Showing Protein Inosine triphosphate pyrophosphatase (BMDBP00508)
| Identification | |||||||
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| BMDB Protein ID | BMDBP00508 | ||||||
| Secondary Accession Numbers | None | ||||||
| Name | Inosine triphosphate pyrophosphatase | ||||||
| Synonyms | Not Available | ||||||
| Gene Name | ITPA | ||||||
| Protein Type | Enzyme | ||||||
| Biological Properties | |||||||
| General Function | Nucleotide transport and metabolism | ||||||
| Specific Function | Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. | ||||||
| Pathways |
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| Reactions |
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| GO Classification | Not Available | ||||||
| Cellular Location | Not Available | ||||||
| Gene Properties | |||||||
| Chromosome Location | 13 | ||||||
| Locus | Not Available | ||||||
| SNPs | ITPA | ||||||
| Gene Sequence |
>627 bp ATGGCGGCCTCCTTGGCCGGGAAGAAGATCGTGTTTGTCACGGGGAACGCCAAAAAGCTG GAGGAGGTCATTCAGATTCTAGGAGATAAATTTCCGTGTACTTTGGTGGCGCAGAAAATT GACCTGCCAGAGTACCAAGGAGAGCCTGATGAGATTTCCATTCGGAAGTGTCAGGAGGCA GCTCGCCAGGTGCAGGGCCCTGTACTGGTAGAGGACACCTGTCTGTGCTTCAACGCCCTT GGAGGCCTCCCTGGCCCCTACATAAAGTGGTTTCTGGAGAAGTTAAAGCCTGAAGGTCTC CACCAGCTCCTGGAGGGGTTCCAAGACAAGTCTGCCTATGCACTCTGCACGTTCGCATTC AGCACTGGGGACCCGAATGAGCCCGTACGCCTCTTCAGGGGCCGGACAATGGGCCGGATT GTGGTGCCCCGTGGCTGCCGGGACTTTGGCTGGGACCCCTGCTTTCAGCCTGATGGATAC GAGCAGACGTATGCAGAGATGCCCAAGGCTGAGAAGAACACCATTTCCCATCGCTTCCGG GCCCTGCTTGCGTTGCAAGAATATTTTAGCAGCCTGACTCCTGGGGTCGGTGATGACCAC CCTAGCTGGGGATCCGGAGAGGGGTAG |
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| Protein Properties | |||||||
| Number of Residues | 208 | ||||||
| Molecular Weight | 23061.0 | ||||||
| Theoretical pI | 5.36 | ||||||
| Pfam Domain Function | Not Available | ||||||
| Signals |
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| Transmembrane Regions | Not Available | ||||||
| Protein Sequence |
>Inosine triphosphate pyrophosphatase MAASLAGKKIVFVTGNAKKLEEVIQILGDKFPCTLVAQKIDLPEYQGEPDEISIRKCQEA ARQVQGPVLVEDTCLCFNALGGLPGPYIKWFLEKLKPEGLHQLLEGFQDKSAYALCTFAF STGDPNEPVRLFRGRTMGRIVVPRGCRDFGWDPCFQPDGYEQTYAEMPKAEKNTISHRFR ALLALQEYFSSLTPGVGDDHPSWGSGEG |
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| External Links | |||||||
| GenBank ID Protein | AAI12689.1 | ||||||
| UniProtKB/Swiss-Prot ID | Q2KIC5 | ||||||
| UniProtKB/Swiss-Prot Entry Name | ITPA_BOVIN | ||||||
| PDB IDs | Not Available | ||||||
| GenBank Gene ID | BC112688 | ||||||
| GeneCard ID | ITPA | ||||||
| GenAtlas ID | Not Available | ||||||
| HGNC ID | Not Available | ||||||
| References | |||||||
| General References | Not Available | ||||||