| Identification |
|---|
| BMDB Protein ID
| BMDBP00630 |
| Secondary Accession Numbers
| None |
| Name
| Corticosteroid 11-beta-dehydrogenase isozyme 2 |
| Synonyms
|
Not Available
|
| Gene Name
| HSD11B2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Affinity towards corticosterone is higher than cortisol or dexamethasone. |
| Pathways
|
|
| Reactions
|
| Corticosterone + NADP → 11-Dehydrocorticosterone + NADPH |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| Not Available |
| SNPs
| HSD11B2 |
| Gene Sequence
|
>1215 bp
ATGGAAAGCTGGCCCTGGCCGTCGGGCGGCGCCTGGCTGCTCGTGCCGGCCCGTGCGCTA
CTGCAGTTGCTGCGCGCAGACCTGCGTCTGGGCCGCCCGCTGTTGGCGGCGCTGGCGCTG
CTGGCCGCGCTCGACTGGCTGTGCCAGCGCCTGCTACCCCCGCTGGCCGCACTTGCCGTG
TTGGCCGCCACCGGCTGGATCGTGTTGTCCCGCCTGGCGCGCCCGCAGCGCCTGCCCGTG
GCGACTCGCGCGGTGCTCATCACCGGCTGTGACTCTGGTTTTGGCAACGCGACGGCCAAG
AAGCTTGACACCATGGGCTTCACAGTGTTGGCGACCGTGTTGGATCTGAATAGCCCTGGG
GCCCTAGAGCTGCGTGCCTGCTGTTCTTCTCGTCTGAAGCTGCTACAGATGGACCTGACC
AAGCCAGGAGACATTAGCCGTGTGTTGGAGTTCACCAAGGTCCACACGCCAAGCACAGGT
CTGTGGGGCCTGGTCAACAACGCGGGCCAGAACATCTTTGTGGCGGATGCAGAGCTGTGT
CCAGTGGCCACTTTCCGCACCTGCATGGAGGTGAACTTCTTTGGTGCACTAGAGATGACC
AAAGGCCTCTTGCCACTGCTGCGTCGTTCAAGTGGTCGAATTGTGACCGTGAGCAGCCCA
GCAGGAGACATGCCATTTCCATGCTTAGCTGCCTATGGGACCTCCAAAGCAGCCTTGGCG
TTGCTCATGGGCAATTTTAGCTGTGAACTTCTGCCCTGGGGTGTCAAGGTCAGCATCATC
CAGCCTGCCTGCTTCAAGACAGAGTCAGTGAAGGACGTGCACCAATGGGAAGAGCGCAAG
CAGCAGCTGCTGGCCACCCTGCCTCAAGAGCTGCTGCAGGCCTATGGTGAGGACTACATC
GAGCACTTGAATGGGCAGTTCCTGCACTCTCTGAGCCAGGCCCTGCCAGACCTCAGCCCT
GTGGTAGATGCCATCACCGATGCGCTGCTGGCGGCCCAGCCACTCCGCCGCTATTACCCA
GGTCATGGCCTGGGGCTCATATACTTCATCCACTACTACCTGCCCGAGGGTCTGCGGCAG
CGTTTCCTGCAGTCCTTCTTCATCAGTCCCTATGTGCCGAGAGCACTACAGGCTGGCCAG
CCTGGCCTTACCTCTGCCCGGGACATAGCCCAGGACCAAGGCCCTAGACCGGATCCTTCT
CCCACTGCCCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 404 |
| Molecular Weight
| 43987.0 |
| Theoretical pI
| 8.32 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Corticosteroid 11-beta-dehydrogenase isozyme 2
MESWPWPSGGAWLLVPARALLQLLRADLRLGRPLLAALALLAALDWLCQRLLPPLAALAV
LAATGWIVLSRLARPQRLPVATRAVLITGCDSGFGNATAKKLDTMGFTVLATVLDLNSPG
ALELRACCSSRLKLLQMDLTKPGDISRVLEFTKVHTPSTGLWGLVNNAGQNIFVADAELC
PVATFRTCMEVNFFGALEMTKGLLPLLRRSSGRIVTVSSPAGDMPFPCLAAYGTSKAALA
LLMGNFSCELLPWGVKVSIIQPACFKTESVKDVHQWEERKQQLLATLPQELLQAYGEDYI
EHLNGQFLHSLSQALPDLSPVVDAITDALLAAQPLRRYYPGHGLGLIYFIHYYLPEGLRQ
RFLQSFFISPYVPRALQAGQPGLTSARDIAQDQGPRPDPSPTAQ
|
| External Links |
|---|
| GenBank ID Protein
| AAC26137.1 |
| UniProtKB/Swiss-Prot ID
| O77667 |
| UniProtKB/Swiss-Prot Entry Name
| DHI2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF074706 |
| GeneCard ID
| HSD11B2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
