| Identification |
|---|
| BMDB Protein ID
| BMDBP00602 |
| Secondary Accession Numbers
| None |
| Name
| Carbonyl reductase [NADPH] 1 |
| Synonyms
|
Not Available
|
| Gene Name
| CBR1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (By similarity). |
| Pathways
|
- Arachidonic Acid Metabolism
- Pterine Biosynthesis
|
| Reactions
|
| Prostaglandin E2 + NADPH → Prostaglandin F2a + NADP |
details
|
| Sepiapterin + NADP → 7,8-Dihydroneopterin + NADPH |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| Not Available |
| SNPs
| CBR1 |
| Gene Sequence
|
>834 bp
ATGTCGTCCTCCAACTGCGTGGCGCTGGTCACCGGGGCCAACAAGGGCATCGGCTTCGTC
ATCGTGCGTGACCTGTGCCGGCGGTTCTCGGGCGACGTGGTGCTCACGGCGCGGGACGAG
GCGCGGGGTCGGGCGGCCGTGCAGCAGCTGCAGGCTGAGGGCCTGAGCCCCCTTTTCCAC
CAGCTGGACATCGACGACCGGCAGAGCATCCGCGCCCTGCGTGACTTCCTGCGCAAGGAG
TACGGGGGCCTCGATGTGCTGGTCAACAACGCGGGCATTGCCTTCAAGACTGCTGACACC
ACACCATTTCACATTCAAGCAGAGGTGACTATGAAAACAAACTTCTTTGGCACCAGAGAT
GTGTGCACGGAGCTCCTGCCTCTAATAAAACCGCAAGGCAGAGTGGTGAATGTATCCAGC
TTTGTCAGTGTCAACTCTCTAAAGAAATGCAGCCGTGAACTGCAGCAGAAGTTTCGAAGT
GAGACCATCACAGAGGAGGAGCTGGTGGGGCTCATGAACAAGTTTGTGGAAGACACAAAG
AACGGGGTGCACAGGAAGGAGGGCTGGCCCGATACCGCATATGGAGTGACGAAAATTGGA
GTCACAGTCCTGTCCAGAATCCACGCCAGGAAACTGAGTGAGCAGAGAGGAGGGGACAAG
ATCCTCCTGAACGCCTGCTGCCCAGGGTGGGTGAGAACCGACATGGGGGGACCCAAAGCC
TCCAAAAGCCCAGAAGAAGGAGCAGAGACCCCCGTGTACTTGGCCCTTCTGCCCTCAGAT
GCTGAGGGGCCTCACGGAGAGTTCATTTCTGAGAAAAGAGTTGTGCAATGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 277 |
| Molecular Weight
| 30533.0 |
| Theoretical pI
| 8.37 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Carbonyl reductase [NADPH] 1
MSSSNCVALVTGANKGIGFVIVRDLCRRFSGDVVLTARDEARGRAAVQQLQAEGLSPLFH
QLDIDDRQSIRALRDFLRKEYGGLDVLVNNAGIAFKTADTTPFHIQAEVTMKTNFFGTRD
VCTELLPLIKPQGRVVNVSSFVSVNSLKKCSRELQQKFRSETITEEELVGLMNKFVEDTK
NGVHRKEGWPDTAYGVTKIGVTVLSRIHARKLSEQRGGDKILLNACCPGWVRTDMGGPKA
SKSPEEGAETPVYLALLPSDAEGPHGEFISEKRVVQW
|
| External Links |
|---|
| GenBank ID Protein
| AAI02944.1 |
| UniProtKB/Swiss-Prot ID
| Q3SZD7 |
| UniProtKB/Swiss-Prot Entry Name
| CBR1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC102943 |
| GeneCard ID
| CBR1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
