Showing Protein Type II iodothyronine deiodinase (BMDBP00546)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00546 |
| Secondary Accession Numbers | None |
| Name | Type II iodothyronine deiodinase |
| Synonyms | Not Available |
| Gene Name | DIO2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in selenium binding |
| Specific Function | Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 10 |
| Locus | Not Available |
| SNPs | DIO2 |
| Gene Sequence |
>810 bp ATGGGCATCCTCAGCGTAGACTTGCTGATCACACTGCAGATTCTGCCAGTTTTTTTCTCC AACTGCCTCTTCCTGGCGCTCTATGACTCGGTCATTCTCCTCAAGCACGTGGTGCTGCTG CTGAGCCGCTCCAAGTCCACTCGCGGGCAGTGGAGGCGCATGCTGACCTCAGAAGGAATG CGCTGCATCTGGAAAAGCTTCCTCCTCGACGCCTACAAACAGGTGAAACTGGGTGAAGAT GCCCCCAATTCCAGCGTGGTGCATGTCTCCAGTCCGGAAGGAGGTGACACCAGTGGAAAT GGTGCCCAGGAGAAAACAGTGGATGGAACTGAATGCCACCTTCTGGACTTTGCCAGCCCT GAGCGCCCACTGGTGGTCAACTTCGGCTCGGCCACTTGACCTCCTTTCACTAACCAGCTG CCAGCCTTCAGCAAACTGGTGGAAGAGTTCTCATCCGTGGCTGACTTCCTGTTGGTCTAC ATTGATGAGGCTCATCCTTCAGATGGTTGGGCAGTGCCTGGGGATTCTTCTTTGTTTTTC GAGGTGAAGAAGCACCGGAACCAGGAAGACCGATGCGCAGCAGCCCACCAGCTCCTGGAG CGTTTCTCCTTGCCGCCCCAGTGCCGAGTTGTGGCTGACCGCATGGACAATAATGCCAAC GTTGCTTATGGGGTAGCCTTTGAACGTGTGTGCATCGTGCAGAGACAGAAAATTGCTTAT CTGGGAGGAAAGGGCCCCTTCTTTTACAACCTGCAAGAAGTCCGGCGTTGGCTGGAGAAG AATTTCAGCAAGAGATGAAAGCTAGATTAG |
| Protein Properties | |
| Number of Residues | 269 |
| Molecular Weight | 30303.0 |
| Theoretical pI | 7.47 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
|
| Protein Sequence |
>Type II iodothyronine deiodinase MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGQWRRMLTSEGM RCIWKSFLLDAYKQVKLGEDAPNSSVVHVSSPEGGDTSGNGAQEKTVDGTECHLLDFASP ERPLVVNFGSATUPPFTNQLPAFSKLVEEFSSVADFLLVYIDEAHPSDGWAVPGDSSLFF EVKKHRNQEDRCAAAHQLLERFSLPPQCRVVADRMDNNANVAYGVAFERVCIVQRQKIAY LGGKGPFFYNLQEVRRWLEKNFSKRUKLD |
| External Links | |
| GenBank ID Protein | AAW51123.1 |
| UniProtKB/Swiss-Prot ID | Q5I3B2 |
| UniProtKB/Swiss-Prot Entry Name | IOD2_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | AY858551 |
| GeneCard ID | DIO2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |