| Identification |
|---|
| BMDB Protein ID
| BMDBP00535 |
| Secondary Accession Numbers
| |
| Name
| Diacylglycerol O-acyltransferase 2 |
| Synonyms
|
Not Available
|
| Gene Name
| DGAT2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in diacylglycerol O-acyltransferase activity |
| Specific Function
| Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides. Functions also as an acyl-CoA retinol acyltransferase (ARAT) (By similarity). |
| Pathways
|
- Glycerolipid Metabolism
- Triacylglycerol biosynthesis
|
| Reactions
|
| 11-cis-Retinol + Acetyl-CoA → Retinyl palmitate + Coenzyme A |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| Not Available |
| SNPs
| DGAT2 |
| Gene Sequence
|
>1086 bp
ATGAAGACCCTCATAGCCGCCTACTCCGGGGTCCTGCGAGGCACTGGCTCCAGCATCCTC
TCTGCCCTCCAGGACCTGTTTTCTGTCACTTGGCTCAATAGGGCCAAGGTAGAGAAGCAG
CTCCAAGTCATCTCGGTGCTACAATGGGTCCTGTCTTTCCTCGTGCTGGGAGTGGCCTGC
AGCGTCATCCTCATGTACACATTCTGCACCGATTGCTGGCTCATTGCCGTGCTCTACTTC
ACCTGGCTGGTGTTTGACTGGAACACACCCAAGAAAGGTGGCAGGAGGTCACAGTGGGTC
CGAAACTGGGCTGTGTGGCGCTACTTTCGAGACTACTTTCCCATTCAGCTGGTGAAGACA
CACAACTTACTGACCAGCAGGAACTACATCTTTGGGTACCATCCCCATGGCATCATGGGC
CTGGGTGCCTTCTGCAACTTCAGCACAGAGGCCACAGAAGTAAGCAAGAAGTTCCCTGGC
ATAAGGCCCTACCTGGCCACGCTGGCCGGCAACTTCCGGATGCCAGTGCTGCGGGAGTAC
CTGATGTCTGGAGGCATCTGCCCAGTGAACCGGGACACCATAGACTACTTGCTTTCAAAG
AATGGGAGTGGCAATGCCATCATCATCGTGGTGGGGGGCGCGGCTGAATCCCTGAGCTCC
ATGCCCGGCAAGAATGCAGTCACCCTGCGCAATCGCAAGGGCTTTGTGAAACTGGCCCTG
CGCCATGGAGCCGACCTGGTTCCCACCTACTCCTTTGGGGAGAATGAGGTGTACAAGCAG
GTGATCTTTGAGGAGGGCTCCTGGGGCCGGTGGGTGCAGAAGAAGTTCCAGAAGTACATT
GGCTTTGCCCCATGCATCTTCCATGGTCGAGGCCTCTTCTCCTCTGACACCTGGGGGCTG
GTGCCCTACTCCAAGCCCATCACCACTGTCGTGGGCGAGCCCATTACCATCCCCAGGCTG
GAGCGCCCGACGCAGCAGGACATCGACCTGTACCACGCCATGTACGTGCAAGCCCTGGTG
AAGCTCTTCGACCAGCATAAGACCAAGTTCGGCCTCCCGGAGACCGAGGTCCTGGAGGTG
AACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 361 |
| Molecular Weight
| 40896.0 |
| Theoretical pI
| 9.81 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Diacylglycerol O-acyltransferase 2
MKTLIAAYSGVLRGTGSSILSALQDLFSVTWLNRAKVEKQLQVISVLQWVLSFLVLGVAC
SVILMYTFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKT
HNLLTSRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREY
LMSGGICPVNRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLAL
RHGADLVPTYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGL
VPYSKPITTVVGEPITIPRLERPTQQDIDLYHAMYVQALVKLFDQHKTKFGLPETEVLEV
N
|
| External Links |
|---|
| GenBank ID Protein
| CAD58592.1 |
| UniProtKB/Swiss-Prot ID
| Q70VZ8 |
| UniProtKB/Swiss-Prot Entry Name
| DGAT2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ519787 |
| GeneCard ID
| DGAT2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
