| Identification |
|---|
| BMDB Protein ID
| BMDBP00633 |
| Secondary Accession Numbers
| None |
| Name
| Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe |
| Synonyms
|
Not Available
|
| Gene Name
| LFNG |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in O-fucosylpeptide 3-beta-N-acetylglucosaminy |
| Specific Function
| Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1. Decreases the binding of JAG1 to NOTCH2 but not that of DLL1. Essential mediator of somite segmentation and patterning. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 25 |
| Locus
| Not Available |
| SNPs
| LFNG |
| Gene Sequence
|
>1143 bp
ATGCTCAAGCGCTGCGGCCGCCGCCTGCTGCTGGCGCTGGCGGGCGCACTGCTTGCCTGC
CTACTGGTGCTCACGGCCGACCCGCCGCCGCCCCCGGTGCCCGCTGAACGCGGTCGGCGC
GCGCTGCGCAGCCTGGCGGGCCCCTCGGGGGTGGCCACGGCCCCTGGACTGGAGGCGGCG
GCGGCGGCGGCGCCCGGGGCGCCCGTCCGCGAGGTGCACAGTCTGTCCGAGTACTTCAGC
CTGCTCACCCGCTCTCGCAGAGACGTGGGCCCACCTCCCGGGGGCGCCCCCCGCCCCGCT
GACGGTCCTCCGCGGCCCCTGGCCGAGCCGCTGGCCCCACGCGACGTCTTCATCGCGGTG
AAGACCACCAAAAAGTTTCATCGCGCGCGTCTCGACTTGCTTCTGGAGACATGGATCTCG
CGCCACGAGGAGATGACGTTCATTTTCACGGACGGGGAAGACGAGGCACTGGCCAGGCGC
ACGGGCCACGTGGTCAACACCAACTGCTCGGCAGCCCACAGCCGCCAGGCACTGTCCTGC
AAGATGGCCGTGGAGTACGACCGCTTTATCGAGTCGGGGAGGAAGTGGTTCTGCCACGTG
GATGACGATAACTACGTGAATGTGCGGGCCCTGCTGAGGCTGCTGGGCAGTTACCCGCAC
ACGCAGGACGTCTACCTGGGCAAGCCCAGCCTGGACAGGCCCATCCAGGCCACGGAGCGG
GTCAGCGAAAACAAAGTGCGTCCTGTCCACTTCTGGTTTGCCACTGGCGGGGCTGGCTTC
TGCATCAGCCGAGGACTGGCCCTGAAGATGAGCCCCTGGGCCAGCGGAGGCCACTTCATG
AGCACGGCCGAGCGGATCCGGCTGCCTGACGACTGTACCATTGGCTACATCGTGGAGGCG
CTGCTGGGCGTGCCCCTCGTGCGCTGCGGGCTCTTCCACTCCCACCTGGAGAACCTGCAG
CAGGTGCCCGCCTCCGAGCTCCATGAGCAGGTGACCCTGAGCTACGGCATGTTTGAAAAC
AAGCGCAACTCCGTCCACATTAAGGGGCCCTTCTCGGTGGAGGCTGACCCGTCAAGGTTC
CGTTCCGTCCACTGCCACCTGTACCCGGACACGTCCTGGTGCCCCCGCTCTGCCATCTTC
TAG
|
| Protein Properties |
|---|
| Number of Residues
| 380 |
| Molecular Weight
| 41847.0 |
| Theoretical pI
| 8.84 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
MLKRCGRRLLLALAGALLACLLVLTADPPPPPVPAERGRRALRSLAGPSGVATAPGLEAA
AAAAPGAPVREVHSLSEYFSLLTRSRRDVGPPPGGAPRPADGPPRPLAEPLAPRDVFIAV
KTTKKFHRARLDLLLETWISRHEEMTFIFTDGEDEALARRTGHVVNTNCSAAHSRQALSC
KMAVEYDRFIESGRKWFCHVDDDNYVNVRALLRLLGSYPHTQDVYLGKPSLDRPIQATER
VSENKVRPVHFWFATGGAGFCISRGLALKMSPWASGGHFMSTAERIRLPDDCTIGYIVEA
LLGVPLVRCGLFHSHLENLQQVPASELHEQVTLSYGMFENKRNSVHIKGPFSVEADPSRF
RSVHCHLYPDTSWCPRSAIF
|
| External Links |
|---|
| GenBank ID Protein
| AAI05464.1 |
| UniProtKB/Swiss-Prot ID
| Q2KJ92 |
| UniProtKB/Swiss-Prot Entry Name
| LFNG_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC105463 |
| GeneCard ID
| LFNG |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
