Showing Protein Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (BMDBP00626)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 6 metabolites
Identification
BMDB Protein ID BMDBP00626
Secondary Accession Numbers None
Name Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
Synonyms Not Available
Gene Name SUCLG1
Protein Type Enzyme
Biological Properties
General Function Energy production and conversion
Specific Function Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.
Pathways
  • Carbohydrate metabolism
  • Citric Acid Cycle
  • Succinate from succinyl-CoA (ligase route): step 1/1
  • Tricarboxylic acid cycle
  • Warburg Effect
Reactions
Succinyl-CoA + Hydrogen phosphate + Guanosine diphosphate → Succinic acid + Coenzyme A + Guanosine triphosphate details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 11
Locus Not Available
SNPs SUCLG1
Gene Sequence 
>1041 bp
ATGACCGCAGCCCTCGCTGCTGCCCGTGCCGCTGCGACCATGGCCTCTGGCAGCAGCGGC
CTCGCCGCCGCCCGCCTCCTGTCCCGCGCCTTCCTCTTGCAACAGAATGGAATTCGGCAT
TGCTCTTATACAACTTCCAGGAAGCATCTCTATGTTGATAGAAATACGAAGATTATTTGC
CAGGGTTTCACTGGTAAGCAGGGCACCTTTCATAGCCAGCAGGCACTGGAATATGGCACC
AAACTAGTTGGAGGAACCACTCCAGGGAAAGGAGGAAAGACGCACCTGGGCTTACCAGTC
TTTAACACTGTGAAGGAGGCCAAAGAACAGACTGGGGCGACAGCATCTGTCATTTATGTC
CCTCCTCCCTTTGCTGTTGCTGCCATTGATGAAGCTATCGAGGCGGAAGTGTCCCTGGTC
GTGTGCATCACCGAAGGTATCCCGCAGCAGGACATGGTGCGGGTCAAGCACAAACTGCTG
CGACAGGGAAAGACCAGGCTGGTCGGGCCGAACTGCCCTGGAGTCATCAATCCTGGAGAA
TGCAAAATTGGCATCATGCCTGGCCATATTCACAAGAAAGGAAGAGTCGGTATCGTGTCT
AGATCCGGCACCCTGACTTACGAAGCGGTTCACCAGACAACACAAGTTGGATTGGGGCAG
TCTTTGTGTGTTGGCATTGGAGGCGATCCTTTCAATGGAACAGACTTTACAGACTGCCTT
GAAATCTTTCTGAATGATCCGGCCACAGAAGGCATCATATTGATTGGTGAAATTGGTGGT
AATGCCGAAGAAAATGCTGCAGAATTTTTGAAGCAACATAATTCAGGTCCCAAGGCCAAG
CCTGTGGTGTCCTTCATTGCTGGTTTAACTGCTCCTCCCGGCAGAAGAATGGGTCACGCA
GGGGCAATCATTGCTGGAGGAAAAGGTGGAGCTAAAGAGAAGATCGCAGCCCTGCAGAGT
GCTGGGGTTGTGGTCAGCATGTCCCCAGCACAGCTGGGAACCACCATGTACAAGGAGTTT
GAAAAGAGGAAGATGCTCTGA
Protein Properties
Number of Residues 346
Molecular Weight 36167.0
Theoretical pI 9.83
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence 
>Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial
MTAALAAARAAATMASGSSGLAAARLLSRAFLLQQNGIRHCSYTTSRKHLYVDRNTKIIC
QGFTGKQGTFHSQQALEYGTKLVGGTTPGKGGKTHLGLPVFNTVKEAKEQTGATASVIYV
PPPFAVAAIDEAIEAEVSLVVCITEGIPQQDMVRVKHKLLRQGKTRLVGPNCPGVINPGE
CKIGIMPGHIHKKGRVGIVSRSGTLTYEAVHQTTQVGLGQSLCVGIGGDPFNGTDFTDCL
EIFLNDPATEGIILIGEIGGNAEENAAEFLKQHNSGPKAKPVVSFIAGLTAPPGRRMGHA
GAIIAGGKGGAKEKIAALQSAGVVVSMSPAQLGTTMYKEFEKRKML
GenBank ID Protein AAX46376.1
UniProtKB/Swiss-Prot ID Q58DR8
UniProtKB/Swiss-Prot Entry Name SUCA_BOVIN
PDB IDs
GenBank Gene ID BT021529
GeneCard ID SUCLG1
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available