Showing Protein Hydroxyacid-oxoacid transhydrogenase, mitochondrial (BMDBP00595)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00595 |
| Secondary Accession Numbers | None |
| Name | Hydroxyacid-oxoacid transhydrogenase, mitochondrial |
| Synonyms | Not Available |
| Gene Name | ADHFE1 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Energy production and conversion |
| Specific Function | Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 14 |
| Locus | Not Available |
| SNPs | ADHFE1 |
| Gene Sequence |
>1401 bp ATGGCCGCCGCTCGCTCTCGGGTAGTGCACTTGCTGAGGCTTCTGCAACGCGCAGCATGC CAGTGCCCGAGTCATTCTCATACTTATTCCCAAGCTCCTGGACTTTCACCTTCTGGGAAA ACAACAGATTATGCCTTCGAGATGGCTGTTTCAACTATTAGATATGGAGCAGGAGTTACA AAGGAAGTGGGCATGGACCTACAAAGCATGGGTGCTAAAAATGTTTGTTTGATGACAGAC AAGAACCTCTCCCAACTCCCTCCTGTACAGACAGTGATGGATTCCCTAGTGAAGAATGGC ATAAACTTTAAGGTTTATGATCATGTGAGAGTGGAACCAACTGATACAAGCTTCATGGAA GCCATTGAATTTGCCAAAAAGGGAGCTTTCGATGCCTTCCTGGCCGTGGGTGGCGGTTCC ACCATAGACACCTGTAAAGCCGCTAATCTGTATTCATCCAGCCCTGACTCTGACTTCCTA GACTACGTCAATGCCCCCATTGGGAAGGGAAAGCCTGTGACTGTGCCTCTGAAACCTCTG ATCGCAGTTCCAACTACCTCAGGCACTGGGAGCGAAACTACCGGAGTTGCCATTTTTGAC TACGAACACTTGAAAGTAAAAACTGGCATTGCTTCGCGAGCCATCAAACCCACACTCGGC CTGATTGATCCTCTACACACCCTGCACATGCCTGAGCGGGTGGTCGCCAACAGTGGCTTC GATGTGCTCTGCCACGCCCTGGAGTCCTACACTGCCCTCCCATATCACATGCGGAGCCCC TGCCCTTCAAGCCCTATCACTCGGCCAGCCTACCAGGGCAGCAACCCCATCAGTGACATC TGGGCAGTCCACGCACTGCGGATCGTTGCCAAGTATCTGAAGAGGGCTATCAGAAATCCT GATGATCTTGAAGCAAGGTCTAATATGCACTTGGCAAGTGCTTTTGCTGGCATTGGCTTT GGAAATGCTGGTGTTCATCTATGCCATGGAATGTCTTACCCAATTTCTGGCTTAGTGAAG ACTTATAAAGCAAAGGATTACAATGTGGATCATCCCCTGGTGCCTCATGGCCTTTCTGTG GTGCTCACCTCCCCAGCAGTGTTCACATTTACATCACAGATGTTTCCTGAGCGGCACTTG GAAGTGGCAGAAATATTGGGAGCTGACACCCGCACTGCCAGGAGGCCAGATGCTGGGCCT GTCTTGGCAGACACGCTGCGGAAATTCTTATTCGATCTGGATGTGGATGACGGCCTGGCT GCCATTGGCTACTCCAAGGCCGACATCCCCGAGCTGGTGAAAGGAACGCTGCCCCAGGAA AGAGTCACCAAGCTTGCACCACGCCCTCAGTCAGAAGAGGATCTATCTGCTCTGTTTGAA GCATCAATGAAACTGTATTAA |
| Protein Properties | |
| Number of Residues | 466 |
| Molecular Weight | 50343.0 |
| Theoretical pI | 7.65 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Hydroxyacid-oxoacid transhydrogenase, mitochondrial MAAARSRVVHLLRLLQRAACQCPSHSHTYSQAPGLSPSGKTTDYAFEMAVSTIRYGAGVT KEVGMDLQSMGAKNVCLMTDKNLSQLPPVQTVMDSLVKNGINFKVYDHVRVEPTDTSFME AIEFAKKGAFDAFLAVGGGSTIDTCKAANLYSSSPDSDFLDYVNAPIGKGKPVTVPLKPL IAVPTTSGTGSETTGVAIFDYEHLKVKTGIASRAIKPTLGLIDPLHTLHMPERVVANSGF DVLCHALESYTALPYHMRSPCPSSPITRPAYQGSNPISDIWAVHALRIVAKYLKRAIRNP DDLEARSNMHLASAFAGIGFGNAGVHLCHGMSYPISGLVKTYKAKDYNVDHPLVPHGLSV VLTSPAVFTFTSQMFPERHLEVAEILGADTRTARRPDAGPVLADTLRKFLFDLDVDDGLA AIGYSKADIPELVKGTLPQERVTKLAPRPQSEEDLSALFEASMKLY |
| External Links | |
| GenBank ID Protein | AAI49098.1 |
| UniProtKB/Swiss-Prot ID | A6QP15 |
| UniProtKB/Swiss-Prot Entry Name | HOT_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC149097 |
| GeneCard ID | ADHFE1 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |