| Identification |
|---|
| BMDB Protein ID
| BMDBP00662 |
| Secondary Accession Numbers
| |
| Name
| Tyrosinase |
| Synonyms
|
Not Available
|
| Gene Name
| TYR |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in copper ion binding |
| Specific Function
| This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. |
| Pathways
|
Not Available
|
| Reactions
|
| 2 Hydroquinone + Oxygen →2 Quinone +2 Water |
details
|
| Tyramine + Oxygen → Dopamine + Water |
details
|
| 2 L-Dopa + Oxygen →2 Dopaquinone +2 Water |
details
|
| L-Dopachrome + Oxygen → 5,6-Dihydroxyindole + Water |
details
|
| 5,6-Dihydroxyindole + Oxygen → Indole-5,6-quinone + Water |
details
|
| 2 5,6-Dihydroxyindole-2-carboxylic acid + Oxygen → Melanin + Water |
details
|
| Tyramine + Oxygen → L-Dopa + Water |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 29 |
| Locus
| 29qter |
| SNPs
| TYR |
| Gene Sequence
|
>1593 bp
ATGCTCCTGGCTGCCCTGTACTGCCTACTGTGGAGTTTCCGAACCTCCGCTGGCCACTTC
CCTCGAGCCTGTGCCTCCTCCAAGAGCCTGACGGAGAAGGAGTGCTGCCCGCCCTGGGCG
GGCGATGGGAGCCCCTGTGGCCGGCTCTCAGGCAGGGGCTCCTGCCAGGACGTCATTCTG
TCCACGGCACCACTCGGACCTCAGTTCCCCTTCACGGGGGTGGACGACCGCGAGTCTTGG
CCCTCCATCTTTTATAACAGAACCTGCCAGTGCTTTAGCAACTTCATGGGATTCAATTGC
GGAAGTTGTAAGTTTGGATTTAGGGGACCCCGCTGCACAGAAAGGCGACTTTTGGTGAGA
AGAAACATCTTTGATTTGAGTGTCCCAGAGAAGAACAAGTTTCTTGCCTATCTCACTTTG
GCAAAACATACCACCAGCCCAGACTACGTCATCCCCACGGGCACCTATGGCCAAATGAAT
CATGGAACAACACCCCTGTTTAATGACGTCAGTGTTTACGACCTCTTTGTCTGGATGCAT
TATTATGTGTCAAGGGACACGCTGCTTGGGGACTCTGAAGTCTGGAGAGACATTGATTTT
GCTCATGAAGCCCCAGGTTTCCTGCCTTGGCATAGACTCTTCCTGCTGCTGTGGGAACAG
GAAATCCAGAAGCTGACCGGGGATGAGAACTTCACGATTCCATACTGGGACTGGAGAGAT
GCAGAAAACTGTGACGTTTGCACAGATGAGTACATGGGAGGGCGCAACCCTGCAAACCCT
AATCTACTCAGCCCAGCATCCTTCTTCTCCTCTTGGCAGATCGTCTGCAGCAGACTGGAG
GAGTACAACAGTCGCCAGGCTTTATGCAACGGGACGTCTGAGGGACCATTACTGCGCAAT
CCTGGAAACCACGACAAAGCCAGGACCCCGAGGCTCCCCTCCTCGGCTGATGTGGAGTTT
TGCCTGAGTTTGACCCAGTATGAATCAGGTTCCATGGATAAAGCTGCCAATTTCAGCTTT
AGAAATACCCTGGAAGGATTTGCTGATCCAGTTACTGGGATAGCAGATGCCTCTCAAAGC
AGTATGCACAATGCCTTGCACATCTACATGAACGGAACGATGTCTCAGGTACCAGGATCT
GCCAATGATCCCATCTTCCTTCTTCATCACGCGTTTGTTGACAGTATTTTTGAACAGTGG
CTTCGAAAGTATCATCCTCTTCAAGATGTTTATCCAGAAGCTAATGCACCCATTGGGCAC
AACCGGGAATCCTACATGGTTCCTTTCATCCCTCTCTACAGAAACGGTGACTTCTTTATT
TCATCCAAAGATNTAGGCTACGACTATAGCTACCTACAAGATTCAGAACCGGACATTTTT
CAAGATTACATTAAGCCCTACTTAGAACAAGCGCAACGAATCTGGCCGTGGCTCATTGGG
GCAGCTGTGGTTGGGTCCGTCCTTACTGCTGTGCTGGGAGGACTTACTAGCCTGTTATGT
CGTCGAAAGAGAAACCAGCTTCCAGAAGAAAAGCAGCCCCTGCTCATGGAAAAAGAGGAT
TACCACAATTTGATGTATCAGAGCCATTTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 530 |
| Molecular Weight
| 60304.0 |
| Theoretical pI
| 5.71 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Tyrosinase
MLLAALYCLLWSFRTSAGHFPRACASSKSLTEKECCPPWAGDGSPCGRLSGRGSCQDVIL
STAPLGPQFPFTGVDDRESWPSIFYNRTCQCFSNFMGFNCGSCKFGFRGPRCTERRLLVR
RNIFDLSVPEKNKFLAYLTLAKHTTSPDYVIPTGTYGQMNHGTTPLFNDVSVYDLFVWMH
YYVSRDTLLGDSEVWRDIDFAHEAPGFLPWHRLFLLLWEQEIQKLTGDENFTIPYWDWRD
AENCDVCTDEYMGGRNPANPNLLSPASFFSSWQIVCSRLEEYNSRQALCNGTSEGPLLRN
PGNHDKARTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFADPVTGIADASQS
SMHNALHIYMNGTMSQVPGSANDPIFLLHHAFVDSIFEQWLRKYHPLQDVYPEANAPIGH
NRESYMVPFIPLYRNGDFFISSKDXGYDYSYLQDSEPDIFQDYIKPYLEQAQRIWPWLIG
AAVVGSVLTAVLGGLTSLLCRRKRNQLPEEKQPLLMEKEDYHNLMYQSHL
|
| External Links |
|---|
| GenBank ID Protein
| AAL02331.2 |
| UniProtKB/Swiss-Prot ID
| Q8MIU0 |
| UniProtKB/Swiss-Prot Entry Name
| TYRO_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY046527 |
| GeneCard ID
| TYR |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
