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Identification
BMDB Protein ID BMDBP00610
Secondary Accession Numbers None
Name Leukotriene A-4 hydrolase
Synonyms Not Available
Gene Name LTA4H
Protein Type Enzyme
Biological Properties
General Function Amino acid transport and metabolism
Specific Function Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity (By similarity).
Pathways
  • Arachidonic Acid Metabolism
  • Leukotriene B4 biosynthesis
  • Lipid metabolism
Reactions
Leukotriene A4 + Water → 6-trans-Leukotriene B4 details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 5
Locus Not Available
SNPs LTA4H
Gene Sequence
>1836 bp
ATGCCCGAGGTAGTGGATACGTGCTCCTTGGCCTCCCCGGCGTCCGTCTGCCAGACCAAA
CACCTGCACCTGCGTTGCAGCATCGACTTTACTCGCCGGGTACTGAGCGGGACCGCCGCG
CTCACCATCCAGTCCCAGGAGGACAATCTGCGCAGCCTGATTCTGGATACAAAGGACCTC
ACAATAGAAAAAGTGGTCATCAATGGACAAGAAGTCAAATATACTCTTGGAGAAAGACAA
AGTTACAAAGGATCACCAATCGAAATCTCTCTTCCTATTGCTCTATGCAAAAATCAAGAA
ATTGTTATAGAGATTTCTTTCGAGACATCTCCAAAATCTTCTGCTCTTCAGTGGCTCACT
CCTGAACAAACTTCTGGGAAAGAGCACCCCTATCTCTTTAGTCAGTGCCAGGCTATCCAC
TGTAGAGCTATTCTTCCTTGCCAGGACACTCCTTCCGTGAAATTAACCTACAGCGCAGAG
GTGTCTGTCCCCAAAGAACTGGTGGCACTTATGAGTGCCATTCGTGACGGAGAAGCACCT
GACCCAGAAGACCCGAACAGGAAAATTTACAGATTCAGCCAAAAAGTTCCAATCCCCTGC
TACCTGATTGCTTTGGTTGTTGGAGCTTTAGAAAGCAGACAGATTGGCCCAAGGACATTG
GTATGGTCCGAGAAAGAGCAGGTGGAAAAGTCTGCTTACGAATTTTCTGAGACTGAATCT
ATGCTTAAAATTGCAGAAGATCTGGGAGGCCCATATATTTGGGGGCAGTATGACCTATTG
GTCCTGCCGCCATCCTTTCCCTATGGCGGCATGGAGAACCCTTGCCTCACTTTTGTAACT
CCTACTCTGCTGGCTGGTGACAAGTCACTCTCCAATGTTATAGCACATGAAATATCTCAT
AGTTGGACAGGAAATCTAGTGACCAACAAAACTTGGGATCACTTTTGGTTAAATGAAGGA
CATACCGTATACTTGGAACGCCACATTTGTGGACGACTGTTTGGTGAAAAGTTTAGACAT
TTTCACGCTCTGGGCGGATGGGGAGAACTCCAGAATTCGATAAAGACTTTTGGGGAGACC
CATCCTTTCACCAAACTCGTGGTTGACCTGACGAACACAGACCCTGACGTGGCATATTCT
TCAGTTCCCTATGAGAAGGGCTTTGCTTTACTCTTTTACCTTGAACAGCTTCTTGGAGGA
CCAGAGGTTTTCCTAGGATTCTTAAAGGCTTATGTTGAGAAATTTTCCTACAAGAGCATA
ACTACTGATAACTGGAAGGATTTCTTGTATTCCCACTTTAAAGATAAGGTTGATATTCTC
AATCAAGTGGATTGGAACACCTGGCTGTACTCTCCTGGACTGCCCCCTGTAAAACCCAAT
TATGATATGACCCTGACAAATGCTTGCATTTCCTTGAGTCAAAGATGGATCACTGCCAAA
GATGATGATTTAAATTCATTCAGCTCAGCAGACCTAAAAGACTTCTCTTCCCATCAAGTG
AATGAATTTTTAGCACAGATGCTCCAGAATGCACCTCTTCCATTGGGGCACATAAAGCGA
ATGCAAGAGGTGTACAACTTCAATGCCATTAACAATTCTGAAATACGATTCAGATGGTTA
CGACTCTGCATTCAATCGAAATGGGAGGAAGCAATTCCTTTGGCTCTAAAAATGGCAACT
GAACAAGGAAGGATGAAGTTTACACGGCCCTTATTCAAGGACCTTGCTGCCTTTGACAAA
TCCCATGATCAAGCCATCCGTACCTACAAGGAGCACAAGGCATCCATGCACCCTGTGACT
GCCATGCTTGTGGGGAAAGATTTAAAAGTGGATTAA
Protein Properties
Number of Residues 611
Molecular Weight 69306.0
Theoretical pI 6.33
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence
>Leukotriene A-4 hydrolase
MPEVVDTCSLASPASVCQTKHLHLRCSIDFTRRVLSGTAALTIQSQEDNLRSLILDTKDL
TIEKVVINGQEVKYTLGERQSYKGSPIEISLPIALCKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYSAEVSVPKELVALMSAIRDGEAP
DPEDPNRKIYRFSQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYIWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNSIKTFGET
HPFTKLVVDLTNTDPDVAYSSVPYEKGFALLFYLEQLLGGPEVFLGFLKAYVEKFSYKSI
TTDNWKDFLYSHFKDKVDILNQVDWNTWLYSPGLPPVKPNYDMTLTNACISLSQRWITAK
DDDLNSFSSADLKDFSSHQVNEFLAQMLQNAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAIRTYKEHKASMHPVT
AMLVGKDLKVD
GenBank ID Protein AAI02853.1
UniProtKB/Swiss-Prot ID Q3SZH7
UniProtKB/Swiss-Prot Entry Name LKHA4_BOVIN
PDB IDs
GenBank Gene ID BC102852
GeneCard ID LTA4H
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available