| Identification |
|---|
| BMDB Protein ID
| BMDBP00548 |
| Secondary Accession Numbers
| None |
| Name
| Thyroxine 5-deiodinase |
| Synonyms
|
Not Available
|
| Gene Name
| DIO3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in selenium binding |
| Specific Function
| Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 21 |
| Locus
| Not Available |
| SNPs
| DIO3 |
| Gene Sequence
|
>837 bp
ATGCTGCGCTCCCTGCTGCTTCACTCCCTGAGGCTCTGCTCCCAGACGGCCTCGTGCCTC
GTGCTCTTCCCGCGCTTCCTGGGCACGGCCTTCATGCTCTGGCTGCTAGACTTCCTGTGC
ATCCGTAAGCATTTACTGGGCCGTCGACGCCGGGGTCAGCCGGAAATCGAAGTGGAGCTC
AACAGCGATGGCGAGGAGGTGCCCCCCGACGACCCGCCTGTCTGCGTGTCCGACGACAAC
CGCCTGTGCACCTTGGCGTCGCTGAGGGCCGTCTGGCACGGCCAGAAGTTGGATTTCTTC
AAGCAGGCGCATGAAGGCGGGCCGGCGCCCAACTCTGAGGTGGTCCTGCCCGACGGCTTC
CAGAACCAGCACATCCTCGACTACGCCCGAGGAAACCGTCCGCTGGTGCTCAACTTCGGC
AGCTGCACCTGACCACCGTTCATGGCGCGCATGAGCGCCTTCCAGCGCCTGGTCACCAAG
TATCAGCGCGACGTCGACTTCCTCATCATCTACATCGAGGAAGCTCACCCTTCCGACGGC
TGGGTCACCACAGACTCTCCCTACAGCATCCCGCAGCACCGAAGCCTGGAGGACCGGGTC
AGCGCCGCGCGCGTACTGCAGCAAGGGGCTCCAGAATGCGCTCTCGTGCTCGACACGATG
ACCAACTCCAGCAGCTCGGCCTACGGTGCCTACTTCGAGCGCCTCTACATCATCCAGAGT
GGCACCATTATGTACCAGGGCGGCCGCGGCCCCGACGGCTACCAGGTCTCCGAGGTGCGC
ACCTGGCTGGAGCGCTATGATGAGCAGCTGCACGGCCCACAGCCCCGTCGAGTGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 301 |
| Molecular Weight
| 33888.0 |
| Theoretical pI
| 6.5 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Type III iodothyronine deiodinase
MLRSLLLHSLRLCSQTASCLVLFPRFLGTAFMLWLLDFLCIRKHLLGRRRRGQPEIEVEL
NSDGEEVPPDDPPVCVSDDNRLCTLASLRAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGF
QNQHILDYARGNRPLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG
WVTTDSPYSIPQHRSLEDRVSAARVLQQGAPECALVLDTMTNSSSSAYGAYFERLYIIQS
GTIMYQGGRGPDGYQVSEVRTWLERYDEQLHGPQPRRV
|
| External Links |
|---|
| GenBank ID Protein
| AAW51124.1 |
| UniProtKB/Swiss-Prot ID
| Q5I3B1 |
| UniProtKB/Swiss-Prot Entry Name
| IOD3_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AAFC03027682 |
| GeneCard ID
| DIO3 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
