| Identification |
|---|
| BMDB Protein ID
| BMDBP00569 |
| Secondary Accession Numbers
| |
| Name
| Aspartate aminotransferase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| GOT2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). |
| Pathways
|
Not Available
|
| Reactions
|
| L-Aspartic acid + Oxoglutaric acid → Oxalacetic acid + L-Glutamic acid |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| Not Available |
| SNPs
| GOT2 |
| Gene Sequence
|
>1293 bp
ATGGCCCTGCTGCACTCTGGCCGCTTCCTGTCCGGAGTCGCCGCGGCTTTCCACCCAGGC
CTCGCTGCCGCGGCTTCTGCCAGAGCCAGCTCCTGGTGGGCTCATGTGGAGATGGGGCCC
CCAGATCCCATCCTGGGAGTAACAGAAGCCTTTAAGAGAGACACCAACAGCAAAAAGATG
AACCTGGGAGTTGGTGCCTACCGGGATGATAATGGAAAGCCTTACGTGCTTCCAAGTGTC
CGGAAGGCGGAGGCCCAGATTGCTGCAAAAAATTTGGATAAAGAATACCTGCCCATTGCG
GGGCTGGCTGAATTTTGTAAGGCATCTGCAGAACTAGCCCTGGGTGAGAACAATGAAGTG
TTGAAAAGTGGCCGGTATGTCACCGTGCAGACCATTTCTGGAACCGGGGCCTTAAGGATC
GGAGCCAGTTTTCTGCAAAGATTTTTTAAGTTCAGCCGGGATGTCTTCCTGCCCAAACCA
ACCTGGGGGAATCATACACCCATCTTCAGGGATGCTGGCATGCAGCTCCAGAGTTATCGG
TACTATGACCCCAAGACGTGCGGCTTTGACTTCACAGGCGCTATTGAGGACATTTCAAAA
ATACCAGCGCAGAGTGTCATTCTCCTGCACGCCTGTGCCCACAACCCCACGGGAGTGGAC
CCTCGTCCTGAGCAGTGGAAGGAGATGGCGACAGTGGTGAAGAAAAACAATCTCTTTGCA
TTCTTTGACATGGCCTACCAAGGCTTTGCCAGTGGCGATGGTAACAAGGATGCCTGGGCT
GTGCGCCACTTCATCGAACAGGGCATTAATGTTTGTCTCTGCCAGTCCTATGCCAAGAAC
ATGGGCTTATACGGTGAGCGTGTGGGAGCCTTCACTGTGGTCTGCAAAGATGCCGAGGAA
GCCAAAAGAGTTGAGTCCCAGTTGAAGATCCTGATCCGTCCCATGTATTCCAACCCCCCT
ATCAATGGGGCCCGGATTGCCTCCACTATTCTCACCAGCCCGGATTTGCGGAAACAATGG
TTGCACGAAGTGAAGGGCATGGCCGACCGCATCATCAGCATGCGGACACAGCTGGTGTCC
AACCTCAAGAAGGAGGGCTCCTCCCACAACTGGCAGCACATCATTGACCAGATCGGCATG
TTTTGTTACACAGGCCTAAAGCCTGAACAGGTGGAGCGGCTGACCAAGGAGTTCTCCATC
TACATGACAAAGGATGGCCGCATCTCTGTGGCAGGGGTCACCTCAGGCAACGTGGCATAC
CTTGCTCACGCCATTCACCAGGTCACCAAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 430 |
| Molecular Weight
| 47514.0 |
| Theoretical pI
| 9.45 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Aspartate aminotransferase, mitochondrial
MALLHSGRFLSGVAAAFHPGLAAAASARASSWWAHVEMGPPDPILGVTEAFKRDTNSKKM
NLGVGAYRDDNGKPYVLPSVRKAEAQIAAKNLDKEYLPIAGLAEFCKASAELALGENNEV
LKSGRYVTVQTISGTGALRIGASFLQRFFKFSRDVFLPKPTWGNHTPIFRDAGMQLQSYR
YYDPKTCGFDFTGAIEDISKIPAQSVILLHACAHNPTGVDPRPEQWKEMATVVKKNNLFA
FFDMAYQGFASGDGNKDAWAVRHFIEQGINVCLCQSYAKNMGLYGERVGAFTVVCKDAEE
AKRVESQLKILIRPMYSNPPINGARIASTILTSPDLRKQWLHEVKGMADRIISMRTQLVS
NLKKEGSSHNWQHIIDQIGMFCYTGLKPEQVERLTKEFSIYMTKDGRISVAGVTSGNVAY
LAHAIHQVTK
|
| External Links |
|---|
| GenBank ID Protein
| CAA80960.1 |
| UniProtKB/Swiss-Prot ID
| P12344 |
| UniProtKB/Swiss-Prot Entry Name
| AATM_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Z25466 |
| GeneCard ID
| GOT2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
