| Identification |
|---|
| BMDB Protein ID
| BMDBP00647 |
| Secondary Accession Numbers
| None |
| Name
| Serine/threonine-protein phosphatase 4 catalytic subunit |
| Synonyms
|
Not Available
|
| Gene Name
| PPP4C |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Signal transduction mechanisms |
| Specific Function
| Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase. In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 25 |
| Locus
| Not Available |
| SNPs
| PPP4C |
| Gene Sequence
|
>924 bp
ATGGCGGAGATCAGCGACCTGGACCGGCAGATCGAGCAGCTACGGCGCTGCGAGCTCATC
AAGGAGAGTGAAGTCAAAGCCCTGTGCGCTAAAGCCAGAGAGATCTTGGTGGAGGAAAGC
AACGTGCAGAGGGTGGACTCCCCAGTCACAGTGTGTGGTGACATCCATGGACAATTCTAT
GACCTCAAGGAGCTGTTCAGAGTGGGTGGCGATGTCCCTGAGACTAACTACCTCTTCATG
GGGGACTTTGTGGATCGTGGTTTCTACAGCGTCGAAACGTTTCTCCTGCTGCTGGCACTT
AAGGTTCGCTATCCTGACCGCATCACCCTGATCCGGGGCAACCATGAGAGCCGTCAGATC
ACCCAGGTCTACGGCTTCTATGACGAGTGTCTGCGCAAGTACGGCTCGGTGACCGTGTGG
CGCTACTGCACTGAGATCTTTGACTACCTCAGCCTGTCGGCCATCATCGATGGCAAGATC
TTCTGTGTGCATGGGGGGCTCTCCCCCTCCATCCAGACGCTGGACCAGATCCGGACAATT
GACCGAAAGCAAGAGGTGCCCCACGACGGGCCCATGTGTGACCTGCTCTGGTCCGACCCT
GAAGACACAACAGGCTGGGGCGTGAGCCCCCGTGGGGCCGGCTACCTGTTTGGCAGTGAC
GTGGTGGCCCAGTTCAACGCAGCCAACGACATTGACATGATCTGCCGTGCCCACCAACTG
GTGATGGAAGGTTACAAGTGGCACTTCAACGAGACTGTACTCACTGTGTGGTCGGCACCC
AACTACTGCTACCGCTGTGGGAATGTGGCAGCCATCTTGGAGCTGGATGAGCATCTCCAG
AAAGACTTCATCATCTTCGAGGCCGCTCCCCAAGAGACACGGGGCATCCCCTCCAAAAAG
CCCGTGGCCGACTACTTCCTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 307 |
| Molecular Weight
| 35080.0 |
| Theoretical pI
| 4.68 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Serine/threonine-protein phosphatase 4 catalytic subunit
MAEISDLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFY
DLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQI
TQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTI
DRKQEVPHDGPMCDLLWSDPEDTTGWGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQL
VMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQETRGIPSKK
PVADYFL
|
| External Links |
|---|
| GenBank ID Protein
| AAI46138.1 |
| UniProtKB/Swiss-Prot ID
| A6H772 |
| UniProtKB/Swiss-Prot Entry Name
| PP4C_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC146137 |
| GeneCard ID
| PPP4C |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
