| Identification |
|---|
| BMDB Protein ID
| BMDBP00556 |
| Secondary Accession Numbers
| None |
| Name
| Glycine amidinotransferase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| GATM |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development (By similarity). |
| Pathways
|
- Amine and polyamine biosynthesis
- Arginine and Proline Metabolism
- Creatine biosynthesis
- Creatine from L-arginine and glycine: step 1/2
- Glycine and Serine Metabolism
|
| Reactions
|
| L-Arginine + Glycine → Ornithine + Guanidoacetic acid |
details
|
| Glycine + L-Arginine → Guanidoacetic acid + Orotidylic acid |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| Not Available |
| SNPs
| GATM |
| Gene Sequence
|
>1272 bp
ATGCTGCGGGTGCGGTGTCTGCGCGGCGGGAGCCGCGGTGCCGAAGCGCTGCACTACATC
GGGTCTCGGCTTGGAAGAACTGTAACGGGATGGGTGCAGCGAACTTTCCAGAGCACCCAG
GCAGCTACGGCTTCCTCCCGGAATTCCTGTGCAGCTGATGACAAGGCCACTGATCCTCTG
CCCAAGGACTGCCCTGTCTCCTCTTTCAACGAATGGGACCCCTTAGAGGAAGTGATCGTG
GGCAGAGCAGAAAATGCCTGTGTTCCACCGTTCACTGTGGAGGTGAAGGCCAACACATAT
GACAAGCACTGGCCTTTTTACCAAAAGTATGGGGGCAGTTATTTTCCCAAAGATCATTTG
CAAAAGGCTGTTGCTGAAATTGAAGAAATGTGCAATATTTTAAAAATGGAAGGAGTGACA
GTGAGGAGGCCTGACCCCATTGACTGGTCACTGAAGTATAAAACTCCTGATTTTGAGTCT
ACGGGTTTATATGGCGCGATGCCTCGAGACATCCTGATAGTTGTGGGAAATGAGATTATC
GAGGCTCCCATGGCCTGGCGCGCTCGCTTCTTTGAGTACCGTGCATACAGAACAATTATC
AAAGACTACTTCCGCCGTGGGGCCAAGTGGACAACGGCTCCTAAGCCCACAATGGCTGAT
GAGCTTTATGACCAAGATTACCCCATCCATTCTGTAGAAGACAGACACAAATTGGCTGCT
CAGGGAAAGTTTGTGACAACTGAGTTTGAGCCATGCTTTGATGCTGCTGATTTCATTCGA
GCTGGAAGAGATATCTTCGTACAAAGAAGCCAGGTTACAAACTACATGGGCATTGAATGG
ATGCGTAAGCATCTGGCTCCAGACTACAGAGTGCACATTGTTTCCTTTAAAGACCCCAAT
CCAATGCACATTGATGCCACCTTCAATATCATTGGGCCTGGTCTTGTGCTTTCCAACCCT
GACCGACCATGTCACCAGATTGATCTTTTCAAGAAAGCAGGATGGACCATAGTTACTCCT
CCAACACCAATCATCCCAGATGATCACCCACTCTGGATGTCCTCCAAATGGCTTTCCATG
AATGTCTTAATGCTAGATGAAAAGCGTGTTATGGTGGATGCCAACGAGGTCCCAATTCAG
AAGATGTTTGAAAAGCTGGGTATCAGTACCATTAAGGTTAGCATTCGTAACGCCAATTCC
CTGGGAGGAGGCTTCCACTGCTGGACCTGCGATGTCCGTCGCCGGGGCACCCTGCAGTCC
TACTTTGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 423 |
| Molecular Weight
| 48357.0 |
| Theoretical pI
| 7.97 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Glycine amidinotransferase, mitochondrial
MLRVRCLRGGSRGAEALHYIGSRLGRTVTGWVQRTFQSTQAATASSRNSCAADDKATDPL
PKDCPVSSFNEWDPLEEVIVGRAENACVPPFTVEVKANTYDKHWPFYQKYGGSYFPKDHL
QKAVAEIEEMCNILKMEGVTVRRPDPIDWSLKYKTPDFESTGLYGAMPRDILIVVGNEII
EAPMAWRARFFEYRAYRTIIKDYFRRGAKWTTAPKPTMADELYDQDYPIHSVEDRHKLAA
QGKFVTTEFEPCFDAADFIRAGRDIFVQRSQVTNYMGIEWMRKHLAPDYRVHIVSFKDPN
PMHIDATFNIIGPGLVLSNPDRPCHQIDLFKKAGWTIVTPPTPIIPDDHPLWMSSKWLSM
NVLMLDEKRVMVDANEVPIQKMFEKLGISTIKVSIRNANSLGGGFHCWTCDVRRRGTLQS
YFD
|
| External Links |
|---|
| GenBank ID Protein
| AAI13273.1 |
| UniProtKB/Swiss-Prot ID
| Q2HJ74 |
| UniProtKB/Swiss-Prot Entry Name
| GATM_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC113272 |
| GeneCard ID
| GATM |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
