Bovine Metabolome Database: Showing Protein DNA-directed RNA polymerase III subunit RPC1 (BMDBP00514)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification
BMDB Protein ID	BMDBP00514
Secondary Accession Numbers	None
Name	DNA-directed RNA polymerase III subunit RPC1
Synonyms	Not Available
Gene Name	POLR3A
Protein Type	Enzyme
Biological Properties
General Function	Transcription
Specific Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
Pathways	Nucleotide Excision Repair
Reactions	Not Available
GO Classification	Not Available
Cellular Location	Not Available
Gene Properties
Chromosome Location	28
Locus	Not Available
SNPs	POLR3A
Gene Sequence	>4173 bp ATGGTGAAGGAGCAGTTCCGGGAGACAGATGTGGCCAAGAAAATAAGCCACATCTGTTTT GGAATGAAGTCAGCCGAGGAGATGCGCCAGCAGGCACACATCCAGGTTGTGAGTAAGAAC CTGTACAGCCAGGACAACAACCACTCCCCACTGCTATACGGGGTGCTTGACCACAGGATG GGTACAAGTGAGAAGGACCGTCCTTGTGAAACCTGTGGGAAGAACTTGGCTGACTGTCTA GGCCACTATGGGTACATTGACTTGGAGCTGCCGTGCTTCCACGTGGGGTACTTCCGAGCA GTTATAGGCATCTTACAGATGATCTGTAAAACCTGCTGCCACATCATGCTGTCCCAGGAG GAGAAGAAGCAGTTTCTGGATTATCTAAAGAGGCCCGGCCTGACCTACCTCCAGAAGCGA GGGCTAAAGAAGAAAATCTCTGACAAGTGCCGGAAAAAGAACACGTGCCATCACTGCGGC GCCTTCAATGGTACTGTCAAGAAATGCGGGTTACTGAAGATAATCCATGAGAAATACAAG ACCAACAAGAAAGTGGTGGATCCCATCGTATCAAGTTTCCTTCAGTCCTTTGAAACCGCC ATAGAGCATAACAAGGAAGTGGAGCCTCTGCTGGGAAAGGCCCAGGAAAACTTGAATCCC TTAGTAGTTTTGAATTTATTTAAACGAATCCCAGCTGAAGATATCCCTCTACTTCTGATG AATCCGGAAGCTGGAAAGCCCTCCGATTTGATTCTCACACGACTCTTAGTGCCCCCTTTG TGCATCAGACCCTCTGTCGTGAGTGATTTGAAGTCTGGCACCAATGAAGACGATCTGACG ATGAAGTTGACAGAAATCATTTTCCTAAATGACGTCATTAAAAAGCATCGGATATCCGGA GCCAAGACCCAGATGATCATGGAAGACTGGGACTTCCTGCAGCTGCAGTGTGCTCTCTAC ATTAACAGCGAGCTCTCAGGCATCCCCCTCAATATGGCACCCAAGAAATGGACCAGAGGG TTTGTCCAGCGCCTGAAGGGAAAGCAGGGTCGATTCAGAGGCAATCTCTCAGGAAAGAGA GTGGATTTTTCTGGTAGAACAGTCATCTCACCTGACCCCAACCTCCGAATTGATGAGGTA GCTGTGCCAGTTCACGTGGCCAAAATTCTAACATTTCCTGAGAAGGTGAACAAAGCAAAC ATCAACTTTTTGAGGAAACTGGTTCGAAATGGCCCTGAAGTTCACCCAGGAGCCAATTTC ATTCAGCAGAGACACACGCAGATGAAAAGGTTTCTGAAATACGGAAACAGAGAAAAGATG GCCCAGGAGCTCAAGTTCGGGGACATTGTGGAGAGGCACCTCATCGATGGAGACGTGGTC CTCTTCAACCGGCAGCCCTCGCTGCACAAACTGAGCATCATGGCGCACCTGGCCAGGGTC AAGCCCCACCGGACTTTCAGATTTAACGAGTGTGTCTGTACACCCTACAATGCGGATTTT GATGGAGATGAAATGAACCTTCATCTTCCTCAAACAGAAGAAGCTAAAGCAGAAGCCCTT GTTCTCATGGGGACTAAAGCAAACCTTGTAACACCGAGAAATGGAGAACCACTAATTGCT GCTATTCAGGATTTTCTGACAGGTGCCTATCTCCTCACTCTTAAGGATACTTTCTTTGAC CGAGCCAAAGCTTGTCAGATCATCGCTTCAATACTGGTGGGCAAGGATGAGAAAATTAAA GTTCGTCTCCCACCCCCTACAATACTCAAGCCTGTCACCCTGTGGACGGGAAAGCAGATC TTCAGTGTCATCCTGAGACCCAGCGATGACAATCCAGTGAGGGCCAACCTCCGAACCAAG GGCAAGCAGTACTGCGGCAGAGGCGAGGACCTCTGTGTCAACGACTCCTACGTCACAATC CAGAACAGCGAGCTGATGAGTGGCAGCATGGACAAAGGAACGCTGGGGTCAGGATCCAAG AACAACATTTTTTACATTTTGCTGCGAGACTGGGGGCAGAATGAAGCTGCCGACGCGATG TCACGGCTTGCCAGGCTGGCTCCCGTCTACTTGTCTAACCGTGGATTCTCAATCGGGATT GGTGACGTCACACCTGGCCAAGGGCTGCTGAAGGCCAAGTATGAGTTGCTGAACGCTGGC TACAAAAAATGCGATGAGTACATCGAAGCCCTGAACACAGGCAAGCTGCAGCAGCAGCCC GGCTGCACCGCCGAGGAGACTCTGGAGGCTTTGATCCTGAAGGAGCTGTCCGTGATCCGT GACCACGCAGGTAGCGCCTGCCTCCGGGAGCTGGATAAGAGCAACAGCCCCCTCACCATG GCTCTGTGTGGTTCCAAAGGTTCCTTCATTAACATATCACAGATGATTGCCTGTGTGGGA CAGCAAGCTATCAGTGGCTCGCGAGTGCCAGATGGCTTTGAAAACAGGTCCCTGCCTCAC TTTGAAAAGCACTCAAAGCTCCCAGCTGCCAAAGGCTTTGTGGCTAATAGCTTTTATTCT GGTTTGACACCAACCGAGTTTTTCTTCCACACGATGGCTGGCCGGGAAGGTCTGGTCGAC ACAGCCGTGAAGACAGCTGAAACAGGATATATGCAGAGAAGGCTCGTCAAGTCCCTGGAA GATCTTTGTTCACAGTATGACCTCACAGTCCGCAGCTCTACGGGCGATATCATCCAGTTC ATTTACGGGGGAGACGGCTTAGATCCTGCAGCCATGGAAGGAAAAGATGAGCCCTTAGAG TTTAAAAGGGTTCTGGACAACATCAAAGCAGTCTTCCCGTGCCGGAGCGAGCCTGCTCTC AGTAAGAACGAGCTGCTCCTGAGCGCCGAGTCCATCATGAAGAAGAACGAGTTTCTCTGC TGCCAGGACAGCTTCCTGCAGGAGATAAAAAAGTTTATCAAGGAGGTTTCTGAGAAGATC AAGAAGACCAGAGATAAATACGGCATCAACGACAACGGCACGACAGAGCCCCGTGTGCTG TACCAGTTGGACCGGATCACCCCCACCCAGATAGAGAAGTTTCTGGAGACGTGTAGGGAC AAGTACATGAGGGCACAGATGGAGCCAGGTTCCGCAGTGGGCGCGCTCTGTGCCCAGAGC ATTGGTGAGCCGGGCACCCAGATGACCCTGAAGACTTTCCACTTTGCGGGCGTGGCCTCC ATGAACATCACCCTGGGCGTGCCCCGCATCAAAGAGATCATCAACGCCTCCAAGGCCATC AGCACTCCCATCATCACAGCACAGCTGGACAAGGATGACGATGCAGATTATGCTCGTCTG GTGAAAGGCAGAATTGAGAAAACCCTCTTGGGAGAGATTTCAGAGTATATCGAAGAAGTG TTTCTTCCTGATGATTGCTTCATTCTCGTCAAGCTCTCCCTAGAACGGATCAGACTTCTG AGGCTGGAAGTGAACGCTGAGACAGTGAGGTACTCCATCTGCATGTCCAAGCTGCGCGTG AAGCCCGGCGACGTGGCCGTGCACGGCGAGGCAGTGGTGTGCGTCACCCCCCGAGAGAAC AGCAAGAGCTCCATGTACTACGTGCTGCAGTTCCTGAAAGAGGATCTCCCCAAGGTGGTG GTGCAGGGCATCCCGGAGGTGTCCCGAGCTGTCATCCACATTGATGAGCAGAGCGGGAAG GAGAAGTACAAGCTCCTGGTGGAGGGGGATAACCTGCGGGCCGTCATGGCCACCCACGGC GTGAAGGGCACCCGGACCACCTCCAACAACACGTACGAGGTGGAGAAAACCCTGGGCATC GAAGCTGCCCGGACAACTATCATCAACGAGATCCAGTATACGATGGTCAACCACGGCATG AGCATCGACCGGCGGCACGTCATGCTGCTCTCCGACCTCATGACCTACAAGGGTGAAGTC CTGGGCATCACCAGGTTTGGCCTGGCCAAGATGAAGGAGAGCGTGCTGATGCTGGCCTCG TTTGAGAAGACGGCCGACCACCTCTTTGACGCTGCCTACTTTGGGCAGAAGGACTCTGTG TGTGGGGTGTCTGAATGCATCATCATGGGGATCCCCATGAACATTGGAACTGGACTCTTC AAGCTGCTCCACAAGGCCAACAGGGACCCCAGCCCTCCCAGGAGGCCCCTCATCTTCGAC ACAAACGAATTCCACATCCCCCTTGTCACCTAG
Protein Properties
Number of Residues	1390
Molecular Weight	155791.0
Theoretical pI	8.7
Pfam Domain Function	Not Available
Signals	None
Transmembrane Regions	3-23 255-275
Protein Sequence	>DNA-directed RNA polymerase III subunit RPC1 MVKEQFRETDVAKKISHICFGMKSAEEMRQQAHIQVVSKNLYSQDNNHSPLLYGVLDHRM GTSEKDRPCETCGKNLADCLGHYGYIDLELPCFHVGYFRAVIGILQMICKTCCHIMLSQE EKKQFLDYLKRPGLTYLQKRGLKKKISDKCRKKNTCHHCGAFNGTVKKCGLLKIIHEKYK TNKKVVDPIVSSFLQSFETAIEHNKEVEPLLGKAQENLNPLVVLNLFKRIPAEDIPLLLM NPEAGKPSDLILTRLLVPPLCIRPSVVSDLKSGTNEDDLTMKLTEIIFLNDVIKKHRISG AKTQMIMEDWDFLQLQCALYINSELSGIPLNMAPKKWTRGFVQRLKGKQGRFRGNLSGKR VDFSGRTVISPDPNLRIDEVAVPVHVAKILTFPEKVNKANINFLRKLVRNGPEVHPGANF IQQRHTQMKRFLKYGNREKMAQELKFGDIVERHLIDGDVVLFNRQPSLHKLSIMAHLARV KPHRTFRFNECVCTPYNADFDGDEMNLHLPQTEEAKAEALVLMGTKANLVTPRNGEPLIA AIQDFLTGAYLLTLKDTFFDRAKACQIIASILVGKDEKIKVRLPPPTILKPVTLWTGKQI FSVILRPSDDNPVRANLRTKGKQYCGRGEDLCVNDSYVTIQNSELMSGSMDKGTLGSGSK NNIFYILLRDWGQNEAADAMSRLARLAPVYLSNRGFSIGIGDVTPGQGLLKAKYELLNAG YKKCDEYIEALNTGKLQQQPGCTAEETLEALILKELSVIRDHAGSACLRELDKSNSPLTM ALCGSKGSFINISQMIACVGQQAISGSRVPDGFENRSLPHFEKHSKLPAAKGFVANSFYS GLTPTEFFFHTMAGREGLVDTAVKTAETGYMQRRLVKSLEDLCSQYDLTVRSSTGDIIQF IYGGDGLDPAAMEGKDEPLEFKRVLDNIKAVFPCRSEPALSKNELLLSAESIMKKNEFLC CQDSFLQEIKKFIKEVSEKIKKTRDKYGINDNGTTEPRVLYQLDRITPTQIEKFLETCRD KYMRAQMEPGSAVGALCAQSIGEPGTQMTLKTFHFAGVASMNITLGVPRIKEIINASKAI STPIITAQLDKDDDADYARLVKGRIEKTLLGEISEYIEEVFLPDDCFILVKLSLERIRLL RLEVNAETVRYSICMSKLRVKPGDVAVHGEAVVCVTPRENSKSSMYYVLQFLKEDLPKVV VQGIPEVSRAVIHIDEQSGKEKYKLLVEGDNLRAVMATHGVKGTRTTSNNTYEVEKTLGI EAARTTIINEIQYTMVNHGMSIDRRHVMLLSDLMTYKGEVLGITRFGLAKMKESVLMLAS FEKTADHLFDAAYFGQKDSVCGVSECIIMGIPMNIGTGLFKLLHKANRDPSPPRRPLIFD TNEFHIPLVT
External Links
GenBank ID Protein	AAI34423.1
UniProtKB/Swiss-Prot ID	A4IF62
UniProtKB/Swiss-Prot Entry Name	RPC1_BOVIN
PDB IDs	Not Available
GenBank Gene ID	BC134422
GeneCard ID	POLR3A
GenAtlas ID	Not Available
HGNC ID	Not Available
References
General References	Not Available