Showing Protein Methionine-R-sulfoxide reductase B1 (BMDBP00547)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00547 |
| Secondary Accession Numbers | None |
| Name | Methionine-R-sulfoxide reductase B1 |
| Synonyms | Not Available |
| Gene Name | MSRB1 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Posttranslational modification, protein turnover, chaperones |
| Specific Function | Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 25 |
| Locus | Not Available |
| SNPs | MSRB1 |
| Gene Sequence |
>285 bp ATGTCGTTCTGCAGCTTCTTCGGAGGCGAGATTTTCCAGAACCACTTTGAGCCGGGTATC TACGTGTGTGCCAAGTGTGGCTATGAGCTCTTCTCCAGCCGCTCCAAGTACGCACACTCA TCCCCATGGCCGGCGTTCACTGAGACCATCCATGCTGACAGTGTGGCCAAGCGGCCAGAG CACAATCGGCCTGGAGCCATAAAGGTATCCTGTGGCAGGTGTGGCAACGGGCTGGGCCAT GAGTTCCTGAACGATGGCCCCAAGCGCGGACAGTCCCGCTTCTGA |
| Protein Properties | |
| Number of Residues | 116 |
| Molecular Weight | 12833.0 |
| Theoretical pI | 8.5 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Methionine-R-sulfoxide reductase B1 MSFCSFFGGEIFQNHFEPGIYVCAKCGYELFSSRSKYAHSSPWPAFTETIHADSVAKRPE HNRPGAIKVSCGRCGNGLGHEFLNDGPKRGQSRFUIFSSSLKFIPKAEETSASQGQ |
| External Links | |
| GenBank ID Protein | AAI05189.1 |
| UniProtKB/Swiss-Prot ID | Q3MHL9 |
| UniProtKB/Swiss-Prot Entry Name | MSRB1_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC105188 |
| GeneCard ID | MSRB1 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |