Showing Protein Protein phosphatase 1A (BMDBP00524)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00524 |
| Secondary Accession Numbers | None |
| Name | Protein phosphatase 1A |
| Synonyms | Not Available |
| Gene Name | PPM1A |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Signal transduction mechanisms |
| Specific Function | Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling (By similarity). Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 10 |
| Locus | Not Available |
| SNPs | PPM1A |
| Gene Sequence |
>1149 bp ATGGGAGCATTTTTAGACAAACCAAAGATGGAAAAACATAATGCCCAGGGGCAGGGTAAT GGGTTGCGATATGGGCTAAGCAGCATGCAAGGCTGGCGAGTTGAAATGGAGGATGCACAT ACTGCTGTGATCGGTCTGCCAAGTGGACTTGAAACATGGTCATTCTTTGCTGTGTATGAT GGGCATGCTGGTTCTCAGGTTGCCAAATACTGCTGTGAGCATTTGTTAGATCACATCACC AATAACCAGGATTTTAAAGGGTCTGCAGGAGCACCTTCTGTGGAAAATGTAAAGAATGGA ATCAGAACAGGCTTCCTGGAGATTGATGAACATATGAGAGTTATGTCAGAGAAGAAACAT GGTGCTGATAGGAGTGGGTCAACAGCTGTGGGTGTCTTAATTTCTCCTCAACACACGTAT TTCATTAACTGTGGAGACTCAAGAGGTTTACTTTGTAGGAACAGGAAAGTTTACTTCTTC ACACAAGATCACAAACCAAGTAATCCGCTGGAAAAAGAACGAATTCAGAATGCAGGTGGT TCTGTAATGATTCAGCGTGTGAATGGCTCTCTGGCTGTGTCGAGGGCCCTTGGGGACTTT GATTACAAATGTGTCCATGGAAAAGGTCCTACAGAGCAGCTTGTTTCACCAGAGCCTGAA GTCCATGATATTGAAAGATCTGAAGAAGATGATCAATTCATTATTCTTGCATGTGATGGT ATTTGGGATGTCATGGGAAATGAAGAGCTCTGTGATTTTGTAAGATCCAGACTTGAAGTC ACTGATGACCTTGAGAAAGTTTGCAATGAAGTAGTCGACACCTGTTTGTATAAGGGAAGT CGAGACAACATGAGTGTGATATTGATCTGTTTTCCAAATGCACCCAAAGTATCGCCAGAA GCAGTGAAGAAGGAGGAAGAGTTGGACAAATACCTGGAAAGCAGAGTAGAAGAAATCATA AAGAAGCAGGGGGAAGGCGTCCCTGACTTAGTCCATGTGATGCGCACATTAGCGAGTGAG AACATACCCAGCCTCCCACCAGGGGGTGAACTGGCAAGCAAGCGGAATGTAATTGAAGCC GTTTACAATAGACTGAATCCATACAAAAATGATGACACCGACTCTACATCAACTGATGAT ATGTGGTAA |
| Protein Properties | |
| Number of Residues | 382 |
| Molecular Weight | 42530.0 |
| Theoretical pI | 4.89 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Protein phosphatase 1A MGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLETWSFFAVYD GHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKH GADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVYFFTQDHKPSNPLEKERIQNAGG SVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDG IWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPE AVKKEEELDKYLESRVEEIIKKQGEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEA VYNRLNPYKNDDTDSTSTDDMW |
| External Links | |
| GenBank ID Protein | CAA06554.1 |
| UniProtKB/Swiss-Prot ID | O62829 |
| UniProtKB/Swiss-Prot Entry Name | PPM1A_BOVIN |
| PDB IDs | |
| GenBank Gene ID | AJ005457 |
| GeneCard ID | PPM1A |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |