Showing Protein Arginase-2, mitochondrial (BMDBP00558)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00558 |
| Secondary Accession Numbers | None |
| Name | Arginase-2, mitochondrial |
| Synonyms | Not Available |
| Gene Name | ARG2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Amino acid transport and metabolism |
| Specific Function | May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction. Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling. Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity. |
| Pathways |
|
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 10 |
| Locus | Not Available |
| SNPs | ARG2 |
| Gene Sequence |
>1065 bp ATGTCCCTGAGGAGCCACCTCTCGCGTCTCCTCCGGACGCAAGTGCACTCCGTCCGGAAG AAGTCTGTCCACTCCGTGGCTGTCATTGGAGCCCCATTCTCCCAGGGACAGAAAAGAAAA GGAGTGGAATATGGTCCTGCTGCTGTAAGANAAGCTGGCTTGATGAAAAGGCTCTCGGAT CTGGGCTGCCACCTTAAAGACTTCGGAGATTTGAATTTTACTCCAGTTCCCAAAGATGAT CTCTATAACAACTTGATAGTGAATCCTCGCTCAGTGGGCCTGGCCAACCAGGAACTAGCG GAGGTGGTTAGCCGAGCTGTGTCAGGTGGCTACAGCTGTGTCACGGTGGGAGGAGACCAC AGCCTGGCAATCGGTACCATCAGTGGCCACGCCCGACACTGCCCAGACCTTGGTGTGATC TGGGTTGATGCCCATGCTGACATCAATACACCCCTCACCACTTCATCTGGAAATCTACAT GGACAGCCAGTTTCGTTTCTCCTCAGAGAACTACAGGACAAGGTACCACAGCTCCCAGGA TTTTCCTGGATCAAACCTTGTATCTCTTCTCCAAGTATTGTATATATTGGACTAAGAGAC GTGGACCCTCCTGAACATTTTATTTTAAAGAATTATGATATCCAGTATTTTTCCATGAGA GACATAGATCGACTTGGTATCCAGAAGGTCATGGAACAGACATTCGATCTGCTGATTGGC AAAAGACAAAGGCCAATCCATCTGAGTTTCGATATTGATGCATTTGACCCTACACTGGCT CCAGCCACAGGAACCCCTGTTGTAGGGGGACTGACCTATCGAGAAGGCATATATATTACT GAGGAAATACACAGTACAGGGTTGCTCTCGGCCCTGGACCTCGTTGAAGTCAATCCTCGG TTGGCCGTGTCAGAGGAGGAGGCCAAGGCTACAGCCAGCCTGGCAGTGGACGTCATTGCT TCGAGTTTCGGGCAGACGAGGGAGGGAGGGCATATTGTCTACGACCAACTTCCAACTCCC AGCTCACCAGATGAATCAGAGAGTGAAGAACGTGTAAGAATTTAG |
| Protein Properties | |
| Number of Residues | 354 |
| Molecular Weight | 38616.0 |
| Theoretical pI | 6.45 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Arginase-2, mitochondrial MSLRSHLSRLLRTQVHSVRKKSVHSVAVIGAPFSQGQKRKGVEYGPAAVRXAGLMKRLSD LGCHLKDFGDLNFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSGGYSCVTVGGDH SLAIGTISGHARHCPDLGVIWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPG FSWIKPCISSPSIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMEQTFDLLIG KRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGIYITEEIHSTGLLSALDLVEVNPR LAVSEEEAKATASLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESESEERVRI |
| External Links | |
| GenBank ID Protein | AAX46433.1 |
| UniProtKB/Swiss-Prot ID | Q58DL1 |
| UniProtKB/Swiss-Prot Entry Name | ARGI2_BOVIN |
| PDB IDs | |
| GenBank Gene ID | BT021586 |
| GeneCard ID | ARG2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |