Showing Protein Corticosteroid 11-beta-dehydrogenase isozyme 2 (BMDBP00630)
| Identification | |||
|---|---|---|---|
| BMDB Protein ID | BMDBP00630 | ||
| Secondary Accession Numbers | None | ||
| Name | Corticosteroid 11-beta-dehydrogenase isozyme 2 | ||
| Synonyms | Not Available | ||
| Gene Name | HSD11B2 | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Lipid transport and metabolism | ||
| Specific Function | Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Affinity towards corticosterone is higher than cortisol or dexamethasone. | ||
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| Reactions |
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 18 | ||
| Locus | Not Available | ||
| SNPs | HSD11B2 | ||
| Gene Sequence |
>1215 bp ATGGAAAGCTGGCCCTGGCCGTCGGGCGGCGCCTGGCTGCTCGTGCCGGCCCGTGCGCTA CTGCAGTTGCTGCGCGCAGACCTGCGTCTGGGCCGCCCGCTGTTGGCGGCGCTGGCGCTG CTGGCCGCGCTCGACTGGCTGTGCCAGCGCCTGCTACCCCCGCTGGCCGCACTTGCCGTG TTGGCCGCCACCGGCTGGATCGTGTTGTCCCGCCTGGCGCGCCCGCAGCGCCTGCCCGTG GCGACTCGCGCGGTGCTCATCACCGGCTGTGACTCTGGTTTTGGCAACGCGACGGCCAAG AAGCTTGACACCATGGGCTTCACAGTGTTGGCGACCGTGTTGGATCTGAATAGCCCTGGG GCCCTAGAGCTGCGTGCCTGCTGTTCTTCTCGTCTGAAGCTGCTACAGATGGACCTGACC AAGCCAGGAGACATTAGCCGTGTGTTGGAGTTCACCAAGGTCCACACGCCAAGCACAGGT CTGTGGGGCCTGGTCAACAACGCGGGCCAGAACATCTTTGTGGCGGATGCAGAGCTGTGT CCAGTGGCCACTTTCCGCACCTGCATGGAGGTGAACTTCTTTGGTGCACTAGAGATGACC AAAGGCCTCTTGCCACTGCTGCGTCGTTCAAGTGGTCGAATTGTGACCGTGAGCAGCCCA GCAGGAGACATGCCATTTCCATGCTTAGCTGCCTATGGGACCTCCAAAGCAGCCTTGGCG TTGCTCATGGGCAATTTTAGCTGTGAACTTCTGCCCTGGGGTGTCAAGGTCAGCATCATC CAGCCTGCCTGCTTCAAGACAGAGTCAGTGAAGGACGTGCACCAATGGGAAGAGCGCAAG CAGCAGCTGCTGGCCACCCTGCCTCAAGAGCTGCTGCAGGCCTATGGTGAGGACTACATC GAGCACTTGAATGGGCAGTTCCTGCACTCTCTGAGCCAGGCCCTGCCAGACCTCAGCCCT GTGGTAGATGCCATCACCGATGCGCTGCTGGCGGCCCAGCCACTCCGCCGCTATTACCCA GGTCATGGCCTGGGGCTCATATACTTCATCCACTACTACCTGCCCGAGGGTCTGCGGCAG CGTTTCCTGCAGTCCTTCTTCATCAGTCCCTATGTGCCGAGAGCACTACAGGCTGGCCAG CCTGGCCTTACCTCTGCCCGGGACATAGCCCAGGACCAAGGCCCTAGACCGGATCCTTCT CCCACTGCCCAGTGA |
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| Protein Properties | |||
| Number of Residues | 404 | ||
| Molecular Weight | 43987.0 | ||
| Theoretical pI | 8.32 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions | Not Available | ||
| Protein Sequence |
>Corticosteroid 11-beta-dehydrogenase isozyme 2 MESWPWPSGGAWLLVPARALLQLLRADLRLGRPLLAALALLAALDWLCQRLLPPLAALAV LAATGWIVLSRLARPQRLPVATRAVLITGCDSGFGNATAKKLDTMGFTVLATVLDLNSPG ALELRACCSSRLKLLQMDLTKPGDISRVLEFTKVHTPSTGLWGLVNNAGQNIFVADAELC PVATFRTCMEVNFFGALEMTKGLLPLLRRSSGRIVTVSSPAGDMPFPCLAAYGTSKAALA LLMGNFSCELLPWGVKVSIIQPACFKTESVKDVHQWEERKQQLLATLPQELLQAYGEDYI EHLNGQFLHSLSQALPDLSPVVDAITDALLAAQPLRRYYPGHGLGLIYFIHYYLPEGLRQ RFLQSFFISPYVPRALQAGQPGLTSARDIAQDQGPRPDPSPTAQ |
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| External Links | |||
| GenBank ID Protein | AAC26137.1 | ||
| UniProtKB/Swiss-Prot ID | O77667 | ||
| UniProtKB/Swiss-Prot Entry Name | DHI2_BOVIN | ||
| PDB IDs | Not Available | ||
| GenBank Gene ID | AF074706 | ||
| GeneCard ID | HSD11B2 | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||