| Identification |
|---|
| BMDB Protein ID
| BMDBP00517 |
| Secondary Accession Numbers
| None |
| Name
| ATP-dependent Clp protease proteolytic subunit, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| CLPP |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Posttranslational modification, protein turnover, chaperones |
| Specific Function
| Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Cleaves PINK1 in the mitochondrion. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| CLPP |
| Gene Sequence
|
>819 bp
ATGTGGCCCAAAATATTGCTTAGGGGGGGCCGGGTGGCGGCCGGCTTGTGCCCAGCACTG
GGGCCTCGCCTCGCCGCCCGCTTTCCCCCGCAGCGGACGCCCGAGAATCGCCTGGCCCCG
CAGCGGAACCTGCACGCGACGGCGGCCCGGGCTCTCCCGCTCATTCCCATCGTGGTGGAG
CAGACGGGTCGCGGTGAGCGCGCCTATGACATCTACTCGCGGCTGCTTCGGGAGCGTATT
GTGTGCGTCATGGGCCCTATCGATGACAGTGTCGCCAGCCTGGTCATCGCGCAGCTGCTG
TTCCTGCAGTCGGAAAGCAACAAGAAGCCCATCCACATGTATATCAACAGCCCCGGTGGC
GTGGTGACCTCGGGCCTGGCCATCTACGACACGATGCAATACATCCTGAACCCCATCTGC
ACGTGGTGTGTGGGCCAGGCAGCCAGCATGGGCTCCCTGCTTCTGGCTGCTGGCACCCCA
GGCATGCGCCACTCACTCCCCAACTCCCGCATCATGATCCACCAGCCCTCTGGGGGTGCC
CGGGGCCAAGCCACAGACATCGCCATCCAGGCAGAGGAGATCATGAAGCTCAAGAAGCAG
CTCTACAGCATCTACGCCAAGCACACCAAACAGAGCCTGCAGGTGATCGAGTCAGCCATG
GAGAGGGACCGCTACATGAGCCCCATGGAGGCCCAGGAGTTCGGCATCTTGGACAAGGTT
CTGGTCCACCCCCCACAGGATGGGGAGGATGAGCCGGAGCTGGTACAGAAGGAGCCGGGG
GAGCCAACAGCAGTAGAACCCGCCCCAGCCAGCGCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 272 |
| Molecular Weight
| 29704.0 |
| Theoretical pI
| 8.32 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial
MWPKILLRGGRVAAGLCPALGPRLAARFPPQRTPENRLAPQRNLHATAARALPLIPIVVE
QTGRGERAYDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNKKPIHMYINSPGG
VVTSGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAGTPGMRHSLPNSRIMIHQPSGGA
RGQATDIAIQAEEIMKLKKQLYSIYAKHTKQSLQVIESAMERDRYMSPMEAQEFGILDKV
LVHPPQDGEDEPELVQKEPGEPTAVEPAPASA
|
| External Links |
|---|
| GenBank ID Protein
| AAI12881.1 |
| UniProtKB/Swiss-Prot ID
| Q2KHU4 |
| UniProtKB/Swiss-Prot Entry Name
| CLPP_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC112880 |
| GeneCard ID
| CLPP |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
