Showing Protein Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (BMDBP00642)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00642 |
| Secondary Accession Numbers | None |
| Name | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform |
| Synonyms | Not Available |
| Gene Name | PPP2CA |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Signal transduction mechanisms |
| Specific Function | PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 7 |
| Locus | Not Available |
| SNPs | PPP2CA |
| Gene Sequence |
>930 bp ATGGACGAGAAGGTGTTCACCAAGGAGCTGGACCAGTGGATCGAGCAGCTGAACGAGTGC AAGCAGCTGTCTGAGTCCCAGGTTAAGAGCCTCTGCGAGAAGGCTAAAGAAATCCTGACA AAAGAATCCAATGTGCAAGAAGTTCGATGTCCAGTCACTGTCTGTGGAGATGTGCATGGG CAATTTCATGATCTCATGGAACTGTTTAGAATTGGTGGCAAATCACCAGATACAAATTAC TTGTTTATGGGCGATTATGTTGACAGAGGATATTATTCAGTGGAAACAGTTACTCTGCTT GTAGCTCTTAAGGTTCGTTACCGTGAACGTATCACCATTCTTCGAGGAAATCATGAGAGC AGACAGATCACACAAGTATATGGTTTCTACGATGAGTGTTTAAGGAAATACGGAAATGCA AATGTTTGGAAGTATTTTACAGACCTTTTTGACTATCTTCCTCTCACTGCCTTGGTGGAT GGGCAGATCTTCTGTCTACATGGTGGCCTCTCACCATCCATAGATACACTGGATCACATC AGAGCACTTGATCGCCTACAAGAAGTTCCTCATGAGGGTCCAATGTGTGACTTGCTGTGG TCAGATCCAGATGACCGTGGAGGTTGGGGTATATCTCCTCGAGGAGCTGGTTACACCTTT GGGCAGGATATTTCTGAGACATTTAATCATGCCAATGGCCTCACGTTGGTGTCTAGAGCT CATCAGCTGGTGATGGAGGGATATAACTGGTGCCATGACCGAAATGTAGTAACGATTTTC AGTGCTCCAAACTATTGTTATCGTTGTGGTAACCAAGCTGCAATCATGGAACTTGATGAT ACTCTAAAATACTCTTTCTTGCAGTTTGACCCAGCACCTCGCAGAGGCGAGCCACATGTT ACTCGTCGTACCCCAGACTACTTCCTGTAA |
| Protein Properties | |
| Number of Residues | 309 |
| Molecular Weight | 35594.0 |
| Theoretical pI | 5.22 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHG QFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHES RQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHI RALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRA HQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHV TRRTPDYFL |
| External Links | |
| GenBank ID Protein | CAA36789.1 |
| UniProtKB/Swiss-Prot ID | P67774 |
| UniProtKB/Swiss-Prot Entry Name | PP2AA_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | X52554 |
| GeneCard ID | PPP2CA |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |