Showing Protein Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (BMDBP00617)
| Identification | |||
|---|---|---|---|
| BMDB Protein ID | BMDBP00617 | ||
| Secondary Accession Numbers | None | ||
| Name | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | ||
| Synonyms | Not Available | ||
| Gene Name | PCK1 | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Energy production and conversion | ||
| Specific Function | Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate. | ||
| Pathways |
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| Reactions |
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 13 | ||
| Locus | Not Available | ||
| SNPs | PCK1 | ||
| Gene Sequence |
>1869 bp ATGCCTCCTCAGCTCTCAGACGGCCTCAACTACTCAGCCAAAATCGTCCGGGGCTCCCTG GACAGCCTGCCCCAGGCCGTGAGGAGTTTCGTGGAGAGCAGCGCCAAGCTGTGCCGGCCT GACCAAGTCCACATCTGCGATGGCTCCGAGGAGGAGAACCGGCAGCTGCTGAGCCACATG GAGGAGGAGGGTGTGATCAAGAGGCTGAAGAAGTATGACAACTGCTGGTTGGCTCTCACT GACCCCAGGGATGTGGCCAGAATTGAAAGCAAGACGGTCATCATCACTCGAGAGCAAAGA GATACGGTGCCCATCCCCAAAAACGGCCTCAGTCAGCTGGGCCGCTGGATGTCCGAGGAG GATTTTGAAAAAGCATTCAACATCCGATTTCCGGGGTGCATGAAGGGTCGCACCATGTAT GTCATCCCGTTCAGCATGGGGCCCCTGGGCTCTCCTCTGTCCAAGATTGGCATCGAGCTG ACAGACTCGCCCTACGTGGTGACCAGCATGCGCATCATGACGAGGATGGGCACCAGCGTC CTGGAAGCGCTGGGGGACGGCGAGTTCGTCAAGTGCCTCCACTCCGTGGGGTGCCCTTTG CCTTTAAAAAAGCCTTTGGTTAACAACTGGGCCTGTAACCCCGAGCTCACACTCATCGCC CACCTGCCCGACCGCCGAGAAATCATCTCCTTTGGGAGTGGGTACGGCGGGAACTCGCTC CTTGGGAAGAAGTGCTTTGCCCTCAGGATGGCCAGCCGGCTGGCCAAGGAGGAGGGGTGG CTGGCAGAGCACATGCTGATTCTGGGCATCACCAACCCCAAGGGCCAGAAGAAGTACTTC GCGGCTGCGTTTCCCAGCGCCTGTGGGAAGACCAACCTGGCCATGATGAACCCTACTCTC CCGGGATGGAAAGTAGAGTGTGTGGGTGATGATATCGCCTGGATGAAATTTGACCAACAA GGTAACTTGCGGGCCATCAATCCAGAGAATGGGTTTTTTGGCGTCGCTCCGGGAACCTCT GTGAGGACAAATCCCAACGCCATCAAGACCATCCAGAAGAATACCATCTTCACCAACGTG GCCGAGACCAGTGACGGGGGCGTTTACTGGGAAGGCATTGATCAGCCGCTGGCCGCACGA GTCAAGCTCATTTCCTGGAAGGGCAAGGAGTGGGACCCCAAGGATGGGGAGCCTTGTGCC CACCCCAACTCACGGTTCTGCACTCCAGCCAGCCAGTGCCCCATCATTGACCCTGACTGG GAGTCTCCAGAGGGCGTGCCCATTGAGGGCATCATCTTCGGAGGGCGCCGGCCTGTTGGT GTCCCTCTGGTCTACGAGGCTCTCAGCTGGCAGCACGGTGTGTTTGTGGGGGCGGCCATG AGATCTGAGGCCACGGCAGCGGCGGAGTACAAGGGCAAAGTCATCATGCACGACCCCTTC GCCATGGGCCCCTTCTTCGGCTACAACTTCGGCCAGTACCTGGCACACTGGCTCAGCATG GCCCAGCGCCCCGCAGCCAAGCTGCCCAAGATCTTCCATGTCAACTGGTTCCGAAAGGAC AAGGCCGGCAGGTTCCTCTGGCCCGGCTTCGGCGAGAACTCCCGGGTGCTGGAGTGGATG TTCAACCGCGTGGTCGGGGAAGGCGGCGCAAGCGTCACGCCCATCGGCTACATCCCCGAT GAGGATGCCCTGGACCTCCGGGGCCTGGGGGATGTCGACGTGAAGGAGCTCTTCCACATC TCCAAGGAGTTCTGGGAGGAGGAGGTGGAGGAAATACAGAAGTACCTTGAGGAGCAAGTG AACGTCGATCTACCCCCAGAGATCAAGAATCAGGTCCTGGCCCTGAAGCAGAGAATCAGC CAGATGTAA |
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| Protein Properties | |||
| Number of Residues | 622 | ||
| Molecular Weight | 69353.0 | ||
| Theoretical pI | 6.73 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions | Not Available | ||
| Protein Sequence |
>Phosphoenolpyruvate carboxykinase, cytosolic [GTP] MPPQLSDGLNYSAKIVRGSLDSLPQAVRSFVESSAKLCRPDQVHICDGSEEENRQLLSHM EEEGVIKRLKKYDNCWLALTDPRDVARIESKTVIITREQRDTVPIPKNGLSQLGRWMSEE DFEKAFNIRFPGCMKGRTMYVIPFSMGPLGSPLSKIGIELTDSPYVVTSMRIMTRMGTSV LEALGDGEFVKCLHSVGCPLPLKKPLVNNWACNPELTLIAHLPDRREIISFGSGYGGNSL LGKKCFALRMASRLAKEEGWLAEHMLILGITNPKGQKKYFAAAFPSACGKTNLAMMNPTL PGWKVECVGDDIAWMKFDQQGNLRAINPENGFFGVAPGTSVRTNPNAIKTIQKNTIFTNV AETSDGGVYWEGIDQPLAARVKLISWKGKEWDPKDGEPCAHPNSRFCTPASQCPIIDPDW ESPEGVPIEGIIFGGRRPVGVPLVYEALSWQHGVFVGAAMRSEATAAAEYKGKVIMHDPF AMGPFFGYNFGQYLAHWLSMAQRPAAKLPKIFHVNWFRKDKAGRFLWPGFGENSRVLEWM FNRVVGEGGASVTPIGYIPDEDALDLRGLGDVDVKELFHISKEFWEEEVEEIQKYLEEQV NVDLPPEIKNQVLALKQRISQM |
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| External Links | |||
| GenBank ID Protein | AAN61102.1 | ||
| UniProtKB/Swiss-Prot ID | Q8HYZ4 | ||
| UniProtKB/Swiss-Prot Entry Name | PCKGC_BOVIN | ||
| PDB IDs | Not Available | ||
| GenBank Gene ID | AY145503 | ||
| GeneCard ID | PCK1 | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||