Showing Protein Trifunctional purine biosynthetic protein adenosine-3 (BMDBP00600)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 11 metabolites
Identification
BMDB Protein ID BMDBP00600
Secondary Accession Numbers None
Name Trifunctional purine biosynthetic protein adenosine-3
Synonyms Not Available
Gene Name GART
Protein Type Enzyme
Biological Properties
General Function Nucleotide transport and metabolism
Specific Function Not Available
Pathways
  • 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.
  • IMP biosynthesis via de novo pathway
  • N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.
  • N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1
  • PATHWAY: Purine metabolism
  • Purine Metabolism
Reactions
Adenosine triphosphate + 5-Phosphoribosylamine + Glycine → ADP + Hydrogen phosphate + Glycineamideribotide details
N10-Formyl-THF + Glycineamideribotide → Tetrahydrofolic acid + 5'-Phosphoribosyl-N-formylglycinamide details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 1
Locus 1q12.1-q12.2
SNPs GART
Gene Sequence 
>3033 bp
ATGGCAGCCCGAGTACTTGTCATTGGCAATGGAGGACGAGAACACACGCTGGCCTGGAAA
CTTGCACAGTCTACTCATGTCAAACAAGTGTTGGTTACCCCAGGAAATGCAGGCACTGCC
TGCTCTGAGAAGATTTCAAATACTGACATCTCAATCAGTGATCATACTGCCCTTGCGCAG
TTCTGCAAAGATGAGAAAATTGAATTCGTAGTTGTTGGACCAGAGGCACCTCTAGCTGCT
GGAATTGTTGGGAACCTGAACTCTGTGGGAGTTCGGTGCTTTGGCCCCACAGCACAAGCA
GCTCAGTTAGAGTCCAGCAAGAGATTTGCCAAAGAGTTTATGGACCGACATGGAATCTCA
ACTGCAAGATGGAGAGCTTTCACTAAACCTAAAGAAGCCTGTGACTTCATTATGAGTGCA
GACTTCCCTGCTTTGGTTGTGAAGGCCAGTGGTCTTGCAGCTGGGAAAGGGGTAATTGTT
GCCAAGAGCAAAGAGGAGGCCTGTGAAGCTGTCAGAGAGATTATGCAGGGTAAAGCTTTC
GGAGAAGCAGGAGAAACAGTTGTCATTGAAGAACTTCTTGAAGGAGAAGAGGTGTCTTGT
CTGTGCTTCACTGATGGACGGACTGTGGCCCCCATGCCCCCAGCACAGGACCATAAGCGA
TTGCTGGAGGGCGATGAGGGCCCCAACACGGGAGGAATGGGAGCCTATTGTCCAGCCCCT
CAGGTTTCTAAGGATTTGTTGCTAAAAATTAAAAATAATATTCTTCAGAGGACAGTGGAT
GGCATGCAGGAGGAGGGTATGCCATACACAGGTGTCCTCTATGCTGGTATAATGCTGACC
AAGAACGGCCCCAAAGTTCTGGAATTTAATTGCCGTTTCGGTGATCCAGAGTGCCAAGTG
ATCCTCCCACTTCTTAAAAGTGATCTTTATGAAGTGATTCAGTCTATCTTAGATGGCTTG
CTCTGCACTTCTCTGCCTGTTTGGCTGGACAACTGTGCTGCCGTAACTGTGGTCATGGCA
AGTAAAGGTTATCCAGGAGACTACACCAAGGGTGTAGAGATAACAGGGTTTCCTGAGGCT
CAGGCTTTAGGACTGGAGGTGTTCCAAGCAGGCACTGCCCTAAAAGATGGCAAGGTGGTG
ACTAACGGGGGTAGGGTCCTTACTGTCACGGCCATCAGGGAAAATCTCATCTCAGCTCTT
GAAGAAGCCAGGAAAGGACTTGCCGCCATAAAGTTTGAGGGAGCTGTTTATAGGAAAGAC
ATCGGCTTTCGAGCCATAGCTTTCCTCCAGCAGCCCAGGGGCCTGACTTACAAGGAATCT
GGGGTAGACATTGCAGCTGGTAATATGCTGGTCCAGAAAATTAAACCTTTAGCGAAGGCC
ACCTCCAGACCAGGCTGTGATGTTGATCTTGGAGGTTTTGCTGGTCTTTTTGATTTGAAA
GCAGCTGGTTTCACTGATCCTCTTCTGGCTTGTGGAACAGATGGTGTTGGGACGAAACTG
AAGATTGCCCAGCAGTGCAGTAAACATGACACCATTGGTCAGGATTTGGTTGCGATGTGT
GTAAATGACATTCTGGCACAAGGAGCAGAGCCCCTCTTTTTCCTCGATTACTTTTCCTGT
GGAAAACTTGACCTCCGTACTACTGAAGCTGTTATCACTGGGATCGCCAAAGCTTGTAAA
AAGGCTGGATGTGCTCTCCTCGGAGGTGAAACGGCAGAGATGCCTGACATGTACCCTCCT
GGAGAGTATGATCTAGCTGGTTTTGCCGTTGGCGCCATGGAGCGGGATCAGAAACTTCCT
CAACTGGAAAGAATCACGGAAGGAGACGCTGTTATTGGAATCGCTTCATCTGGTCTTCAC
AGCAACGGATTCAGCCTTGTGAGGAAAATTGTAGCAAAATCTTCTCTCGAGTACTCTTCT
CCAGCACCTGGTGGCTGTGGTGACCAGACCTTAGGTGACTTACTTCTAACCCCAACCAAA
ATCTACAGCCGCTCACTGTTACCTGTCCTGCGTTCAGGACGTGTTAAGGCCGTTGCACAT
ATTACTGGTGGAGGATTACTGGAAAACATCCCCAGAGTCCTCCCTCAGAAATTGGGGGTG
AATTTAGATGCCCAGACCTGGAGGGTCCCCAGGATCTTCTCATGGTTACAGCAGGAAGGC
CACCTCTCTGAAGAGGAGATGGCCAGAACATTTAACTGTGGGATTGGGGCTGCCCTCGTG
GTATCAGAGGACCTGGTGAAGCAGACTCTGCAGGATATTGAGCAGCACCAGGAAGAAGCC
TGCGTGATCGGCAGAGTGGTTGCATGTCCCAAGGGTTCTCCTCGTGTGAAAGTCGAGCAT
CTGATTGAAACCATGCAAATAAATGGATCAGTATTGGAGAATGGAACCCTGAGAAATCAT
TTCTCTGTTCAACCAAAAAAGGCAAGAGTAGCTGTCTTAATTTCTGGGACAGGATCAAAC
CTCCAAGCTCTCATAGACAGCACTAGGGAGCCAAGTAGCTTGGCACACATTGTCATTGTG
ATCTCCAACAAAGCTGCAGTGGCTGGGTTAGATAAAGCAGAAAAAGCCGGGATTCCCACG
AGAGTAATTAATCATAAATTATATAAAAATCGTGCAGCATTTGACACTGCAATTGACGAA
GTCCTTGAAGAGTTCTCCACAGACATAGTCTGTCTTGCAGGATTCATGAGAATTTTGTCT
GGCCCCTTCGTCAGAAAATGGAATGGGAAAATGCTCAATATCCACCCATCCTTGCTCCCT
TCGTTTAAGGGTTCAAATGCCCATGAACAAGTCCTGGATGCTGGGGTCACAGTCACCGGG
TGCACCGTGCACTTTGTAGCTGAAGATGTAGATGCCGGTCAAATTATCTTACAGGAAGCC
GTTCCAGTGAAGAGGGGTGACACTGTTGAAACTCTATCTGAGAGAGTAAAATTAGCAGAA
CATAAAATATTTCCCTCAGCCCTCCAGCTGGTGGCCAGTGGAGCTGTACGGCTTGGAGAA
AATGGCAGAATCTGTTGGGTCACAGAGGACTGA
Protein Properties
Number of Residues 1010
Molecular Weight 107907.0
Theoretical pI 6.34
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence 
>Trifunctional purine biosynthetic protein adenosine-3
MAARVLVIGNGGREHTLAWKLAQSTHVKQVLVTPGNAGTACSEKISNTDISISDHTALAQ
FCKDEKIEFVVVGPEAPLAAGIVGNLNSVGVRCFGPTAQAAQLESSKRFAKEFMDRHGIS
TARWRAFTKPKEACDFIMSADFPALVVKASGLAAGKGVIVAKSKEEACEAVREIMQGKAF
GEAGETVVIEELLEGEEVSCLCFTDGRTVAPMPPAQDHKRLLEGDEGPNTGGMGAYCPAP
QVSKDLLLKIKNNILQRTVDGMQEEGMPYTGVLYAGIMLTKNGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVIQSILDGLLCTSLPVWLDNCAAVTVVMASKGYPGDYTKGVEITGFPEA
QALGLEVFQAGTALKDGKVVTNGGRVLTVTAIRENLISALEEARKGLAAIKFEGAVYRKD
IGFRAIAFLQQPRGLTYKESGVDIAAGNMLVQKIKPLAKATSRPGCDVDLGGFAGLFDLK
AAGFTDPLLACGTDGVGTKLKIAQQCSKHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDLRTTEAVITGIAKACKKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLP
QLERITEGDAVIGIASSGLHSNGFSLVRKIVAKSSLEYSSPAPGGCGDQTLGDLLLTPTK
IYSRSLLPVLRSGRVKAVAHITGGGLLENIPRVLPQKLGVNLDAQTWRVPRIFSWLQQEG
HLSEEEMARTFNCGIGAALVVSEDLVKQTLQDIEQHQEEACVIGRVVACPKGSPRVKVEH
LIETMQINGSVLENGTLRNHFSVQPKKARVAVLISGTGSNLQALIDSTREPSSLAHIVIV
ISNKAAVAGLDKAEKAGIPTRVINHKLYKNRAAFDTAIDEVLEEFSTDIVCLAGFMRILS
GPFVRKWNGKMLNIHPSLLPSFKGSNAHEQVLDAGVTVTGCTVHFVAEDVDAGQIILQEA
VPVKRGDTVETLSERVKLAEHKIFPSALQLVASGAVRLGENGRICWVTED
GenBank ID Protein CAG47113.1
UniProtKB/Swiss-Prot ID Q59A32
UniProtKB/Swiss-Prot Entry Name PUR2_BOVIN
PDB IDs Not Available
GenBank Gene ID AJ780930
GeneCard ID GART
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available