| Identification |
|---|
| BMDB Protein ID
| BMDBP00617 |
| Secondary Accession Numbers
| None |
| Name
| Phosphoenolpyruvate carboxykinase, cytosolic [GTP] |
| Synonyms
|
Not Available
|
| Gene Name
| PCK1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate. |
| Pathways
|
- Carbohydrate biosynthesis
- Gluconeogenesis
- Pyruvate Metabolism
|
| Reactions
|
| Guanosine triphosphate + Oxalacetic acid → Guanosine diphosphate + Phosphoenolpyruvic acid + Carbon dioxide |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 13 |
| Locus
| Not Available |
| SNPs
| PCK1 |
| Gene Sequence
|
>1869 bp
ATGCCTCCTCAGCTCTCAGACGGCCTCAACTACTCAGCCAAAATCGTCCGGGGCTCCCTG
GACAGCCTGCCCCAGGCCGTGAGGAGTTTCGTGGAGAGCAGCGCCAAGCTGTGCCGGCCT
GACCAAGTCCACATCTGCGATGGCTCCGAGGAGGAGAACCGGCAGCTGCTGAGCCACATG
GAGGAGGAGGGTGTGATCAAGAGGCTGAAGAAGTATGACAACTGCTGGTTGGCTCTCACT
GACCCCAGGGATGTGGCCAGAATTGAAAGCAAGACGGTCATCATCACTCGAGAGCAAAGA
GATACGGTGCCCATCCCCAAAAACGGCCTCAGTCAGCTGGGCCGCTGGATGTCCGAGGAG
GATTTTGAAAAAGCATTCAACATCCGATTTCCGGGGTGCATGAAGGGTCGCACCATGTAT
GTCATCCCGTTCAGCATGGGGCCCCTGGGCTCTCCTCTGTCCAAGATTGGCATCGAGCTG
ACAGACTCGCCCTACGTGGTGACCAGCATGCGCATCATGACGAGGATGGGCACCAGCGTC
CTGGAAGCGCTGGGGGACGGCGAGTTCGTCAAGTGCCTCCACTCCGTGGGGTGCCCTTTG
CCTTTAAAAAAGCCTTTGGTTAACAACTGGGCCTGTAACCCCGAGCTCACACTCATCGCC
CACCTGCCCGACCGCCGAGAAATCATCTCCTTTGGGAGTGGGTACGGCGGGAACTCGCTC
CTTGGGAAGAAGTGCTTTGCCCTCAGGATGGCCAGCCGGCTGGCCAAGGAGGAGGGGTGG
CTGGCAGAGCACATGCTGATTCTGGGCATCACCAACCCCAAGGGCCAGAAGAAGTACTTC
GCGGCTGCGTTTCCCAGCGCCTGTGGGAAGACCAACCTGGCCATGATGAACCCTACTCTC
CCGGGATGGAAAGTAGAGTGTGTGGGTGATGATATCGCCTGGATGAAATTTGACCAACAA
GGTAACTTGCGGGCCATCAATCCAGAGAATGGGTTTTTTGGCGTCGCTCCGGGAACCTCT
GTGAGGACAAATCCCAACGCCATCAAGACCATCCAGAAGAATACCATCTTCACCAACGTG
GCCGAGACCAGTGACGGGGGCGTTTACTGGGAAGGCATTGATCAGCCGCTGGCCGCACGA
GTCAAGCTCATTTCCTGGAAGGGCAAGGAGTGGGACCCCAAGGATGGGGAGCCTTGTGCC
CACCCCAACTCACGGTTCTGCACTCCAGCCAGCCAGTGCCCCATCATTGACCCTGACTGG
GAGTCTCCAGAGGGCGTGCCCATTGAGGGCATCATCTTCGGAGGGCGCCGGCCTGTTGGT
GTCCCTCTGGTCTACGAGGCTCTCAGCTGGCAGCACGGTGTGTTTGTGGGGGCGGCCATG
AGATCTGAGGCCACGGCAGCGGCGGAGTACAAGGGCAAAGTCATCATGCACGACCCCTTC
GCCATGGGCCCCTTCTTCGGCTACAACTTCGGCCAGTACCTGGCACACTGGCTCAGCATG
GCCCAGCGCCCCGCAGCCAAGCTGCCCAAGATCTTCCATGTCAACTGGTTCCGAAAGGAC
AAGGCCGGCAGGTTCCTCTGGCCCGGCTTCGGCGAGAACTCCCGGGTGCTGGAGTGGATG
TTCAACCGCGTGGTCGGGGAAGGCGGCGCAAGCGTCACGCCCATCGGCTACATCCCCGAT
GAGGATGCCCTGGACCTCCGGGGCCTGGGGGATGTCGACGTGAAGGAGCTCTTCCACATC
TCCAAGGAGTTCTGGGAGGAGGAGGTGGAGGAAATACAGAAGTACCTTGAGGAGCAAGTG
AACGTCGATCTACCCCCAGAGATCAAGAATCAGGTCCTGGCCCTGAAGCAGAGAATCAGC
CAGATGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 622 |
| Molecular Weight
| 69353.0 |
| Theoretical pI
| 6.73 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
MPPQLSDGLNYSAKIVRGSLDSLPQAVRSFVESSAKLCRPDQVHICDGSEEENRQLLSHM
EEEGVIKRLKKYDNCWLALTDPRDVARIESKTVIITREQRDTVPIPKNGLSQLGRWMSEE
DFEKAFNIRFPGCMKGRTMYVIPFSMGPLGSPLSKIGIELTDSPYVVTSMRIMTRMGTSV
LEALGDGEFVKCLHSVGCPLPLKKPLVNNWACNPELTLIAHLPDRREIISFGSGYGGNSL
LGKKCFALRMASRLAKEEGWLAEHMLILGITNPKGQKKYFAAAFPSACGKTNLAMMNPTL
PGWKVECVGDDIAWMKFDQQGNLRAINPENGFFGVAPGTSVRTNPNAIKTIQKNTIFTNV
AETSDGGVYWEGIDQPLAARVKLISWKGKEWDPKDGEPCAHPNSRFCTPASQCPIIDPDW
ESPEGVPIEGIIFGGRRPVGVPLVYEALSWQHGVFVGAAMRSEATAAAEYKGKVIMHDPF
AMGPFFGYNFGQYLAHWLSMAQRPAAKLPKIFHVNWFRKDKAGRFLWPGFGENSRVLEWM
FNRVVGEGGASVTPIGYIPDEDALDLRGLGDVDVKELFHISKEFWEEEVEEIQKYLEEQV
NVDLPPEIKNQVLALKQRISQM
|
| External Links |
|---|
| GenBank ID Protein
| AAN61102.1 |
| UniProtKB/Swiss-Prot ID
| Q8HYZ4 |
| UniProtKB/Swiss-Prot Entry Name
| PCKGC_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY145503 |
| GeneCard ID
| PCK1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
