| Identification |
|---|
| BMDB Protein ID
| BMDBP00651 |
| Secondary Accession Numbers
| None |
| Name
| Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| POMGNT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in alpha-1,3-mannosylglycoprotein 2-beta-N-ace |
| Specific Function
| Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose. |
| Pathways
|
- Protein glycosylation
- Protein modification
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| POMGNT1 |
| Gene Sequence
|
>1983 bp
ATGGACGACTGGAAGCCCAGCCCCCTCATCAAGCCCTTTGGGGCGCGAAAAAAGCGGAGC
TGGTATCTTACCTGGAAGTATAAACTGACCAACCAGCGGGCCCTGCGGAGGTTCTGTCAG
ACAGGAGCCGTGCTTTTCCTACTGGTGACCGTCATTGTCAACATCAAGTTGATCCTGGAC
ACACGACGAGCTATCAGCGAGGCCAGTGAAGACCTGGAGCCAGAACAAGACTATGATGAG
GCCCTGGGCCGATTGGAGCCTCCACGGCGCATAGGCAGTGGTCCCCGACGTGTCCTGGAT
GTGGAGGTATACTCAAGCCGCAGCAAAGTGTATGTGGCAGTGGACGGCACCACGGTGCTG
GAGGATGAGGCCCAGGAGCAGGGCCGGGGCATCCACGTCATCGTCCTCAACCAGGCCACG
GGCCATGTGATGGCAAAGCGAGTGTTTGACACCTATTCACCTCATGAGGATGAGGCCATG
GTGCTGTTCCTCAACATGGTGGCACCTGGCCGAGTGCTCATCTGCACCGTCAAGGACGAG
GGCTCCTTCCACCTCAAGGACACCGCCAAGGCTCTGCTGAGGAGCCTAGGCAGCCAGGCT
GGCCCTGCCCTGGGCTGGAGAGACACCTGGGCCTTCGTGGGACGAAAAGGAGGTCCTGTG
CTCGGGGAGAAACATTCTAAGTCACCTGCCCTCTCCTCCTGGGGGGATCCAGTTCTGCTG
AAGACAGATGTGCCGCTGAGCTCAGCTGAAGAGGCAGAGTGCCACTGGGCAGACACAGAG
CTGAACCGTCGCCGCCGCCGCTTCTGCAGCAAAGTTGAGGGCTATGGGAGCGTGTGCAGC
TGCAAGGACCCCACACCCATCGAGTTCAGCCCTGACCCACTCCCAGACAACAAGGTCCTC
AATGTGCCTGTGGCTGTCATTGCAGGGAACCGGCCCAATTACCTGTACAGGATGCTGCGC
TCTCTACTCTCAGCCCAGGGGGTGTCTCCCCAGATGATAACAGTTTTCATCGATGGCTAC
TATGAGGAGCCGATGGATGTGGTGGCGCTGTTTGGTCTGAGGGGCATCCAGCACACTCCC
ATCAGCATCAAGAACGCCCGTGTGTCTCAGCACTACAAGGCCAGCCTCACTGCCACTTTC
AACCTGTTTCCGGAAGCCAAGTTTGCTGTGGTTCTGGAAGAGGACCTGGACATTGCTGTG
GATTTTTTCAGTTTCCTGAGCCAATCCATCCACCTGCTGGAGGAGGACGACAGCTTGTAC
TGTATCTCTGCCTGGAATGACCAGGGCTATGAGCACACGGCAGAGGACCCAGCACTGCTA
TACCGTGTGGAGACCATGCCTGGGCTGGGCTGGGTGCTCAGGAAGTCCTTGTACAAGGAG
GAGCTTGAACCCAAGTGGCCCACACCAGAAAAGCTCTGGGACTGGGACATGTGGATGCGG
ATGCCGGAACAACGCCGAGGCCGAGAATGCATTATCCCTGACGTGTCCCGATCCTACCAC
TTCGGCATCGTTGGCCTCAACATGAATGGCTACTTCCATGAGGCCTACTTCAAGAAGCAC
AAGTTCAACACGGTTCCAGGTGTCCAGCTCAGGAACGTGGACAGTCTGAAGAAGGATGCT
TATGAAGTGGAAGTTCACAGGCTGCTCAGCGAAGCAGAGGTTCTGGACCACAGCAAGAAC
CCTTGTGAAGACTCTTTCCTGCCAGACACAGAGGGCCACACCTACGTGGCCTTTATCCGG
ATGGAGAAGGACGATGACTTCACCACCTGGACTCAGCTTGCCAAGTGCCTCCGAATCTGG
GACCTGGATGTGCGTGGCAACCACCGGGGCCTGTGGAGACTGTTTCGGAAGAAGAACCAC
TTCCTGGTGGTGGGGGTCCCAGCCTCCCCGTACTCGATGAAGAAGCCACCATCAATCACC
CCAATTTTCTTGGAGTCACCCCCAAAGGAGGAGGGAGGCCCAGGAGCTGCAGAACAGACA
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 660 |
| Molecular Weight
| 75077.0 |
| Theoretical pI
| 6.7 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1
MDDWKPSPLIKPFGARKKRSWYLTWKYKLTNQRALRRFCQTGAVLFLLVTVIVNIKLILD
TRRAISEASEDLEPEQDYDEALGRLEPPRRIGSGPRRVLDVEVYSSRSKVYVAVDGTTVL
EDEAQEQGRGIHVIVLNQATGHVMAKRVFDTYSPHEDEAMVLFLNMVAPGRVLICTVKDE
GSFHLKDTAKALLRSLGSQAGPALGWRDTWAFVGRKGGPVLGEKHSKSPALSSWGDPVLL
KTDVPLSSAEEAECHWADTELNRRRRRFCSKVEGYGSVCSCKDPTPIEFSPDPLPDNKVL
NVPVAVIAGNRPNYLYRMLRSLLSAQGVSPQMITVFIDGYYEEPMDVVALFGLRGIQHTP
ISIKNARVSQHYKASLTATFNLFPEAKFAVVLEEDLDIAVDFFSFLSQSIHLLEEDDSLY
CISAWNDQGYEHTAEDPALLYRVETMPGLGWVLRKSLYKEELEPKWPTPEKLWDWDMWMR
MPEQRRGRECIIPDVSRSYHFGIVGLNMNGYFHEAYFKKHKFNTVPGVQLRNVDSLKKDA
YEVEVHRLLSEAEVLDHSKNPCEDSFLPDTEGHTYVAFIRMEKDDDFTTWTQLAKCLRIW
DLDVRGNHRGLWRLFRKKNHFLVVGVPASPYSMKKPPSITPIFLESPPKEEGGPGAAEQT
|
| External Links |
|---|
| GenBank ID Protein
| AAX08670.1 |
| UniProtKB/Swiss-Prot ID
| Q5EAB6 |
| UniProtKB/Swiss-Prot Entry Name
| PMGT1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT020653 |
| GeneCard ID
| POMGNT1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
