGATTCAAGAAT
AAGGCTTACCTTCTACAGGCTTTTACACACGCCTCCTACCACTACAATACGATCACGGAT
TGTTACCAGCGCTTAGAATTCCTGGGAGATGCAATTTTGGACTACCTCATAACTAAGCAC
CTTTATGAAGACCCACGGCAGCACTCCCCAGGGGTCCTGACTGACCTGCGCTCTGCTCTG
GTCAACAATACCATCTTCGCGTCTTTGGCTGTGAAGTATGACTACCACAAGTACTTTAAG
GCCGTTTCTCCCGAGCTCTTCCATGTCATCGACGATTTCGTGCAGTTTCAGCTCGAGAAG
AACGAAATGCAAGGAATGGATTCTGAGCTTAGGAGATCCGAGGAGGATGAAGAGAAGGAA
GAGGATATTGAAGTTCCAAAGGCCATGGGGGATATTTTCGAGTCACTCGCGGGCGCCATT
TACATGGACAGCGGGATGTCGCTGGAGACGGTCTGGCAGGTGTACTATCCCATGATGCGG
CCGCTGATCGAAAAATTTTCTGCAAATGTGCCCCGTTCCCCTGTGCGAGAATTGCTTGAA
ATGGAACCAGAAATTACCAAATTCAGCCCAGCTGAGAGAACCTACGATGGCAAGGTCAGA
GTCACCGTGGAAGTGGTCGGGAAGGGGAAGTTCAAAGGCGTTGGCCGAAGTTACAGGATT
GCCAAGTCTGCAGCAGCAAGAAGAGCCCTGCGAAGCCTCAAAGCTAATCAACCTCAGGTT
CCCAATAGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1923 |
| Molecular Weight
| 218258.0 |
| Theoretical pI
| 5.46 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 34-54
- 63-83
- 95-120
- 125-145
- 150-170
- 176-196
- 595-615
- 620-640
- 669-688
- 718-737
- 746-773
- 792-812
|
| Protein Sequence
|
>Endoribonuclease Dicer
MKSPALQPLSMAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNT
IVCLNTGSGKTFIAVLLTKELSYQIRGDFNRNGKRTVFLVNSANQVAQQVSAVRTHSDLK
VGEYSNLEVSASWTKEKWNQEFTKHQVLIMTCYVALNVLKNGYLSLSDINLLVFDECHLA
ILDHPYREIMKLCENCPSCPRILGLTASILNGKCDPEELEEKIQKLEKILKSNAETATDL
VVLDRYTSQPCEIVVDCGPFTDRSGLYERLLMELEEALNFINDCNISVHSKERDSTLISK
QILSDCRAVLVVLGPWCADKVAGMMVRELQKHIKHEQEELHRKFLLFTDTFLRKIHALCE
EHFSPASLDLKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDEE
DEEIEEKEKPETNFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFIT
GHGIGKNQPRNKQMEAEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLP
TEYRSYVQSKGRARAPISNYVMLADTDKIKSFEEDLKTYKAIEKILRNKCSKSVDTGEAD
TEPVVDDDDVFPPYVLRPEDGPRVTINTAIGHVNRYCARLPSDPFTHLAPKCRTRELPDG
TFYSTLYLPINSPLRASIVGPPMSCIRLAERVVALICCEKLHKIGELDDHLMPVGKETVK
YEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPECLRESYPRPGQPCYLYVIGMVLTTPL
PDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFTLSLQ
MLELITRLHQYIFSHILRLEKPALEFKPTDADSAYCVLPLNVVNDSSTLDIDFKFMEDIE
KSEARIGIPSTKYSKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFP
SPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRK
AKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTASDAGVG
VRSLPVDFRYPNLDFGWKKSIDSKSFISIANSSSAENENYCKHSTIVVPENAAHQGANRT
SPLENHDQMSVNCRTLFSESPGKLQIEVSTDLTAINGLSYNKSLANGSYDLANRDFCQGN
HLNYYKQEIPVQPTTSYPIQNLYNYENQPKPSDECTLLSNKYLDGNANTSTSDGSPVTAA
VPGTTETGEAPPDRTASEQSPSPGYSSRTLGPNPGLILQALTLSNASDGFNLERLEMLGD
SFLKHAITTVSLSALILDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVN
GLPPGYVVNQDKSNTEKWEKDEMTKDCMLANGKLDDDFEEEEEEEEDLMWRAHKEDADDE
DDFLEYDQEHIKFIDNMLMGSGAFVKKISLSPFSATDSAYEWKMPKKSSLGSLPFSSDFE
DFDYSSWDAMCYLDPSKAVEEDDFVVGFWNPSEENCGVDTGKQSISYDLHTEQCIADKSI
ADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPVIKRTDREKAMCPTRENFTSQQKNLSG
SRAAASGAGYRASVLKDLEYGCLKIPPRCMFDHPEADRTLRHLISGFENFEKKINYRFKN
KAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSAL
VNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQFQLEKNEMQGMDSELRRSEEDEEKE
EDIEVPKAMGDIFESLAGAIYMDSGMSLETVWQVYYPMMRPLIEKFSANVPRSPVRELLE
MEPEITKFSPAERTYDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLKANQPQV
PNS
|
| External Links |
|---|
| GenBank ID Protein
| AAR26432.1 |
| UniProtKB/Swiss-Prot ID
| Q6TUI4 |
| UniProtKB/Swiss-Prot Entry Name
| DICER_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY386968 |
| GeneCard ID
| DICER1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
