Showing Protein Transketolase-like protein 2 (BMDBP00608)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00608 |
| Secondary Accession Numbers | None |
| Name | Transketolase-like protein 2 |
| Synonyms | Not Available |
| Gene Name | TKTL2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Energy production and conversion |
| Specific Function | Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 6 |
| Locus | Not Available |
| SNPs | TKTL2 |
| Gene Sequence |
>1881 bp ATGGCGGACAGCGCGACACTGGACGCGACCACAGTGCAAGTGCTGCAGGACCTGGCCAAC CGCCTGCGCGTCCATTCCATCAGGGCTACATGTGCCTCTGGCTCCGGCCACCCCACGTCG TGCTGCAGTGCGGCAGAGATCGTGTCGGTGCTTTTCTTCCACACGATGAGGTACAGACAG ACTGAGCCCGCGCACCCCGACAACGACAGATTCGTCCTTTCCAAGGGTCATGCCGCTCCA CTGCTCTATGCTGCCTGGGTGGAGGCAGGCAGCATCAGTGAACCTGACCTGCTGAACTTG AGGACAATTCATTGCGACCTTGAGGGACACCCCACCCCCAGGCTGTCGTTTGTGGATGTG GCGACAGGATCGCTCGGGCAAGGTTTGGGGGCTGCATGTGGAATGGCTTATACTGGCAAG TACTTGGACAAAGCCAGCTACCGGGTATTCTGCCTCCTGGGCGACGGTGAGTCCTCAGAA GGCTCCGTCTGGGAAGCTTTGGCTTTTGCTTCCCACTACGGTTTGGACAATCTCGTAGCA GTGTTCGACGTGAACCGCTTGGGGCAAAGTGGCGTTGCGCCCCTGAAGCACTGCACAGAC ATCTATCGGAATCGCTGCGAGGCCTTTGGGTGGAATACTTACTTAGTAGATGGCCATGAT GTGGAGGCGTTGTGCCAGGCTTTTTCTCAAGCTGCTCAAGGGAAGAACAAGCCCACTGCC ATAATTGCAAAGACCTACAAGGGCCGGGGTATTCCAAATGTTGAGGATGCAGAAAATTGG CATGGAAAGCCACTGCCAAAAGAAAGAGCAGATGAAATCATTAGACTAATTAAAAGTCAG ATAAAGACCAACAGGAATCTCCTACCAAAACCTCCTGTTGAAGGCTCACCTCCAGTCAGC ATCACAAATATAAAAATGACCTGTTTGCCTGATTATAAAGTTGGTGACAAGGTAGCTACT CAGAAAGCATATGGTTTGGCTCTGGCTAAACTCGGCCTTGCAAATGAAAGAGTTGTTGTC CTGGATGGTGACCCAAAGAACTCCACCTTTTTTGAAATATTCAAGAAAGAACATCCTGAG CGTTTTATTGAGTGTTTTGCTGCGGAACAAAACATGGTGAGTGTGGCACTGGGCTGTGCC ACACGTGGTCGAACCATTACTTTTGTTACTACTTTAGGTGCCTTTTTGACTAGAGCATTT GATCAGATCCGGATGGGAGCCATATCTCAAAGTAATATAAATCTTATTGGTTCTCACTGT GGGGTGTCTGTTGGTGAAGATGGCCCTTCCCAGATGGCTTTGGAAGATCTAGCCATGTTC CGGAGCATTCCCAATTGCACTGTTTTCCTCCCAAGTGATGCTGTCTCGACAGAGCATGCT GTTTATCTGGCTGCCAATAGCGAAGGAATGTGCTTCATTCGGACCAACCGATCAGAAACT GCAGTTATTTATACCCCACAAGAACATTTTGAGATTGGAAGGGCCAAGGTCATCCGCCAC AGTAATAATGACAAAGTCACAGTAATTGGAGCTGGAGTTACTCTGCATGAAGCCTTAGCA GCTGCTGATGCTCTTTCTCAGCAAGATATTTCTATCTGTGTTATTGACCCATTTACCATT AAACCCCTGGATGCTGCCACCATCATCTCCTGTGCAAAAGCTACTGATGGCCGGGTTGTC ACAGTGGAAGATCATTACCAGGAAGGTGGCATTGGCGAAGCCGTGTGTGCAGCAGTGTCT GGGGAGCCTGCCATCCATGTTCATCAGCTATCGGTGTCAGGAGTGTCTGAAAGAAACAGG AAACCTAGTGAATTACTGAGTATATTTGGTGTCAGTGCAAGACACATCATAGCAGCTGTG AAATATACTTTAATGAACTAA |
| Protein Properties | |
| Number of Residues | 626 |
| Molecular Weight | 67501.0 |
| Theoretical pI | 6.62 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Transketolase-like protein 2 MADSATLDATTVQVLQDLANRLRVHSIRATCASGSGHPTSCCSAAEIVSVLFFHTMRYRQ TEPAHPDNDRFVLSKGHAAPLLYAAWVEAGSISEPDLLNLRTIHCDLEGHPTPRLSFVDV ATGSLGQGLGAACGMAYTGKYLDKASYRVFCLLGDGESSEGSVWEALAFASHYGLDNLVA VFDVNRLGQSGVAPLKHCTDIYRNRCEAFGWNTYLVDGHDVEALCQAFSQAAQGKNKPTA IIAKTYKGRGIPNVEDAENWHGKPLPKERADEIIRLIKSQIKTNRNLLPKPPVEGSPPVS ITNIKMTCLPDYKVGDKVATQKAYGLALAKLGLANERVVVLDGDPKNSTFFEIFKKEHPE RFIECFAAEQNMVSVALGCATRGRTITFVTTLGAFLTRAFDQIRMGAISQSNINLIGSHC GVSVGEDGPSQMALEDLAMFRSIPNCTVFLPSDAVSTEHAVYLAANSEGMCFIRTNRSET AVIYTPQEHFEIGRAKVIRHSNNDKVTVIGAGVTLHEALAAADALSQQDISICVIDPFTI KPLDAATIISCAKATDGRVVTVEDHYQEGGIGEAVCAAVSGEPAIHVHQLSVSGVSERNR KPSELLSIFGVSARHIIAAVKYTLMN |
| External Links | |
| GenBank ID Protein | AAI11321.1 |
| UniProtKB/Swiss-Prot ID | Q2NKZ4 |
| UniProtKB/Swiss-Prot Entry Name | TKTL2_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC111320 |
| GeneCard ID | TKTL2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |