| Identification |
|---|
| BMDB Protein ID
| BMDBP00501 |
| Secondary Accession Numbers
| None |
| Name
| Thioredoxin reductase 2, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| TXNRD2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (By similarity). Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling. |
| Pathways
|
- Glutamate Metabolism
- Glutathione Metabolism
|
| Reactions
|
| Oxidized glutathione + NADPH →2 Glutathione + NADP |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| Not Available |
| SNPs
| TXNRD2 |
| Gene Sequence
|
>1536 bp
ATGGCGGCGCTGCGCGGAGCGGCCGCGCGTTTCCGGGGCCGCGCGCCGGGAGGGGCGCGG
GGCGCCGCAGGCCGGCAGTGCTACGACCTCCTGGTGATCGGCGGCGGATCCGGCGGCCTG
GCCTGCGCCAAGGAAGCCGCCCAGCTGGGGAAGAAGGTGGCCGTGCTGGACTACGTGGAG
CCTTCCCCCCAAGGCACCAGGTGGGGCCTTGGCGGCACCTGCGTGAACGTCGGCTGCATC
CCCAAGAAACTGATGCACCAGGCGGCCCTGCTGGGGGGCATGATCCGCGACGCTCCCCAC
TATGGCTGGGGCGTGGCCCAGGCCCCGCACAGCTGGGCGACGCTGGCGGACGCTGTTCAG
AACCACGTGAAGTCCCTGAACTGGGGCCACCGCATCCAGCTGCAGGACAGGAAAGTCAAG
TATTTTAACGTCAAGGCCAGCTTTGTCGACACGCACACAGTTTGCGGTGTCTCCAAAGGC
GGGGAGGAGACTCTGCTTTCGGCCGAGCACATTGTCATCGCCACCGGAGGTCGGCCGCGG
TACCCCACGCACATCGAAGGTGCCTTGGAATATGGGATCACGAGTGATGACCTCTTCTGG
CTGAAGGAATCCCCTGGGAAAACGTTGGTGGTCGGGGCCAGCTACGTAGCCCTGGAGTGC
GCGGGCCTCCTCACCGGGCTCGGCTTGGACACCACCGTCATGATACGCAGCGTGCCCCTC
CGGGCCTTCGACCAGCAAATGGCTTCGCTGGTCACCGAGCACATGGCTGGCCACGGCACC
CGGATCCTACGGGGCTGCGCCCCCGAGAAGGTAGAGAAACTCCCAGGCCAGCAGCTCCGC
GTCACCTGGGTGGACCTCACCTCGGACCGGAAGGACGCGGGCACCTTTGACACGGTGCTC
TGGGCCATAGGCCGAGTTCCAGAAACCGCAAGTCTGAATTTGGAAAAGGCTGGTGTGCAT
ACGAACCCCGTCACTGGGAAGATCCTCGTTGATGCCCAGGAAACCACCTCCGTCCCCCAC
ATCTATGCCATCGGTGATGTGGCAGAGGGGCGGCCGGAGCTGACGCCCACGGCCATCATG
GCCGGGCGGCTCCTGGCCCAGCGGCTGAGCGGCCGGACCTCAGACCTGATGGACTACAGC
AGCGTCCCCACGACTGTCTTCACCCCGCTGGAGTACGGCTGCGTGGGGCTGTCAGAGGAG
GCAGCCGTGGCTCGCCATGGAGAAGAGCACGTGGAGGTTTACCACGCGTTCTATAAACCA
CTGGAGTTCACTGTCCCCCAGCGGGATGCATCTCAGTGCTACATAAAGATGGTGTGTCTG
CGGGAGCCCCCACAGCTGGTGCTGGGCCTGCACTTCCTCGGCCCCAACGCAGGCGAAGTT
ATTCAGGGATTTGCCCTGGGGATCAAGTGTGGGGCCTCCTACCAGCAGCTGATGCGGACA
GTGGGCATCCACCCCACCTGTGCGGAGGAGGTGGCCAAGCTCCGCATCTCCAAGCGCTCT
GGCCTGGACCCCACAGTAACCGGCTGCTGAGGCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 511 |
| Molecular Weight
| 54670.0 |
| Theoretical pI
| 8.01 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Thioredoxin reductase 2, mitochondrial
MAALRGAAARFRGRAPGGARGAAGRQCYDLLVIGGGSGGLACAKEAAQLGKKVAVLDYVE
PSPQGTRWGLGGTCVNVGCIPKKLMHQAALLGGMIRDAPHYGWGVAQAPHSWATLADAVQ
NHVKSLNWGHRIQLQDRKVKYFNVKASFVDTHTVCGVSKGGEETLLSAEHIVIATGGRPR
YPTHIEGALEYGITSDDLFWLKESPGKTLVVGASYVALECAGLLTGLGLDTTVMIRSVPL
RAFDQQMASLVTEHMAGHGTRILRGCAPEKVEKLPGQQLRVTWVDLTSDRKDAGTFDTVL
WAIGRVPETASLNLEKAGVHTNPVTGKILVDAQETTSVPHIYAIGDVAEGRPELTPTAIM
AGRLLAQRLSGRTSDLMDYSSVPTTVFTPLEYGCVGLSEEAAVARHGEEHVEVYHAFYKP
LEFTVPQRDASQCYIKMVCLREPPQLVLGLHFLGPNAGEVIQGFALGIKCGASYQQLMRT
VGIHPTCAEEVAKLRISKRSGLDPTVTGCUG
|
| External Links |
|---|
| GenBank ID Protein
| BAA82153.1 |
| UniProtKB/Swiss-Prot ID
| Q9N2I8 |
| UniProtKB/Swiss-Prot Entry Name
| TRXR2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB022283 |
| GeneCard ID
| TXNRD2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
