| Identification |
|---|
| BMDB Protein ID
| BMDBP00601 |
| Secondary Accession Numbers
| |
| Name
| Retinal dehydrogenase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| ALDH1A1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal. May have a broader specificity and oxidize other aldehydes in vivo. |
| Pathways
|
- Cofactor metabolism
- Retinol Metabolism
|
| Reactions
|
| N10-Formyl-THF + NADP + Water → Tetrahydrofolic acid + Carbon dioxide + NADPH |
details
|
| 9-cis-Retinal + NAD + Water → 9-cis-Retinoic acid + NADH |
details
|
| Vitamin A + NAD + Water → Retinoic acid + NADH |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| ALDH1A1 |
| Gene Sequence
|
>1506 bp
ATGTCGTCCTCAGCCATGCCAGACGTACCTGCCCCACTCACCAATTTGCAGTTTAAATAT
ACTAAGATCTTCATAAACAATGAATGGCATAGTTCAGTGAGTGGTAAGAAATTTCCAGTC
TTTAATCCTGCAACTGAGGAGAAACTCTGTGAGGTGGAAGAAGGAGATAAGGAGGATGTT
GACAAAGCAGTGAAGGCTGTAAGACAAGCTTTTCAGATTGGCTCTCCATGGCGTACTATG
GATGCTTCAGAGAGAGGACGGCTGTTAAACAAGTTGGCTGACTTAATTGAAAGAGATCAT
CTGCTCCTGGCGACAATGGAGGCAATGAATGGTGGAAAACTATTTTCCAATGCATATCTG
ATGGATTTAGGAGGCTGCATAAAAACACTACGCTACTGTGCAGGCTGGGCTGACAAGATC
CAGGGCCGCACAATACCCATGGATGGAAACTTTTTTACATATACAAGAAGTGAGCCTGTT
GGTGTGTGTGGCCAAATCATTCCTTGGAATTTCCCATTGCTCATGTTCCTCTGGAAGATA
GGGCCTGCCCTTAGCTGCGGAAACACAGTGGTTGTCAAACCAGCAGAGCAAACCCCTCTG
ACTGCTCTTCACATGGGATCTTTAATAAAAGAGGCAGGGTTTCCTCCTGGAGTAGTGAAT
ATTGTCCCTGGTTATGGGCCTACTGCAGGGGCAGCCATTTCTTCTCACATGGATGTAGAC
AAAGTGGCCTTCACAGGATCGACAGAGGTTGGCAAACTGATCAAAGAAGCTGCTGGGAAA
AGCAATCTGAAAAGGGTGTCCCTGGAACTCGGGGGAAAGAGTCCTTGCATTGTGTTTGCT
GATGCCGACTTGGACAATGCTGTTGAATTTGCACACCAAGGAGTATTCTATCACCAGGGC
CAGTGTTGTATAGCTGCATCCCGTCTCTTTGTAGAAGAATCAATTTACGATGAGTTTGTT
CGAAGGAGTGTTGAGCGGGCGAAAAAGTATGTTCTTGGAAATCCTCTGACCCCAGGAGTC
AGTCAAGGCCCTCAGATTGATAAAGAACAATATGAAAAAATACTTGACCTCATTGAAAGT
GGGAAGAAGGAGGGGGCCAAGCTGGAATGTGGCGGAGGCCCTTGGGGGAATAAAGGCTAC
TTTATCCAACCCACAGTTTTCTCTGATGTTACTGATGATATGCGCATTGCCAAAGAGGAG
ATATTTGGACCTGTGCAGCAAATCATGAAGTTTAAGTCTTTAGATGATGTAATCAAGAGA
GCAAACAATACTTTCTATGGGTTATCTGCAGGAATATTTACCAATGATATTGATAAAGCC
ATCACAGTCTCCTCTGCTTTGCAGTCTGGAACCGTGTGGGTGAACTGCTATAGTGTGGTA
TCTGCCCAGTGCCCCTTTGGTGGATTCAAGATGTCTGGAAATGGTCGAGAACTGGGAGAA
TATGGTTTCCATGAATACACAGAAGTCAAGACGGTCACAATCAAAATTTCTCAGAAGAAC
TCATAA
|
| Protein Properties |
|---|
| Number of Residues
| 501 |
| Molecular Weight
| 54806.0 |
| Theoretical pI
| 6.62 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Retinal dehydrogenase 1
MSSSAMPDVPAPLTNLQFKYTKIFINNEWHSSVSGKKFPVFNPATEEKLCEVEEGDKEDV
DKAVKAARQAFQIGSPWRTMDASERGRLLNKLADLIERDHLLLATMEAMNGGKLFSNAYL
MDLGGCIKTLRYCAGWADKIQGRTIPMDGNFFTYTRSEPVGVCGQIIPWNFPLLMFLWKI
GPALSCGNTVVVKPAEQTPLTALHMGSLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDVD
KVAFTGSTEVGKLIKEAAGKSNLKRVSLELGGKSPCIVFADADLDNAVEFAHQGVFYHQG
QCCIAASRLFVEESIYDEFVRRSVERAKKYVLGNPLTPGVSQGPQIDKEQYEKILDLIES
GKKEGAKLECGGGPWGNKGYFIQPTVFSDVTDDMRIAKEEIFGPVQQIMKFKSLDDVIKR
ANNTFYGLSAGIFTNDIDKAITVSSALQSGTVWVNCYSVVSAQCPFGGFKMSGNGRELGE
YGFHEYTEVKTVTIKISQKNS
|
| External Links |
|---|
| GenBank ID Protein
| AAA74234.1 |
| UniProtKB/Swiss-Prot ID
| P48644 |
| UniProtKB/Swiss-Prot Entry Name
| AL1A1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| L36128 |
| GeneCard ID
| ALDH1A1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
