| Identification |
|---|
| BMDB Protein ID
| BMDBP00625 |
| Secondary Accession Numbers
| None |
| Name
| Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| SUCLA2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. |
| Pathways
|
- Carbohydrate metabolism
- Succinate from succinyl-CoA (ligase route): step 1/1
- Tricarboxylic acid cycle
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| Not Available |
| SNPs
| SUCLA2 |
| Gene Sequence
|
>1392 bp
ATGGCGGCCTCCGTGTTCTACAGCCGGCTCTTGGCTGCCGCCACCCTGAGGAGCCACCGA
CCCCGAACGGCGCTGCCGGCCGCCGCCCAGGTCCTGGGAAGCTCTGGATTGTTTAACAAC
CATGGAGTCCAAATACAGCATCAACAGCAAAGGAATCTCTCGCTGCATGAATACCTGAGT
ATGGAATTGTTGCAGGAAGCTGGCGTCTCCATTCCCAAAGGACATGTGGCTAAGTCACCA
GATGAAGCTTATGCGATTGCCAAAAAATTAGGTTCAAAAGATGTTGTGATAAAGGCGCAA
GTTTTGGCTGGTGGCAGAGGAAAAGGAACATTTGAAAGTGGCCTCAAAGGAGGAGTGAAG
ATAGTTTTCTCTCCAGAAGAAGCAAAAGCTGTTTCCTCACAAATGATTGGGAAAAAGTTG
TTTACCAAGCAAACAGGAGAAAAGGGCAGGATATGCAATCAAGTATTGGTTTGTGAACGA
AGATATCCCAGGAGAGAATACTACTTTGCAATCACAATGGAAAGGTCATTTCAAGGTCCT
GTATTAATAGGAAGTTCTCACGGTGGTGTCAACATTGAAGATGTTGCTGCTGAGACTCCC
GAGGCCATAGTTAAAGAGCCTATCGATATCGTAGAAGGCATCAAAAAGGAACAAGCTGTC
CGGCTTGCACAGAAGATGGGATTTCCAGCCAGTATTGTGGATTCTGCAGCAGAAAACATG
ATCAAGCTTTATGACCCTTTTCTGAAATACGATGCAACCATGGTAGAAATAAATCCAATG
GTAGAGGATTCAGATGGAGCTGTGCTGTGTATGGATGCAAAGATCAATTTTGATTCTAAT
TCAGCTTATCGTCAGAAGAAAATCTTTGACCTGCAGGACTGGACCCAGGAAGATGAAAGG
GACAAAGATGCAGCTAAGGCAGATCTCAACTACATTGGCCTTGACGGAAATATCGGCTGT
CTAGTGAATGGTGCTGGTTTGGCTATGGCTACAATGGATATAATAAAACTCCATGGAGGG
ACTCCAGCCAACTTTCTTGATGTTGGTGGTGGTGCCACAGTCCATCAAGTAACAGAAGCG
TTTAAACTTATCACTTCAGATAAAAAGGTACTATCTATTTTGGTCAACATTTTTGGAGGA
ATCATGCGGTGTGACGTTATTGCACAGGGTATAGTCATGGCAGTAAAGGATTTGGAAATT
AAAATACCTATTGTGGTACGGTTACAAGGTACACGAGTTGATGATGCTAAGGCACTGATA
GCGGACAGTGGACTTAAAATCCTTGCTTGTGATGACTTGGATGAAGCTGCTAAAATGGTT
GTAAAGCTCTCTGAGATAGTGACCTTAGCCAAGCAAGCCCAGGTGGATGTGAAATTTCAG
TTGCCAATCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 463 |
| Molecular Weight
| 50130.0 |
| Theoretical pI
| 7.21 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial
MAASVFYSRLLAAATLRSHRPRTALPAAAQVLGSSGLFNNHGVQIQHQQQRNLSLHEYLS
MELLQEAGVSIPKGHVAKSPDEAYAIAKKLGSKDVVIKAQVLAGGRGKGTFESGLKGGVK
IVFSPEEAKAVSSQMIGKKLFTKQTGEKGRICNQVLVCERRYPRREYYFAITMERSFQGP
VLIGSSHGGVNIEDVAAETPEAIVKEPIDIVEGIKKEQAVRLAQKMGFPASIVDSAAENM
IKLYDPFLKYDATMVEINPMVEDSDGAVLCMDAKINFDSNSAYRQKKIFDLQDWTQEDER
DKDAAKADLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTEA
FKLITSDKKVLSILVNIFGGIMRCDVIAQGIVMAVKDLEIKIPIVVRLQGTRVDDAKALI
ADSGLKILACDDLDEAAKMVVKLSEIVTLAKQAQVDVKFQLPI
|
| External Links |
|---|
| GenBank ID Protein
| AAI18444.1 |
| UniProtKB/Swiss-Prot ID
| Q148D5 |
| UniProtKB/Swiss-Prot Entry Name
| SUCB1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC118443 |
| GeneCard ID
| SUCLA2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
