Showing Protein Aspartate aminotransferase, cytoplasmic (BMDBP00567)
| Identification | |||||||||
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| BMDB Protein ID | BMDBP00567 | ||||||||
| Secondary Accession Numbers |
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| Name | Aspartate aminotransferase, cytoplasmic | ||||||||
| Synonyms | Not Available | ||||||||
| Gene Name | GOT1 | ||||||||
| Protein Type | Enzyme | ||||||||
| Biological Properties | |||||||||
| General Function | Amino acid transport and metabolism | ||||||||
| Specific Function | Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain (By similarity). | ||||||||
| Pathways | Not Available | ||||||||
| Reactions |
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| GO Classification | Not Available | ||||||||
| Cellular Location | Not Available | ||||||||
| Gene Properties | |||||||||
| Chromosome Location | 26 | ||||||||
| Locus | Not Available | ||||||||
| SNPs | GOT1 | ||||||||
| Gene Sequence |
>1242 bp ATGGCGCCTCCATCAATCTTTGCCGAGGTTCCTCAGGCCCAGCCGGTCCTTGTCTTTAAG CTAACTGCTGACTTCCGGGAGGATCCGGACCCCCGCAAGGTCAACCTGGGAGTGGGAGCT TATCGCACCGATGATAGCCAGCCCTGGGTTTTACCAGTCGTGAGGAAGGTGGAGCAGAGG ATTGCTAACGACAGCAGCATAAACCATGAGTATCTGCCCATCCTGGGCCTGGCAGAGTTC CGAACTTGTGCTTCCCGCCTGGCCCTTGGGGATGACAGCCCAGCTCTGCAAGAGAAGCGG GTGGGAGGGGTGCAGTGCTTGGGGGGAACAGGTGCACTTCGAATCGGAGCTGAGTTCTTG GCGCGCTGGTACAATGGAACAAACAACAAGGACACACCCGTCTATGTGTCCTCGCCAACC TGGGAGAATCATAATGGTGTCTTTATTGCTGCTGGATTTAAAGACATTCGGTCCTATCAC TATTGGGATGCAGCGAAGAGAGGACTAGACCTCCAGGGTTTCCTGAATGATTTGGAGAAA GCTCCCGAGTTCTCCATCTTTGTCCTCCATGCCTGTGCGCACAACCCGACTGGGACTGAC CCGACTCCGGAGCAGTGGAAGCAGATCGCCTCCGTCATGAAGCGCCGGTTTCTGTTCCCC TTCTTTGACTCGGCCTATCAGGCGTTCGCATCTGGCAGCCTGGAGAAAGACGCCTGGGCC ATTCGCTATTTTGTGTCTGAAGGGTTCGAGCTCTTCTGTGCCCAGTCCTTCTCCAAAAAC TTCGGGCTCTACAATGAGCGTGTGGGGAATCTGACTGTGGTTGCCAAAGAACCAGATAGC ATCCTGCGGGTCCTTTCCCAGATGGAGAAGATCGTGCGAATTACATGGTCCAATCCCCCA GCTCAGGGAGCACGGATCGTGGCACGTACCCTGTCTGATCCTGAGCTCTTTAATGAATGG ACAGGTAACGTGAAGACAATGGCAGACCGCATTCTGACCATGAGATCTGAGCTCAGGGCA CGATTAGAAGCCCTCAAGACCCCAGGAACCTGGAACCACATCACAGAGCAGATCGGAATG TTCAGCTTCACCGGGTTGAACCCCAAGCAGGTTGAGTATCTGATCAATGAAAAGCACATC TATCTGCTGCCAAGTGGTCGGATCAACATGTGTGGCTTAACCACCAAAAATCTAGAGTAC GTGGCCACCTCCATCCATGAAGCAGTCACCAAAATCCAGTGA |
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| Protein Properties | |||||||||
| Number of Residues | 413 | ||||||||
| Molecular Weight | 46399.0 | ||||||||
| Theoretical pI | 7.56 | ||||||||
| Pfam Domain Function | Not Available | ||||||||
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>Aspartate aminotransferase, cytoplasmic MAPPSIFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDSQPWVLPVVRKVEQR IANDSSINHEYLPILGLAEFRTCASRLALGDDSPALQEKRVGGVQCLGGTGALRIGAEFL ARWYNGTNNKDTPVYVSSPTWENHNGVFIAAGFKDIRSYHYWDAAKRGLDLQGFLNDLEK APEFSIFVLHACAHNPTGTDPTPEQWKQIASVMKRRFLFPFFDSAYQGFASGSLEKDAWA IRYFVSEGFELFCAQSFSKNFGLYNERVGNLTVVAKEPDSILRVLSQMEKIVRITWSNPP AQGARIVARTLSDPELFNEWTGNVKTMADRILTMRSELRARLEALKTPGTWNHITEQIGM FSFTGLNPKQVEYLINEKHIYLLPSGRINMCGLTTKNLEYVATSIHEAVTKIQ |
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| External Links | |||||||||
| GenBank ID Protein | CAA46818.1 | ||||||||
| UniProtKB/Swiss-Prot ID | P33097 | ||||||||
| UniProtKB/Swiss-Prot Entry Name | AATC_BOVIN | ||||||||
| PDB IDs | |||||||||
| GenBank Gene ID | X66020 | ||||||||
| GeneCard ID | GOT1 | ||||||||
| GenAtlas ID | Not Available | ||||||||
| HGNC ID | Not Available | ||||||||
| References | |||||||||
| General References | Not Available | ||||||||