Showing Protein Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (BMDBP00643)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 4 metabolites
Identification
BMDB Protein ID BMDBP00643
Secondary Accession Numbers None
Name Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Synonyms Not Available
Gene Name PPP1CA
Protein Type Enzyme
Biological Properties
General Function Signal transduction mechanisms
Specific Function Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E (By similarity). Dephosphorylates CENPA (By similarity). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (By similarity).
Pathways
  • Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
  • Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
  • Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
  • Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone
  • Intracellular Signalling Through Histamine H2 Receptor and Histamine
  • Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin
Reactions
Ethylene-responsive transcription factor ESR1 + Hydrogen phosphate → Ethylene-responsive transcription factor ESR1 details
Cyclic AMP-responsive element-binding protein 1 + Hydrogen phosphate → Cyclic AMP-responsive element-binding protein 1 details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 29
Locus Not Available
SNPs PPP1CA
Gene Sequence 
>993 bp
ATGTCCGACAGCGAGAAGCTCAACCTGGACTCTATAATCGGACGCCTGCTGGAAGTGCAG
GGCTCCAGGCCTGGAAAGAATGTACAGCTGACGGAGAACGAGATCCGTGGTCTGTGCCTC
AAATCCCGGGAGATTTTCCTGAGCCAGCCCATTCTTCTGGAGCTGGAGGCACCCCTCAAG
ATCTGCGGTGACATTCATGGCCAGTACTATGATCTTCTGCGGCTGTTCGAGTACGGTGGC
TTCCCTCCAGAGAGTAACTACTTGTTCCTGGGGGACTACGTGGACAGGGGCAAGCAGTCT
TTGGAGACCATCTGCCTGCTGCTGGCCTATAAGATCAAGTACCCAGAGAACTTCTTCCTG
CTCCGTGGGAACCACGAGTGTGCCAGCATCAACCGCATCTACGGCTTCTATGATGAGTGC
AAGAGACGCTACAACATCAAACTGTGGAAGACCTTCACTGATTGCTTCAACTGCCTGCCC
ATCGCTGCCATCGTGGACGAGAAGATCTTCTGTTGCCATGGAGGGCTGTCCCCAGACCTA
CAGTCCATGGAGCAGATCCGGCGTATCATGCGGCCCACAGATGTGCCTGACCAGGGCCTG
CTCTGTGACCTGCTGTGGTCTGACCCTGACAAGGACGTGCAGGGCTGGGGTGAGAATGAC
CGCGGCGTCTCCTTTACATTTGGAGCTGAGGTGGTGGCCAAGTTCCTGCACAAGCATGAC
CTGGACCTCATCTGCCGGGCACACCAGGTAGTAGAAGACGGCTATGAGTTCTTTGCCAAG
CGGCAGCTGGTGACACTCTTTTCAGCCCCCAACTACTGCGGCGAGTTTGACAATGCAGGT
GCCATGATGAGTGTGGACGAGACGCTCATGTGCTCCTTCCAGATCCTCAAGCCCGCTGAC
AAGAACAAGGGGAAATACGGGCAGTTCAGTGGCCTGAACCCTGGAGGCCGGCCCATCACC
CCACCCCGCAACTCCGCCAAAGCCAAGAAATAG
Protein Properties
Number of Residues 330
Molecular Weight 37512.0
Theoretical pI 6.25
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence 
>Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLK
ICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFL
LRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDL
QSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHD
LDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAD
KNKGKYGQFSGLNPGGRPITPPRNSAKAKK
GenBank ID Protein AAI02425.1
UniProtKB/Swiss-Prot ID Q3T0E7
UniProtKB/Swiss-Prot Entry Name PP1A_BOVIN
PDB IDs
GenBank Gene ID BC102424
GeneCard ID PPP1CA
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available