| Identification |
|---|
| BMDB Protein ID
| BMDBP00492 |
| Secondary Accession Numbers
| None |
| Name
| General transcription and DNA repair factor IIH helicase subunit XPD |
| Synonyms
|
Not Available
|
| Gene Name
| ERCC2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Transcription |
| Specific Function
| ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/ERCC2 is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. XPD/ERCC2 acts by forming a bridge between CAK and the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers. |
| Pathways
|
- Nucleotide Excision Repair
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| Not Available |
| SNPs
| ERCC2 |
| Gene Sequence
|
>2283 bp
ATGAAGCTCAACGTGGACGGGCTGCTGGTCTACTTCCCCTACGACTACATCTACCCGGAG
CAGTTCTCGTACATGCTGGAGCTCAAACGCACGCTGGATGCCAAGGGTCATGGAGTCCTG
GAGATGCCCTCAGGCACTGGGAAGACAGTGTCCCTGTTGGCCCTGATCATGGCGTACCAG
CGGGCGTATCCCCTGGAGGTGACTAAACTCATCTACTGCTCGAGGACTGTGCCTGAGATT
GAAAAGGTGATTGAAGAACTTCGAAAGTTACTCAGCTTCTATGAGAAACAGGAGGGCGAG
AAGCTGCCATTTTTGGGGCTGGCTCTGAGCTCCCGGAAGAACCTGTGTATTCATCCCGAG
GTGACGCCCCTGCGCTTTGGGAAGGACGTGGACGGGAAATGCCACAGCCTCACGGCATCG
TACGTGCGGGCACAGTACCAGCGGGACTCCAGCCTGCCCCACTGCCGCTTCTACGAGGAA
TTTGATGTCCACGGGCGCCAGGTGCCCCTCCCCACGGGCATCTACAACCTAGATGACCTG
AAGGCTGTGGGACGGCGCCAGGGCTGGTGCCCGTACTTCCTGGCCCGATACTCAATCCTG
CACGCCAACGTGGTGGTCTACAGCTACCACTACCTGCTGGACCCCAAGATTGCTGACCTG
GTGTCCAAGGAGCTGGCCCGCAAGGCCGTGGTCGTCTTTGATGAGGCCCACAACATCGAC
AACGTCTGCATCGACTCCATGAGCGTCAACCTCACCCGCCGCACCCTGGATCGGTGCCAG
GCCAACCTGGAGACCCTGCAGAAGACGGTGCTCAGAATCAAGGAGACGGACGAGCAGCGA
CTGCGAGAGGAGTACCGCCGCCTGGTGGAGGGGCTGCGGGAGGCCAGCGCTGCCCGGGAG
ACCGATGCCCACCTGGCCAACCCCGTGCTGCCTGACGAAGTGCTAAAGGAGGCGGTGCCT
GGCTCCATCCGCACGGCCGAGCACTTCCTGGGCTTCCTGCGCCGCCTGTTGGAGTACGTC
AAGTGGCGCCTGCGGGTGCAGCATGTGGTCCAGGAGAGCCCGCCCGCCTTCCTCAGTGGC
CTGGCCCAGCGCGTCTGCATCCAGCGCAAGCCCCTCAGGTTCTGCGCCGAGCGCCTCCGC
TCCCTCCTGTACACCTTGGAGATCTCGGACCTCACTGACTTCTCCCCACTCACCCTCCTC
GCTAACTTCGCCACGCTCGTCAGCACCTATGCCAAGGGTTTCACCATCATCATCGAGCCG
TTCGATGACAGGACCCCGACCATTGCCAACCCCATCCTGCACTTCAGCTGCATGGACGCC
TCACTGGCCATCAAACCTGTGTTTGAGCGCTTCCAGTCCGTCATCATCACATCTGGGACA
CTGTCCCCACTGGACATCTACCCCAAGATCCTGGACTTCCACCCTGTCACCATGGCAACC
TTCACCATGACGTTGGCCCGGGTCTGCCTCTGCCCCATGATCATCGGCCGTGGCAATGAC
CAGGTGGCCATCAGCTCCAAGTTTGAGACCCGGGAAGATATTGCGGTGATCCGGAACTAT
GGAAATCTCCTGCTGGAGATGTCTGCCGTGGTCCCTGACGGCATCGTGGCCTTCTTCACC
AGCTACCAATACATGGAGAGCACTGTGGCCTCCTGGTACGAGCAGGGCATCCTGGAGAAC
ATCCAGAGGAACAAGCTGCTCTTCATCGAGACCCAGGATGGGGCTGAGACCAGCGTCGCC
CTAGAGAAGTACCAGGAGGCCTGCGAGAACGGCCGCGGGGCCATCCTGCTCTCGGTGGCC
CGAGGCAAGGTGTCCGAGGGAATCGACTTTGTGCACCACTACGGGCGGGCCGTCATCATG
TTCGGGGTGCCCTACGTGTACACCCAGAGCCGCATTCTCAAGGCACGGCTGGAATACCTT
CGGGACCAGTTCCAGATTCGTGAGAATGACTTTCTCACCTTTGATGCCATGCGCCATGCT
GCCCAGTGTGTGGGTCGGGCCATCAGGGGCAAGACGGACTATGGCCTGATGGTCTTTGCC
GACAAGCGGTTTGCTCGGGCTGACAAGCGGGGGAAGCTACCCCGGTGGATCCAGGAGCAC
CTCACGGACGCCAACCTCAACCTGACCGTCGACGAGGGGGTCCAAGTCGCCAAGTACTTC
CTGAGGCAGATGGCACAGCCCTTCCACCGGGAGGACCAGCTGGGCCTGTCCCTGCTCAGC
CTGGAGCAGCTGGAGTCAGAGGAGACGCTGCGGAGGATCGAGCAGATTGCCCAGCAGCTA
TAG
|
| Protein Properties |
|---|
| Number of Residues
| 760 |
| Molecular Weight
| 86999.0 |
| Theoretical pI
| 7.38 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>TFIIH basal transcription factor complex helicase subunit
MKLNVDGLLVYFPYDYIYPEQFSYMLELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQ
RAYPLEVTKLIYCSRTVPEIEKVIEELRKLLSFYEKQEGEKLPFLGLALSSRKNLCIHPE
VTPLRFGKDVDGKCHSLTASYVRAQYQRDSSLPHCRFYEEFDVHGRQVPLPTGIYNLDDL
KAVGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNID
NVCIDSMSVNLTRRTLDRCQANLETLQKTVLRIKETDEQRLREEYRRLVEGLREASAARE
TDAHLANPVLPDEVLKEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSG
LAQRVCIQRKPLRFCAERLRSLLYTLEISDLTDFSPLTLLANFATLVSTYAKGFTIIIEP
FDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMAT
FTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFT
SYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVA
RGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHA
AQCVGRAIRGKTDYGLMVFADKRFARADKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYF
LRQMAQPFHREDQLGLSLLSLEQLESEETLRRIEQIAQQL
|
| External Links |
|---|
| GenBank ID Protein
| AAI47983.1 |
| UniProtKB/Swiss-Prot ID
| A6QLJ0 |
| UniProtKB/Swiss-Prot Entry Name
| ERCC2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC147982 |
| GeneCard ID
| ERCC2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
