| Identification |
|---|
| BMDB Protein ID
| BMDBP00495 |
| Secondary Accession Numbers
| None |
| Name
| Adenylosuccinate synthetase isozyme 1 |
| Synonyms
|
Not Available
|
| Gene Name
| ADSS1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Nucleotide transport and metabolism |
| Specific Function
| Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. |
| Pathways
|
- AMP biosynthesis via de novo pathway
- AMP from IMP: step 1/2
- Aspartate Metabolism
- Purine Metabolism
|
| Reactions
|
| Guanosine triphosphate + Inosinic acid + L-Aspartic acid → Guanosine diphosphate + Hydrogen phosphate + Adenylsuccinic acid |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 21 |
| Locus
| Not Available |
| SNPs
| ADSS1 |
| Gene Sequence
|
>1374 bp
ATGTCCGGGACCCGAGCCTCTAACGATCGGCCCCCCAGCGCGGGCGGCGTCAAGCGGGGG
CGGCTACAGCACGAGGCGGCGACCACCGGCTCCCGGGTGACCGTGGTGCTGGGCGCGCAG
TGGGGGGACGAGGGCAAAGGCAAGGTGGTGGACCTGCTGGCCACGGACGCCGACGTCGTC
AGCCGCTGCCAGGGAGGCAACAATGCTGGCCACACCGTGGTGGTGGATGGCAAGGAGTAC
GACTTCCACCTGCTGCCCAGTGGCATCATCAACCCCAAGGCCGTGTCCTTCATCGGCAAT
GGAGTGGTCGTCCACTTGCCGGGCTTGTTTGAAGAGGCAGAGAAGAACGAGAAGAAAGGC
CTGAAGGACTGGGAGAAGAGGCTCGTCATCTCTGACCGGGCCCACCTTGTGTTTGACTTT
CACCAGGCGGTGGACGGGCTCCAGGAGGTGCAGCGGCAGGCCCAGGAGGGCAAGAACATC
GGCACGACCCGGAAGGGGATCGGGCCGGCCTACTCGTCCAAGGCCGCCCGCACCGGCCTC
CGCATCTGCGACCTCCTGTCTGACTTCGACGAGTTCTCCTCCCGATTCAAGAACCTGGCA
CGCCAGCACCAGTCCATGTTCCCCAGTTTGGAAGTGGACGTTGAAGGTCAACTCAAAAGG
CTCAAGGGCTTCGCCGAGCGGATCCGCCCCATGGTCCGAGATGGCGTTTATTTCATGTAT
GAGGCGCTCCATGGCCCCCCTAAGAAGATCCTCGTGGAGGGTGCCAACGCAGCCCTCCTT
GACATTGACTTCGGGACCTACCCCTTCGTGACGTCCTCCAACTGCACGGTGGGCGGCGTG
TGCACCGGCCTGGGCATCCCGCCCCAGAACATAGGCGAGGTCTACGGTGTGGTCAAGGCC
TACACCACACGCGTGGGCATCGGCGCCTTCCCCACCGAGCAGATCAACGAGATCGGGGAC
CTGCTGCAGAGCCGCGGCCACGAGTGGGGCGTGACCACGGGCAGGAAGCGGCGCTGCGGC
TGGCTGGATCTGATGATCCTGAGATATGCCCACATGGTCAACGGATTCACCGCGCTGGCC
TTGACGAAACTGGACATCCTGGACGCCCTGGACGAGATCAAGGTCGGCGTGGCGTACAAG
CTTGGCGGGAAGCGGATCCCCTACTTCCCAGCCAACCAGGAGATCCTGCAGAAGGTGGAG
GTGGAATACGAGACGCTGCCAGGGTGGAAGGCGGACACCACGGGCGCCCGGAAGTGGGAG
GACCTCCCCCCGCAGGCCCAGAGCTACATCCGGTTCGTGGAGAACCACGTCGGCGTGGCA
GTGAAATGGGTTGGTGTCGGCAAGTCCAGAGATTCGATGATCCAGCTGTTTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 457 |
| Molecular Weight
| 50134.0 |
| Theoretical pI
| 8.65 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Adenylosuccinate synthetase isozyme 1
MSGTRASNDRPPSAGGVKRGRLQHEAATTGSRVTVVLGAQWGDEGKGKVVDLLATDADVV
SRCQGGNNAGHTVVVDGKEYDFHLLPSGIINPKAVSFIGNGVVVHLPGLFEEAEKNEKKG
LKDWEKRLVISDRAHLVFDFHQAVDGLQEVQRQAQEGKNIGTTRKGIGPAYSSKAARTGL
RICDLLSDFDEFSSRFKNLARQHQSMFPSLEVDVEGQLKRLKGFAERIRPMVRDGVYFMY
EALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGEVYGVVKA
YTTRVGIGAFPTEQINEIGDLLQSRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALA
LTKLDILDALDEIKVGVAYKLGGKRIPYFPANQEILQKVEVEYETLPGWKADTTGARKWE
DLPPQAQSYIRFVENHVGVAVKWVGVGKSRDSMIQLF
|
| External Links |
|---|
| GenBank ID Protein
| AAI42212.1 |
| UniProtKB/Swiss-Prot ID
| A5PJR4 |
| UniProtKB/Swiss-Prot Entry Name
| PURA1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC142211 |
| GeneCard ID
| ADSS1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
