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Identification |
BMDB Protein ID
| BMDBP00610 |
Secondary Accession Numbers
| None |
Name
| Leukotriene A-4 hydrolase |
Synonyms
|
Not Available
|
Gene Name
| LTA4H |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Amino acid transport and metabolism |
Specific Function
| Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity (By similarity). |
Pathways
|
- Arachidonic Acid Metabolism
- Leukotriene B4 biosynthesis
- Lipid metabolism
|
Reactions
|
Leukotriene A4 + Water → 6-trans-Leukotriene B4 |
details
|
|
GO Classification
|
Not Available
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| 5 |
Locus
| Not Available |
SNPs
| LTA4H |
Gene Sequence
|
>1836 bp
ATGCCCGAGGTAGTGGATACGTGCTCCTTGGCCTCCCCGGCGTCCGTCTGCCAGACCAAA
CACCTGCACCTGCGTTGCAGCATCGACTTTACTCGCCGGGTACTGAGCGGGACCGCCGCG
CTCACCATCCAGTCCCAGGAGGACAATCTGCGCAGCCTGATTCTGGATACAAAGGACCTC
ACAATAGAAAAAGTGGTCATCAATGGACAAGAAGTCAAATATACTCTTGGAGAAAGACAA
AGTTACAAAGGATCACCAATCGAAATCTCTCTTCCTATTGCTCTATGCAAAAATCAAGAA
ATTGTTATAGAGATTTCTTTCGAGACATCTCCAAAATCTTCTGCTCTTCAGTGGCTCACT
CCTGAACAAACTTCTGGGAAAGAGCACCCCTATCTCTTTAGTCAGTGCCAGGCTATCCAC
TGTAGAGCTATTCTTCCTTGCCAGGACACTCCTTCCGTGAAATTAACCTACAGCGCAGAG
GTGTCTGTCCCCAAAGAACTGGTGGCACTTATGAGTGCCATTCGTGACGGAGAAGCACCT
GACCCAGAAGACCCGAACAGGAAAATTTACAGATTCAGCCAAAAAGTTCCAATCCCCTGC
TACCTGATTGCTTTGGTTGTTGGAGCTTTAGAAAGCAGACAGATTGGCCCAAGGACATTG
GTATGGTCCGAGAAAGAGCAGGTGGAAAAGTCTGCTTACGAATTTTCTGAGACTGAATCT
ATGCTTAAAATTGCAGAAGATCTGGGAGGCCCATATATTTGGGGGCAGTATGACCTATTG
GTCCTGCCGCCATCCTTTCCCTATGGCGGCATGGAGAACCCTTGCCTCACTTTTGTAACT
CCTACTCTGCTGGCTGGTGACAAGTCACTCTCCAATGTTATAGCACATGAAATATCTCAT
AGTTGGACAGGAAATCTAGTGACCAACAAAACTTGGGATCACTTTTGGTTAAATGAAGGA
CATACCGTATACTTGGAACGCCACATTTGTGGACGACTGTTTGGTGAAAAGTTTAGACAT
TTTCACGCTCTGGGCGGATGGGGAGAACTCCAGAATTCGATAAAGACTTTTGGGGAGACC
CATCCTTTCACCAAACTCGTGGTTGACCTGACGAACACAGACCCTGACGTGGCATATTCT
TCAGTTCCCTATGAGAAGGGCTTTGCTTTACTCTTTTACCTTGAACAGCTTCTTGGAGGA
CCAGAGGTTTTCCTAGGATTCTTAAAGGCTTATGTTGAGAAATTTTCCTACAAGAGCATA
ACTACTGATAACTGGAAGGATTTCTTGTATTCCCACTTTAAAGATAAGGTTGATATTCTC
AATCAAGTGGATTGGAACACCTGGCTGTACTCTCCTGGACTGCCCCCTGTAAAACCCAAT
TATGATATGACCCTGACAAATGCTTGCATTTCCTTGAGTCAAAGATGGATCACTGCCAAA
GATGATGATTTAAATTCATTCAGCTCAGCAGACCTAAAAGACTTCTCTTCCCATCAAGTG
AATGAATTTTTAGCACAGATGCTCCAGAATGCACCTCTTCCATTGGGGCACATAAAGCGA
ATGCAAGAGGTGTACAACTTCAATGCCATTAACAATTCTGAAATACGATTCAGATGGTTA
CGACTCTGCATTCAATCGAAATGGGAGGAAGCAATTCCTTTGGCTCTAAAAATGGCAACT
GAACAAGGAAGGATGAAGTTTACACGGCCCTTATTCAAGGACCTTGCTGCCTTTGACAAA
TCCCATGATCAAGCCATCCGTACCTACAAGGAGCACAAGGCATCCATGCACCCTGTGACT
GCCATGCTTGTGGGGAAAGATTTAAAAGTGGATTAA
|
Protein Properties |
Number of Residues
| 611 |
Molecular Weight
| 69306.0 |
Theoretical pI
| 6.33 |
Pfam Domain Function
|
Not Available |
Signals
|
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Leukotriene A-4 hydrolase
MPEVVDTCSLASPASVCQTKHLHLRCSIDFTRRVLSGTAALTIQSQEDNLRSLILDTKDL
TIEKVVINGQEVKYTLGERQSYKGSPIEISLPIALCKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYSAEVSVPKELVALMSAIRDGEAP
DPEDPNRKIYRFSQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYIWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNSIKTFGET
HPFTKLVVDLTNTDPDVAYSSVPYEKGFALLFYLEQLLGGPEVFLGFLKAYVEKFSYKSI
TTDNWKDFLYSHFKDKVDILNQVDWNTWLYSPGLPPVKPNYDMTLTNACISLSQRWITAK
DDDLNSFSSADLKDFSSHQVNEFLAQMLQNAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAIRTYKEHKASMHPVT
AMLVGKDLKVD
|
External Links |
GenBank ID Protein
| AAI02853.1 |
UniProtKB/Swiss-Prot ID
| Q3SZH7 |
UniProtKB/Swiss-Prot Entry Name
| LKHA4_BOVIN |
PDB IDs
|
|
GenBank Gene ID
| BC102852 |
GeneCard ID
| LTA4H |
GenAtlas ID
| Not Available |
HGNC ID
| Not Available |
References |
General References
| Not Available |