Showing Protein Diacylglycerol O-acyltransferase 2 (BMDBP00535)
| Identification | |||
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| BMDB Protein ID | BMDBP00535 | ||
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| Name | Diacylglycerol O-acyltransferase 2 | ||
| Synonyms | Not Available | ||
| Gene Name | DGAT2 | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Involved in diacylglycerol O-acyltransferase activity | ||
| Specific Function | Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides. Functions also as an acyl-CoA retinol acyltransferase (ARAT) (By similarity). | ||
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| Reactions |
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 15 | ||
| Locus | Not Available | ||
| SNPs | DGAT2 | ||
| Gene Sequence |
>1086 bp ATGAAGACCCTCATAGCCGCCTACTCCGGGGTCCTGCGAGGCACTGGCTCCAGCATCCTC TCTGCCCTCCAGGACCTGTTTTCTGTCACTTGGCTCAATAGGGCCAAGGTAGAGAAGCAG CTCCAAGTCATCTCGGTGCTACAATGGGTCCTGTCTTTCCTCGTGCTGGGAGTGGCCTGC AGCGTCATCCTCATGTACACATTCTGCACCGATTGCTGGCTCATTGCCGTGCTCTACTTC ACCTGGCTGGTGTTTGACTGGAACACACCCAAGAAAGGTGGCAGGAGGTCACAGTGGGTC CGAAACTGGGCTGTGTGGCGCTACTTTCGAGACTACTTTCCCATTCAGCTGGTGAAGACA CACAACTTACTGACCAGCAGGAACTACATCTTTGGGTACCATCCCCATGGCATCATGGGC CTGGGTGCCTTCTGCAACTTCAGCACAGAGGCCACAGAAGTAAGCAAGAAGTTCCCTGGC ATAAGGCCCTACCTGGCCACGCTGGCCGGCAACTTCCGGATGCCAGTGCTGCGGGAGTAC CTGATGTCTGGAGGCATCTGCCCAGTGAACCGGGACACCATAGACTACTTGCTTTCAAAG AATGGGAGTGGCAATGCCATCATCATCGTGGTGGGGGGCGCGGCTGAATCCCTGAGCTCC ATGCCCGGCAAGAATGCAGTCACCCTGCGCAATCGCAAGGGCTTTGTGAAACTGGCCCTG CGCCATGGAGCCGACCTGGTTCCCACCTACTCCTTTGGGGAGAATGAGGTGTACAAGCAG GTGATCTTTGAGGAGGGCTCCTGGGGCCGGTGGGTGCAGAAGAAGTTCCAGAAGTACATT GGCTTTGCCCCATGCATCTTCCATGGTCGAGGCCTCTTCTCCTCTGACACCTGGGGGCTG GTGCCCTACTCCAAGCCCATCACCACTGTCGTGGGCGAGCCCATTACCATCCCCAGGCTG GAGCGCCCGACGCAGCAGGACATCGACCTGTACCACGCCATGTACGTGCAAGCCCTGGTG AAGCTCTTCGACCAGCATAAGACCAAGTTCGGCCTCCCGGAGACCGAGGTCCTGGAGGTG AACTGA |
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| Protein Properties | |||
| Number of Residues | 361 | ||
| Molecular Weight | 40896.0 | ||
| Theoretical pI | 9.81 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>Diacylglycerol O-acyltransferase 2 MKTLIAAYSGVLRGTGSSILSALQDLFSVTWLNRAKVEKQLQVISVLQWVLSFLVLGVAC SVILMYTFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKT HNLLTSRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREY LMSGGICPVNRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLAL RHGADLVPTYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGL VPYSKPITTVVGEPITIPRLERPTQQDIDLYHAMYVQALVKLFDQHKTKFGLPETEVLEV N |
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| External Links | |||
| GenBank ID Protein | CAD58592.1 | ||
| UniProtKB/Swiss-Prot ID | Q70VZ8 | ||
| UniProtKB/Swiss-Prot Entry Name | DGAT2_BOVIN | ||
| PDB IDs | Not Available | ||
| GenBank Gene ID | AJ519787 | ||
| GeneCard ID | DGAT2 | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||