Showing Protein 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (BMDBP00639)
| Identification | |||
|---|---|---|---|
| BMDB Protein ID | BMDBP00639 | ||
| Secondary Accession Numbers | None | ||
| Name | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase | ||
| Synonyms | Not Available | ||
| Gene Name | ACMSD | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Involved in aminocarboxymuconate-semialdehyde decarboxy | ||
| Specific Function | Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway (By similarity). | ||
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| Reactions |
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 2 | ||
| Locus | Not Available | ||
| SNPs | ACMSD | ||
| Gene Sequence |
>1011 bp ATGAAGATTGACATCCACACTCATATTTTACCAAGAGAATGGCCAGACCTAAAAAAGAGA TTCGGTTATGGAGGCTGGGTGCAGCTCCAACACAATGGCAAGGGAGAAGCAAAGATGCTG AAAGATGGGAAGGTCTTCAGAGTGGTCCAAGAGAACTGCTGGGATCCAGAAGCTCGTCTT AGAGAAATGGACCAAACAGGAGTGACTGTGCAAGCCCTTTCCACGGTTCCTGTCATGTTT AGCTACTGGGCCAAACCTCAGGACACTTTAGACCTGTGCCAGCTTCTGAACAACGACCTA GCCGCCACCATTGCGAGCCACCCCAGGAGGTTTGTGGGTCTGGGGACGTTGCCCATGCAG GCCCCTGAGCTGGCGGTTAAGGAGATGGAGCGCTGTGTGAGGAAGTTGGGCTTTCCCGGG GTTCAGATCGGCTCCCACATCAACGAGTGGGACCTGAACGCACGGGAACTCTTCCCAGTG TACGCGGAGGCTGAAAGGCTGAACTGTTCCCTATTTGTGCACCCCTGGGACATGCAGATG GATGGACGGATGGCCAAATACTGGTTCCCTTGGCTCATAGGAATGCCAGCTGAGACCACT GCAGCCATCTGTTCCATGATCATGGGTGGAGTGTTTGAGAAGTTTCCTAAACTGAAAGTG TGCTTTGCACATGGAGGTGGTTCCTTCCCCTTCACAGTTGGAAGAATCTCCCATGGATTC AGCATGCGTCCTGATCTGTGTGCACAGGACAATCCAACCAACCCAAAGAAATACCTTGGT TCCTTTTATACAGACTCCTTGGTTCATGATCCTCTGGCCCTCAAACTGTTAACAGATGTC ATAGGAAAGGATAAAGTCATTTTGGGAACTGATTACCCCTTCCCACTAGGTGAGTTGGAA CCTGGGAAACTGATAGAATCAATGGGAGAATTTGATGCAGAAACCAAGGATAAACTCAAA GCTGGCAATGCCCTAGAATTTTTGGGGCTTGAAAGGAAACAATTTGAATGA |
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| Protein Properties | |||
| Number of Residues | 336 | ||
| Molecular Weight | 37923.0 | ||
| Theoretical pI | 6.78 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions | Not Available | ||
| Protein Sequence |
>2-amino-3-carboxymuconate-6-semialdehyde decarboxylase MKIDIHTHILPREWPDLKKRFGYGGWVQLQHNGKGEAKMLKDGKVFRVVQENCWDPEARL REMDQTGVTVQALSTVPVMFSYWAKPQDTLDLCQLLNNDLAATIASHPRRFVGLGTLPMQ APELAVKEMERCVRKLGFPGVQIGSHINEWDLNARELFPVYAEAERLNCSLFVHPWDMQM DGRMAKYWFPWLIGMPAETTAAICSMIMGGVFEKFPKLKVCFAHGGGSFPFTVGRISHGF SMRPDLCAQDNPTNPKKYLGSFYTDSLVHDPLALKLLTDVIGKDKVILGTDYPFPLGELE PGKLIESMGEFDAETKDKLKAGNALEFLGLERKQFE |
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| External Links | |||
| GenBank ID Protein | AAI22782.1 | ||
| UniProtKB/Swiss-Prot ID | Q0II68 | ||
| UniProtKB/Swiss-Prot Entry Name | ACMSD_BOVIN | ||
| PDB IDs | Not Available | ||
| GenBank Gene ID | BC122781 | ||
| GeneCard ID | ACMSD | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||