| Identification |
|---|
| BMDB Protein ID
| BMDBP00615 |
| Secondary Accession Numbers
| |
| Name
| Pyruvate carboxylase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| PC |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate (By similarity). |
| Pathways
|
- Carbohydrate biosynthesis
- Gluconeogenesis
|
| Reactions
|
| Adenosine triphosphate + Pyruvic acid + Hydrogen carbonate → ADP + Hydrogen phosphate + Oxalacetic acid |
details
|
| 3-Methylcrotonyl-CoA + Adenosine triphosphate + Hydrogen carbonate → 3-Methylglutaconyl-CoA + ADP |
details
|
| Propionyl-CoA + Adenosine triphosphate + Hydrogen carbonate → S-Methylmalonyl-CoA + ADP + Hydrogen phosphate |
details
|
| Propionyl-CoA + Hydrogen carbonate + Adenosine triphosphate → S-Methylmalonyl-CoA + ADP + Hydrogen |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 29 |
| Locus
| Not Available |
| SNPs
| PC |
| Gene Sequence
|
>3537 bp
ATGCTGAAGTTTCAGACTGTCCGGGGGAGCCTGAGGCTCCTGGCTATCCGCCGGACCTCC
ACCGCAACCGCTGCCTCTCCCAATGTCCGGCGCCTGGAGTACAAGCCCATCAAGAAGGTC
ATGGTGGCCAACAGAGGCGAGATCGCCATCCGTGTGTTCCGGGCCTGCACGGAGCTGGGC
ATCCGCACGGTGGCTGTCTACTCGGAGCAGGACACGGGCCAAATGCACCGACAGAAAGCT
GACGAAGCCTACCTCATCGGCCGGGGTCTTGCCCCGGTGCAGGCCTATCTGCACATTCCA
GACATCATTAAGGTCGCCAAGGAGAACAACGTGGACGCTGTGCACCCGGGCTACGGGTTC
CTGTCGGAGCGGGCCGACTTTGCCCAGGCCTGCCAGGATGCTGGGGTCCGGTTCATTGGG
CCAAGCCCCGAGGTGGTCCGCAAGATAGGTGACAAGGTGGAGGCCCGGACCATCGCCATC
GCCGCAGATGTGCCCGTGGTGCCCGGCACGAATGCCCCCATCACTTCCCTGCACGAGGCC
CACGAGTTCTCCAACACCTACGGCTTCCCCATCATCTTCAAGGCCGCCTACGGGGGCGGG
GGCCGCGGCATGAGGGTCGTGCACAGCTACGAGGAGCTGGAGGAGAACTACACCCGGGCC
TACTCGGAGGCTCTGGCCGCCTTCGGGAACGGGGCGCTGTTCGTGGAGAAGTTCATCGAG
AAGCCACGCCACATCGAGGTGCAGATCCTGGGGGACCAGTACGGGAACATCCTTCACCTC
TACGAGCGGGACTGCTCCATCCAGCGGCGGCACCAGAAAGTGGTGGAGATCGCCCCGGCT
GCCCACTTGGACCCCCAGCTGCGCACCCGGCTCACTAGCGACTCCGTCAAGCTTGCAAAG
CAGGTGGGCTACGAGAACGCGGGCACCGTGGAGTTCCTGGTGGACAGGCACGGCAAGCAC
TACTTCATCGAGGTCAACTCGCGCCTGCAGGTGGAGCACACGGTGACCGAGGAGATCACA
GATGTGGACCTGGTCCACGCCCAGATCCACGTGGCCGAGGGCCGGAGCCTGCCTGACCTG
GGCCTCCGGCAGGAGAACATCCGCATCAACGGCTGTGCCATCCAGTGCCGGGTTACCACC
GAGGACCCTGCGCGCAGCTTCCAGCCCGACACCGGCCGCATCGAGGTGTTCCGGAGCGGG
GAGGGCATGGGCATCCGCCTGGACAACGCCTCTGCCTTCCAAGGCGCCGTCATCTCCCCC
CACTACGACTCCCTGCTGGTCAAGGTCATCGCTCACGGCAAGGACCACCCCACGGACGCC
ACCAAGATGAGCAGAGCCCTGGCCGAGTTCCGAGTCCGAGGCGTGAAGACCAACATCCCC
TTCCTGCAGAACGTGCTCAACAACCAGCAGTTCCTGGCAGGCACCGTGGACACGCAGTTC
ATCGACGAGAACCCAGAGCTGTTCCAGCTGCGGCCCGCACAGAACCGGGCCCAGAAGCTG
CTGCACTACCTCGGACACGTCATGGTGAATGGCCCAACTACTCCGATCCCCGTCAAGGCC
AGCCCCAGCCCCACGGACCCCATCGTCCCTGTGGTGCCCATAGGCCCACCCCCAACGGGT
TTCAGAGACATCCTGCTACGGGAGGGGCCCGAGGGCTTTGCTCGAGCGGTGCGGAACCAT
GAGGGGCTGCTGCTGATGGACACGACCTTCAGGGACGCCCACCAGTCACTGCTGGCCACT
CGAGTGCGCACCCACGATCTCAAAAAGATCTCCCCCTATGTTGCCCACAGCTTCAACAAA
CTCTTCAGCATAGAGAACTGGGGAGGAGCCACCTTTGACGTCGCCATGCGCTTCCTGTAC
GAGTGCCCCTGGCGACGGCTGCAGGAGCTCCGGGAGCTCGTCCCCAACATCCCATTCCAG
ATGCTGCTGCGGGGGGCCAACGCCGTGGGCTACACCAACTACCCCGACAATGTGGTCTTC
AAGTTCTGCGAGGTGGCCAAGGAGAATGGCATGGACATCTTCCGGGTCTTTGACTCCCTC
AACTACCTGCCCAACCTGCTGCTGGGCATGGAGGCGGCGGGCAGTGCTGGTGGCGTGGTG
GAGGCCGCCATCTCCTACACGGGTGACGTGTCCGACCCCAGCCGCACCAAGTACTCGCTG
CAGTACTACATGGGCTTGGCCGAGGAGCTGGTGCGAGCCGGCACCCACATCCTGTGCATC
AAGGACATGGCTGGGCTGCTGAAGCCTACGGCCTGCACCATGCTGGTCAGCTCCCTCCGG
GACCGCTTCCCTGACCTCCCGCTGCACATCCACACCCACGACACGTCAGGGGCGGGCGTG
GCAGCCATGCTGGCCTGTGCTCACGCAGGGGCTGACGTGGTGGATGTGGCGGCTGACTCC
ATGTCTGGAATGACATCACAGCCCAGCATGGGGGCCCTGGTGGCCTGTACCCGAGGGACG
CCCCTGGACACAGGCGTGCCCCTGGAGCGTGTGTTCGACTACAGCGAGTACTGGGAGGGG
GCCCGGGGGCTGTACGCGGCCTTTGACTGCACGGCCACCATGAAGTCTGGCAACTCGGAC
GTGTATGAGAACGAGATCCCAGGGGGCCAGTACACCAACCTGCACTTCCAGGCGCACAGC
ATGGGGCTCGGCTCCAAGTTCAAGGAGGTCAAGAAGGCCTACGTGGAGGCCAACCAGATG
CTGGGCGACCTCATCAAGGTGACGCCCTCCTCCAAGATCGTGGGGGACCTGGCCCAGTTC
ATGGTGCAGAACGGGCTGACCCGAGCTGAGGCCGAAGCGCAGGCAGAGGAGCTGTCCTTC
CCCCGCTCGGTGGTGGAGTTCCTGCAGGGCTACATCGGCATCCCCCACGGGGGCTTCCCA
GAGCCCCTTCGCTCCAAGGTGCTGAAAGACCTGCCGAGGGTGGAGGGCCGGCCAGGAGCC
TCCCTCCCACCCCTGGACCTGCAGGCGCTGGAGAAGGAGCTGACGGAACGGCACGGGGAG
GAGGTGACCCCGGAGGACGTGCTCTCAGCCGCCATGTACCCCGACGTCTTTGCCCACTTC
AAGGACTTCACTGCCACCTTCGGCCCCCTGGACAGCCTCAATACGCGCCTCTTCCTGCAG
GGACCCAAGATTGCAGAGGAGTTTGAGGTGGAGCTGGAGCGAGGCAAGACGCTGCACATC
AAAGCCTTGGCCATAAGTGACCTCAACCGGGCGGGCCAGAGGCAGGTCTTCTTCGAGCTC
AACGGACAGCTGCGGTCCATCCTGGTCAAGGACACCCAGGCCATGAAGGAGATGCACTTC
CACCCCAAGGCCCTGAAGGACGTCAAGGGCCAGATTGGGGCACCCATGCCCGGGAAGGTG
ATAGACATCAAGGTGGCAGCAGGGGCCAAGGTGACCAAGGGCCAACCCCTGTGTGTGCTC
AGCGCCATGAAGATGGAGACTGTAGTGACCTCGCCCGTGGAGGGCACTGTCCGCAAGGTC
CACGTGACTAAGGACATGACGCTGGAGGGTGACGACCTCATCCTGGAGATCGAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1178 |
| Molecular Weight
| 129698.0 |
| Theoretical pI
| 6.83 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Pyruvate carboxylase, mitochondrial
MLKFQTVRGSLRLLAIRRTSTATAASPNVRRLEYKPIKKVMVANRGEIAIRVFRACTELG
IRTVAVYSEQDTGQMHRQKADEAYLIGRGLAPVQAYLHIPDIIKVAKENNVDAVHPGYGF
LSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDAPITSLHEA
HEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIE
KPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEIAPAAHLDPQLRTRLTSDSVKLAK
QVGYENAGTVEFLVDRHGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHVAEGRSLPDL
GLRQENIRINGCAIQCRVTTEDPARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISP
HYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKTNIPFLQNVLNNQQFLAGTVDTQF
IDENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVKASPSPTDPIVPVVPIGPPPTG
FRDILLREGPEGFARAVRNHEGLLLMDTTFRDAHQSLLATRVRTHDLKKISPYVAHSFNK
LFSIENWGGATFDVAMRFLYECPWRRLQELRELVPNIPFQMLLRGANAVGYTNYPDNVVF
KFCEVAKENGMDIFRVFDSLNYLPNLLLGMEAAGSAGGVVEAAISYTGDVSDPSRTKYSL
QYYMGLAEELVRAGTHILCIKDMAGLLKPTACTMLVSSLRDRFPDLPLHIHTHDTSGAGV
AAMLACAHAGADVVDVAADSMSGMTSQPSMGALVACTRGTPLDTGVPLERVFDYSEYWEG
ARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQM
LGDLIKVTPSSKIVGDLAQFMVQNGLTRAEAEAQAEELSFPRSVVEFLQGYIGIPHGGFP
EPLRSKVLKDLPRVEGRPGASLPPLDLQALEKELTERHGEEVTPEDVLSAAMYPDVFAHF
KDFTATFGPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAISDLNRAGQRQVFFEL
NGQLRSILVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVAAGAKVTKGQPLCVL
SAMKMETVVTSPVEGTVRKVHVTKDMTLEGDDLILEIE
|
| External Links |
|---|
| GenBank ID Protein
| AAO27903.1 |
| UniProtKB/Swiss-Prot ID
| Q29RK2 |
| UniProtKB/Swiss-Prot Entry Name
| PYC_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY185595 |
| GeneCard ID
| PC |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
