Showing Protein Carbonyl reductase [NADPH] 1 (BMDBP00602)
| Identification | |||||
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| BMDB Protein ID | BMDBP00602 | ||||
| Secondary Accession Numbers | None | ||||
| Name | Carbonyl reductase [NADPH] 1 | ||||
| Synonyms | Not Available | ||||
| Gene Name | CBR1 | ||||
| Protein Type | Enzyme | ||||
| Biological Properties | |||||
| General Function | Lipid transport and metabolism | ||||
| Specific Function | NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (By similarity). | ||||
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| Reactions |
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| GO Classification | Not Available | ||||
| Cellular Location | Not Available | ||||
| Gene Properties | |||||
| Chromosome Location | 1 | ||||
| Locus | Not Available | ||||
| SNPs | CBR1 | ||||
| Gene Sequence |
>834 bp ATGTCGTCCTCCAACTGCGTGGCGCTGGTCACCGGGGCCAACAAGGGCATCGGCTTCGTC ATCGTGCGTGACCTGTGCCGGCGGTTCTCGGGCGACGTGGTGCTCACGGCGCGGGACGAG GCGCGGGGTCGGGCGGCCGTGCAGCAGCTGCAGGCTGAGGGCCTGAGCCCCCTTTTCCAC CAGCTGGACATCGACGACCGGCAGAGCATCCGCGCCCTGCGTGACTTCCTGCGCAAGGAG TACGGGGGCCTCGATGTGCTGGTCAACAACGCGGGCATTGCCTTCAAGACTGCTGACACC ACACCATTTCACATTCAAGCAGAGGTGACTATGAAAACAAACTTCTTTGGCACCAGAGAT GTGTGCACGGAGCTCCTGCCTCTAATAAAACCGCAAGGCAGAGTGGTGAATGTATCCAGC TTTGTCAGTGTCAACTCTCTAAAGAAATGCAGCCGTGAACTGCAGCAGAAGTTTCGAAGT GAGACCATCACAGAGGAGGAGCTGGTGGGGCTCATGAACAAGTTTGTGGAAGACACAAAG AACGGGGTGCACAGGAAGGAGGGCTGGCCCGATACCGCATATGGAGTGACGAAAATTGGA GTCACAGTCCTGTCCAGAATCCACGCCAGGAAACTGAGTGAGCAGAGAGGAGGGGACAAG ATCCTCCTGAACGCCTGCTGCCCAGGGTGGGTGAGAACCGACATGGGGGGACCCAAAGCC TCCAAAAGCCCAGAAGAAGGAGCAGAGACCCCCGTGTACTTGGCCCTTCTGCCCTCAGAT GCTGAGGGGCCTCACGGAGAGTTCATTTCTGAGAAAAGAGTTGTGCAATGGTGA |
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| Protein Properties | |||||
| Number of Residues | 277 | ||||
| Molecular Weight | 30533.0 | ||||
| Theoretical pI | 8.37 | ||||
| Pfam Domain Function | Not Available | ||||
| Signals |
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| Transmembrane Regions | Not Available | ||||
| Protein Sequence |
>Carbonyl reductase [NADPH] 1 MSSSNCVALVTGANKGIGFVIVRDLCRRFSGDVVLTARDEARGRAAVQQLQAEGLSPLFH QLDIDDRQSIRALRDFLRKEYGGLDVLVNNAGIAFKTADTTPFHIQAEVTMKTNFFGTRD VCTELLPLIKPQGRVVNVSSFVSVNSLKKCSRELQQKFRSETITEEELVGLMNKFVEDTK NGVHRKEGWPDTAYGVTKIGVTVLSRIHARKLSEQRGGDKILLNACCPGWVRTDMGGPKA SKSPEEGAETPVYLALLPSDAEGPHGEFISEKRVVQW |
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| External Links | |||||
| GenBank ID Protein | AAI02944.1 | ||||
| UniProtKB/Swiss-Prot ID | Q3SZD7 | ||||
| UniProtKB/Swiss-Prot Entry Name | CBR1_BOVIN | ||||
| PDB IDs | Not Available | ||||
| GenBank Gene ID | BC102943 | ||||
| GeneCard ID | CBR1 | ||||
| GenAtlas ID | Not Available | ||||
| HGNC ID | Not Available | ||||
| References | |||||
| General References | Not Available | ||||