Showing Protein Phospholipid hydroperoxide glutathione peroxidase (BMDBP00541)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00541 |
| Secondary Accession Numbers | None |
| Name | Phospholipid hydroperoxide glutathione peroxidase |
| Synonyms | Not Available |
| Gene Name | GPX4 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Posttranslational modification, protein turnover, chaperones |
| Specific Function | Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation. Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species. The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis. The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures. May be required to protect cells from the toxicity of ingested lipid hydroperoxides. Required for normal sperm development and male fertility. Essential for maturation and survival of photoreceptor cells. Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 7 |
| Locus | Not Available |
| SNPs | GPX4 |
| Gene Sequence |
>594 bp ATGAGCTTTAGCCGTCTGTACCGCCTGCTCAAGCCAGCGCTACTCTGCGGGGCTCTGGCT GCGCCGGGCCTGGCCAGCACCATGTGCGCGTCCCGCGACGACTGGCGCTGTGCTCGCTCC ATGCACGAATTTTCAGCCAAGGACATCGACGGGCGCATGGTTAACCTGGACAAGTACCGG GGCCACGTGTGCATCGTCACCAATGTGGCCTCGCAATGAGGCAAGACTGACGTAAACTAC ACTCAGCTGGTCGACCTGCACGCCCGATACGCCGAGTGTGGTTTACGGATCCTGGCCTTC CCTTGCAACCAGTTTGGGAGGCAGGAGCCAGGGAGTAATGCAGAGATCAAAGAGTTCGCC GCTGGCTATAACGTCAAATTCGATTTGTTCAGCAAGATCTGTGTAAATGGGGACGACGCC CACCCTCTGTGGAAATGGATGAAAGTCCAGCCCAAGGGGAGAGGCATGCTGGGAAACGCC ATCAAATGGAACTTCACCAAGTTCCTCATTGACAAGAACGGCTGTGTGGTGAAGCGGTAT GGTCCCATGGAAGAGCCCCTGGTGATAGAGAAGGACCTGCCGTGCTACCTCTAG |
| Protein Properties | |
| Number of Residues | 197 |
| Molecular Weight | 22240.0 |
| Theoretical pI | 8.79 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Phospholipid hydroperoxide glutathione peroxidase, mitochondrial MSFSRLYRLLKPALLCGALAAPGLASTMCASRDDWRCARSMHEFSAKDIDGRMVNLDKYR GHVCIVTNVASQUGKTDVNYTQLVDLHARYAECGLRILAFPCNQFGRQEPGSNAEIKEFA AGYNVKFDLFSKICVNGDDAHPLWKWMKVQPKGRGMLGNAIKWNFTKFLIDKNGCVVKRY GPMEEPLVIEKDLPCYL |
| External Links | |
| GenBank ID Protein | BAA86034.1 |
| UniProtKB/Swiss-Prot ID | Q9N2J2 |
| UniProtKB/Swiss-Prot Entry Name | GPX4_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | AB017534 |
| GeneCard ID | GPX4 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |