Showing Protein Thyroxine 5-deiodinase (BMDBP00548)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00548 |
| Secondary Accession Numbers | None |
| Name | Thyroxine 5-deiodinase |
| Synonyms | Not Available |
| Gene Name | DIO3 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in selenium binding |
| Specific Function | Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 21 |
| Locus | Not Available |
| SNPs | DIO3 |
| Gene Sequence |
>837 bp ATGCTGCGCTCCCTGCTGCTTCACTCCCTGAGGCTCTGCTCCCAGACGGCCTCGTGCCTC GTGCTCTTCCCGCGCTTCCTGGGCACGGCCTTCATGCTCTGGCTGCTAGACTTCCTGTGC ATCCGTAAGCATTTACTGGGCCGTCGACGCCGGGGTCAGCCGGAAATCGAAGTGGAGCTC AACAGCGATGGCGAGGAGGTGCCCCCCGACGACCCGCCTGTCTGCGTGTCCGACGACAAC CGCCTGTGCACCTTGGCGTCGCTGAGGGCCGTCTGGCACGGCCAGAAGTTGGATTTCTTC AAGCAGGCGCATGAAGGCGGGCCGGCGCCCAACTCTGAGGTGGTCCTGCCCGACGGCTTC CAGAACCAGCACATCCTCGACTACGCCCGAGGAAACCGTCCGCTGGTGCTCAACTTCGGC AGCTGCACCTGACCACCGTTCATGGCGCGCATGAGCGCCTTCCAGCGCCTGGTCACCAAG TATCAGCGCGACGTCGACTTCCTCATCATCTACATCGAGGAAGCTCACCCTTCCGACGGC TGGGTCACCACAGACTCTCCCTACAGCATCCCGCAGCACCGAAGCCTGGAGGACCGGGTC AGCGCCGCGCGCGTACTGCAGCAAGGGGCTCCAGAATGCGCTCTCGTGCTCGACACGATG ACCAACTCCAGCAGCTCGGCCTACGGTGCCTACTTCGAGCGCCTCTACATCATCCAGAGT GGCACCATTATGTACCAGGGCGGCCGCGGCCCCGACGGCTACCAGGTCTCCGAGGTGCGC ACCTGGCTGGAGCGCTATGATGAGCAGCTGCACGGCCCACAGCCCCGTCGAGTGTAA |
| Protein Properties | |
| Number of Residues | 301 |
| Molecular Weight | 33888.0 |
| Theoretical pI | 6.5 |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>Type III iodothyronine deiodinase MLRSLLLHSLRLCSQTASCLVLFPRFLGTAFMLWLLDFLCIRKHLLGRRRRGQPEIEVEL NSDGEEVPPDDPPVCVSDDNRLCTLASLRAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGF QNQHILDYARGNRPLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG WVTTDSPYSIPQHRSLEDRVSAARVLQQGAPECALVLDTMTNSSSSAYGAYFERLYIIQS GTIMYQGGRGPDGYQVSEVRTWLERYDEQLHGPQPRRV |
| External Links | |
| GenBank ID Protein | AAW51124.1 |
| UniProtKB/Swiss-Prot ID | Q5I3B1 |
| UniProtKB/Swiss-Prot Entry Name | IOD3_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | AAFC03027682 |
| GeneCard ID | DIO3 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |