| Identification |
|---|
| BMDB Protein ID
| BMDBP00523 |
| Secondary Accession Numbers
| None |
| Name
| ATP-dependent 6-phosphofructokinase, muscle type |
| Synonyms
|
Not Available
|
| Gene Name
| PFKM |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Carbohydrate transport and metabolism |
| Specific Function
| Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. |
| Pathways
|
- Carbohydrate degradation
- D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4
- Glycolysis
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| PFKM |
| Gene Sequence
|
>2340 bp
ATGACCCATGAGCACCATGCAGCCAAAACCCTGGGAATCGGCAAAGCCATCGCCGTGTTA
ACCTCTGGTGGCGATGCCCAAGGTATGAATGCTGCTGTCAGGGCTGTGGTTCGTGTTGGC
ATCTATACTGGTGCCCGTGTCTTCTTTGTCCATGAGGGTTATCAAGGCCTGGTAGATGGT
GGAGATAACATCCGGGAAGCCACATGGGAGAGTGTCTCGATGATGCTTCAGCTGGGAGGC
ACGGTGATTGGAAGCGCCCGGTGCAAGGACTTTCGGGAACGGGAAGGCCGGCTCCGAGCT
GCCCACAACCTGGTGAAACGTGGGATCACCAACCTGTGTGTCATTGGGGGAGACGGCAGC
CTGACTGGGGCCGACACCTTCCGCTCTGAGTGGAGTGACTTGTTGAGTGACCTCCAGAAA
TCAGGCAAGATTACAGCAGAGGAGGCTACCAAGTCCAGCTACCTGAACATCGTGGGGCTG
GTTGGCTCAATTGACAATGACTTCTGTGGCACTGATATGACCATTGGCACCGACTCTGCC
CTGCACCGGATCATAGAGATTGTAGATGCCATCACTACTACCGCTCAGAGCCACCAGAGG
ACCTTTGTGTTGGAGGTGATGGGCCGGCACTGTGGATACCTGGCCCTTGTCACTTCCCTC
TCCTGTGGGGCCGACTGGGTCTTTATTCCCGAGTGTCCACCAGATGACGACTGGGAGGAA
CACCTTTGTCGCCGGCTCAGCGAGACAAGGAACCGTGGTTCTCGTCTCAACATCATCATC
GTAGCTGAGGGTGCGATTGACAAGAATGGGAAACCAATCACCTCTGAAGACATCAAAAAC
CTGGTGGTTAAGCGTCTGGGATATGACACCCGAGTCACCGTCTTGGGGCACGTGCAGCGG
GGTGGGACACCGTCGGCCTTTGACAGAATCCTGGGCAGCAGGATGGGTGTGGAAGCAGTA
ATGGCACTTTTGGAGGGGACCCCGGACACCCCAGCCTGTGTGGTGAGCCTCTCTGGTAAC
CAGGCTGTGCGCCTGCCCCTCATGGAGTGTGTCCAGGTGACCAAGGACGTGACCAGGGCC
ATGGATGAAAGGAGATTCGATGAGGCCTTGAAGCTGAGGGGCCGGAGCTTCATGAACAAC
TGGGAGGTATACAAGCTTCTGGCTCACGTCAGACCCCCAAAGTCTAAGAGTGGCTCCCAC
ACGGTGGCCGTGATGAACGTGGGAGCGCCGGCCGCAGGCATGAACGCAGCCGTTCGCTCC
ACTGTGAGAATCGGCCTCATCCAGGGCAACCGAATGCTGGTGGTGCACGATGGCTTCGAG
GGCCTGGCCAAGGGTCAGATCGAGGAAGCTGGATGGAGCTACGTCGGGGGCTGGACTGGC
CAAGGTGGTTCTAAACTTGGGACTAAAAGGACTCTACCCAAGAAGAGCTTTGAACAGATC
AGTGCCAACATCACGAAGTTTAATATTCAGGGCCTTGTCATTATCGGGGGCTTTGAGGCT
TACACGGGGGGCCTGGAGCTGATGGAAGGCAGGAAGCAGTATGATGAGCTCTGCATCCCC
TTCGTGGTCATCCCTGCCACGGTCTCCAACAATGTGCCCGGCTCGGACTTCAGCGTGGGG
GCTGACACTGCCCTCAACACCATCTGCATGACGTGTGACCGCATCAAGCAGTCAGCGGCA
GGCACCAAGCGCCGTGTGTTTATCATTGAAACGATGGGCGGCTACTGTGGCTACCTGGCC
ACCATGGCAGGCCTGGCAGCTGGGGCTGATGCTGCGTATATTTTTGAGGACCCCTTCACC
ATTCGAGACCTGCAGGTGAATGTGGAGCATCTGGTGCAGAAGATGAAAACGACTGTGAAG
AGGGGCCTGGTGTTAAGGAACGAGAAGTGCAATGAGAACTACACCACTGACTTCATCTTC
AACTTGTACTCTGAGGAGGGGAAGGGCATCTTCGACAGCAGGAAGAACGTGCTGGGCCAC
ATGCAGCAGGGTGGGAGCCCAACTCCATTCGACAGGAATTTTGCCACTAAGATGGGTGCA
AAGGCTATGAACTGGATGTCAGGGAAAATCAAAGAGAGTTACCGTAATGGGCGGATCTTT
GCCAATTCCCCAGACTCGGGCTGTGTTCTGGGGATGCGTAAGAGGGCCCTGGTCTTCCAA
CCAGTGACTGAGTTGAAGGAACAGACGGATTTTGAGCACCGCATCCCCAAGGAGCAGTGG
TGGCTGAAGCTGAGGCCCATCCTCAAGATCCTCGCCAAGTACGAGATTGACTTGGATACC
TCAGAGCACGCCCACCTGGAGCACATCTCTCGGAAGCGGTCCGGAGAAGCTAACGTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 779 |
| Molecular Weight
| 85294.0 |
| Theoretical pI
| 8.37 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>6-phosphofructokinase, muscle type
MTHEHHAAKTLGIGKAIAVLTSGGDAQGMNAAVRAVVRVGIYTGARVFFVHEGYQGLVDG
GDNIREATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAHNLVKRGITNLCVIGGDGS
LTGADTFRSEWSDLLSDLQKSGKITAEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDSA
LHRIIEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEE
HLCRRLSETRNRGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQR
GGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSGNQAVRLPLMECVQVTKDVTRA
MDERRFDEALKLRGRSFMNNWEVYKLLAHVRPPKSKSGSHTVAVMNVGAPAAGMNAAVRS
TVRIGLIQGNRMLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQI
SANITKFNIQGLVIIGGFEAYTGGLELMEGRKQYDELCIPFVVIPATVSNNVPGSDFSVG
ADTALNTICMTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEDPFT
IRDLQVNVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGH
MQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANSPDSGCVLGMRKRALVFQ
PVTELKEQTDFEHRIPKEQWWLKLRPILKILAKYEIDLDTSEHAHLEHISRKRSGEANV
|
| External Links |
|---|
| GenBank ID Protein
| AAI22656.1 |
| UniProtKB/Swiss-Prot ID
| Q0IIG5 |
| UniProtKB/Swiss-Prot Entry Name
| PFKAM_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC122655 |
| GeneCard ID
| PFKM |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
