| Identification |
|---|
| BMDB Protein ID
| BMDBP00513 |
| Secondary Accession Numbers
| None |
| Name
| Aurora kinase B |
| Synonyms
|
Not Available
|
| Gene Name
| AURKB |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN and histone H3. A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). AURKB is also required for kinetochore localization of BUB1 and SGO1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| AURKB |
| Gene Sequence
|
>1035 bp
ATGGCCCAGAAGGAGAACGCCTACCCCTGGCCCTATGGCCGGCAGACGGCTCAGCCTGGC
CTGAACACCCTGCCCCAGAGAGTTCTCCGGAAGGAGCCTGTCACTCCATCGGCACTTGTC
CTCATGAGTCGCTCCAATGCCCAGCCCACAGCTGCCCCTGGCCAGAAGGTGGTGGAGAAC
AGCAGTGGAACCCCCAACATCCCAAAGCGTTCCTTCACAATCGATGACTTTGAGATTGGG
CGTCCTCTGGGCAAAGGCAAGTTTGGAAATGTGTACTTGGCTCGGGAGAAGAAAAGCCAT
TTCATCGTGGCGCTCAAAGTCCTCTTCAAGTCTCAGATCGAGAAGGAGGGTGTGGAGCAC
CAGCTGCGTAGAGAGATCGAAATCCAAGCGCATCTGCAACATCCCAACATCTTGCGTCTC
TACAACTATTTCTATGACCGGCGAAGGATCTACTTGATTCTGGAGTATGCCCCCCGGGGG
GAGCTCTACAAGGAGCTGCAGAAGAGCCGAACTTTTGATGAGCAGCGAACAGCCACGATC
ATGGAGGAGCTGGCAGATGCTCTGACATACTGCCATGCGAAGAAGGTGATTCACAGAGAC
ATCAAGCCTGAGAATCTGCTCTTGGGGCTCCGGGGAGAGCTGAAGATTGCTGACTTCGGC
TGGTCGGTGCACGCCCCCTCCCTGAGGAGGAAGACAATGTGCGGCACTCTGGACTACCTG
CCCCCAGAGATGATTGAGGGGCGCACGCACAATGAAAAGGTGGACCTGTGGTGCATCGGT
GTGCTCTGCTACGAGCTGCTGGTGGGAAACCCACCCTTTGAGAGTGCTTCCCACAATGAG
ACGTACCGGCGCATCGTCAAGGTGGACTTAAAGTTCCCTCCTTCTGTGCCCTTGGGAGCC
CAGGACTTCATCTACAAGCTGCTCAAGCATAACCCCTCAGAACGCCTGCCGCTGGCCCAG
GTCTCGGCCCACCCTTGGGTCCGAACCCACTCTCGCAGGGTGCTGCCTCCCTCTGCCCCT
CAGTCTGTCCCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 344 |
| Molecular Weight
| 39442.0 |
| Theoretical pI
| 9.98 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Serine/threonine-protein kinase 12
MAQKENAYPWPYGRQTAQPGLNTLPQRVLRKEPVTPSALVLMSRSNAQPTAAPGQKVVEN
SSGTPNIPKRSFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLQHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSRTFDEQRTATI
MEELADALTYCHAKKVIHRDIKPENLLLGLRGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRTHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPPSVPLGA
QDFIYKLLKHNPSERLPLAQVSAHPWVRTHSRRVLPPSAPQSVP
|
| External Links |
|---|
| GenBank ID Protein
| AAQ16151.1 |
| UniProtKB/Swiss-Prot ID
| Q7YRC6 |
| UniProtKB/Swiss-Prot Entry Name
| AURKB_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY336975 |
| GeneCard ID
| AURKB |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
