| Identification |
|---|
| BMDB Protein ID
| BMDBP00622 |
| Secondary Accession Numbers
| None |
| Name
| Trimethyllysine dioxygenase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| TMLHE |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Secondary metabolites biosynthesis, transport and catabolism |
| Specific Function
| Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML). |
| Pathways
|
- Amine and polyamine biosynthesis
- Carnitine biosynthesis
- Carnitine Synthesis
|
| Reactions
|
| N6,N6,N6-Trimethyl-L-lysine + Oxoglutaric acid + Oxygen → 3-Hydroxy-N6,N6,N6-trimethyl-L-lysine + Succinic acid + Carbon dioxide |
details
|
| 3-Dehydroxycarnitine + Oxoglutaric acid + Oxygen → L-Carnitine + Succinic acid + Carbon dioxide |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| X |
| Locus
| Not Available |
| SNPs
| TMLHE |
| Gene Sequence
|
>1266 bp
ATGTGGTGTCACAGGTTGTCCCACCTACAAAGCAGGCTCCAGGACCTGCTGAGGGGACGG
GTCACACGTTGGGCCCTTCAACAGTCCAACTTCAAAAGCTTATTTCCACTAGCCATCTAT
TGGCACCATACAGCCTCCAAGTCTCTGAATTGTGTTTGGCAGCAACATGAAGATCATTTT
GAACTGCAATATGCTAACAATGTGATGCGCTTTGATTATGTCTGGCTTCGAGACCACTGC
CGCTCAGCATCTTGCTACAACTCTAAGACTCACCAGCGCAGCCTAGACACTGCCAGCGTG
GATTTATGTATCCAGCCACAGACCATTCATCTGGATGAGACCACACTCTTTTTCACTTGG
CCAGATGGTCATGTGACTAGATATGATTTGGATTGGCTCATGAAAAACAGCTATGAAGGG
CAGAAACAAAAGGTCATCCAGCCTAGAATCTTATGGAATGCTGAAATCTACCAGCAAGCC
CAAGTTCCAGCTGTAGATTTCCAGACGTTCTTAGAAACCAAGGAGGGACTGAAGAACTTT
CTGCAGAACTTTCTGCTCTATGGAATTGCTTTTGTGGAAAATGTCCCTCCTACTCAGAAA
CACACAGAGAAGCTGGCAGAAAGGATCAGCTTGATCAGAGAAACCATCTATGGAAGGATG
TGGTTTTTCACTTCAGACTTCTCCAGAGGTGACACTGCATACACCAAGCTAGCTCTGGAT
CGGCACACTGACACCACCTATTTTCAAGAGCCCTGTGGCATTCAAGTGTTTCACTGTCTT
AAGCATGAAGGAACAGGTGGCAGGACACTGCTAGTTGATGGATTCTATGCAGCAGAACAA
GTACTTCAAAAGGCACCTGAGGAATTTGAACTCCTCAGTAAAGTGCCATTGAAGCATGAA
TATATTGAAAATGTTGGAGAATGTCAAAACCACATGATTGGGGTTGGGCCAGTCTTAAAT
ATCTACCCATGGAATAAAGAGCTCTATTTGATCAGGTACAACAACTATGACCGGGCTGTC
ATAAATACTGTACCTTATGATGTTGTCCATCGTTGGTATACAGCACACCGGACTCTAACC
AGAGAGTTGAGGAGGCCTGAGAATGAGTTTTGGGTCAAACTCAAGCCTGGCAAGGTACTA
TTTATAGACAACTGGCGTGTCCTACATGGCAGGGAATCCTTCACAGGCTACCGCCAACTC
TGTGGCTGCTATTTAACAAGGGATGATGTATTAAACACTGCTCGTCTCTTGGGCCTTCAG
GCTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 421 |
| Molecular Weight
| 49837.0 |
| Theoretical pI
| 7.97 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Trimethyllysine dioxygenase, mitochondrial
MWCHRLSHLQSRLQDLLRGRVTRWALQQSNFKSLFPLAIYWHHTASKSLNCVWQQHEDHF
ELQYANNVMRFDYVWLRDHCRSASCYNSKTHQRSLDTASVDLCIQPQTIHLDETTLFFTW
PDGHVTRYDLDWLMKNSYEGQKQKVIQPRILWNAEIYQQAQVPAVDFQTFLETKEGLKNF
LQNFLLYGIAFVENVPPTQKHTEKLAERISLIRETIYGRMWFFTSDFSRGDTAYTKLALD
RHTDTTYFQEPCGIQVFHCLKHEGTGGRTLLVDGFYAAEQVLQKAPEEFELLSKVPLKHE
YIENVGECQNHMIGVGPVLNIYPWNKELYLIRYNNYDRAVINTVPYDVVHRWYTAHRTLT
RELRRPENEFWVKLKPGKVLFIDNWRVLHGRESFTGYRQLCGCYLTRDDVLNTARLLGLQ
A
|
| External Links |
|---|
| GenBank ID Protein
| AAI20319.1 |
| UniProtKB/Swiss-Prot ID
| Q0VC74 |
| UniProtKB/Swiss-Prot Entry Name
| TMLH_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC120318 |
| GeneCard ID
| TMLHE |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
