Showing Protein Tyrosinase (BMDBP00662)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 15 metabolites
Identification
BMDB Protein ID BMDBP00662
Secondary Accession Numbers
  • BMDBP03068
Name Tyrosinase
Synonyms Not Available
Gene Name TYR
Protein Type Enzyme
Biological Properties
General Function Involved in copper ion binding
Specific Function This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.
Pathways Not Available
Reactions
2 Hydroquinone + Oxygen →2 Quinone +2 Water details
Tyramine + Oxygen → Dopamine + Water details
2 L-Dopa + Oxygen →2 Dopaquinone +2 Water details
L-Dopachrome + Oxygen → 5,6-Dihydroxyindole + Water details
5,6-Dihydroxyindole + Oxygen → Indole-5,6-quinone + Water details
2 5,6-Dihydroxyindole-2-carboxylic acid + Oxygen → Melanin + Water details
Tyramine + Oxygen → L-Dopa + Water details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 29
Locus 29qter
SNPs TYR
Gene Sequence 
>1593 bp
ATGCTCCTGGCTGCCCTGTACTGCCTACTGTGGAGTTTCCGAACCTCCGCTGGCCACTTC
CCTCGAGCCTGTGCCTCCTCCAAGAGCCTGACGGAGAAGGAGTGCTGCCCGCCCTGGGCG
GGCGATGGGAGCCCCTGTGGCCGGCTCTCAGGCAGGGGCTCCTGCCAGGACGTCATTCTG
TCCACGGCACCACTCGGACCTCAGTTCCCCTTCACGGGGGTGGACGACCGCGAGTCTTGG
CCCTCCATCTTTTATAACAGAACCTGCCAGTGCTTTAGCAACTTCATGGGATTCAATTGC
GGAAGTTGTAAGTTTGGATTTAGGGGACCCCGCTGCACAGAAAGGCGACTTTTGGTGAGA
AGAAACATCTTTGATTTGAGTGTCCCAGAGAAGAACAAGTTTCTTGCCTATCTCACTTTG
GCAAAACATACCACCAGCCCAGACTACGTCATCCCCACGGGCACCTATGGCCAAATGAAT
CATGGAACAACACCCCTGTTTAATGACGTCAGTGTTTACGACCTCTTTGTCTGGATGCAT
TATTATGTGTCAAGGGACACGCTGCTTGGGGACTCTGAAGTCTGGAGAGACATTGATTTT
GCTCATGAAGCCCCAGGTTTCCTGCCTTGGCATAGACTCTTCCTGCTGCTGTGGGAACAG
GAAATCCAGAAGCTGACCGGGGATGAGAACTTCACGATTCCATACTGGGACTGGAGAGAT
GCAGAAAACTGTGACGTTTGCACAGATGAGTACATGGGAGGGCGCAACCCTGCAAACCCT
AATCTACTCAGCCCAGCATCCTTCTTCTCCTCTTGGCAGATCGTCTGCAGCAGACTGGAG
GAGTACAACAGTCGCCAGGCTTTATGCAACGGGACGTCTGAGGGACCATTACTGCGCAAT
CCTGGAAACCACGACAAAGCCAGGACCCCGAGGCTCCCCTCCTCGGCTGATGTGGAGTTT
TGCCTGAGTTTGACCCAGTATGAATCAGGTTCCATGGATAAAGCTGCCAATTTCAGCTTT
AGAAATACCCTGGAAGGATTTGCTGATCCAGTTACTGGGATAGCAGATGCCTCTCAAAGC
AGTATGCACAATGCCTTGCACATCTACATGAACGGAACGATGTCTCAGGTACCAGGATCT
GCCAATGATCCCATCTTCCTTCTTCATCACGCGTTTGTTGACAGTATTTTTGAACAGTGG
CTTCGAAAGTATCATCCTCTTCAAGATGTTTATCCAGAAGCTAATGCACCCATTGGGCAC
AACCGGGAATCCTACATGGTTCCTTTCATCCCTCTCTACAGAAACGGTGACTTCTTTATT
TCATCCAAAGATNTAGGCTACGACTATAGCTACCTACAAGATTCAGAACCGGACATTTTT
CAAGATTACATTAAGCCCTACTTAGAACAAGCGCAACGAATCTGGCCGTGGCTCATTGGG
GCAGCTGTGGTTGGGTCCGTCCTTACTGCTGTGCTGGGAGGACTTACTAGCCTGTTATGT
CGTCGAAAGAGAAACCAGCTTCCAGAAGAAAAGCAGCCCCTGCTCATGGAAAAAGAGGAT
TACCACAATTTGATGTATCAGAGCCATTTATGA
Protein Properties
Number of Residues 530
Molecular Weight 60304.0
Theoretical pI 5.71
Pfam Domain Function Not Available
Signals
  • 1-17
Transmembrane Regions
  • 474-494
Protein Sequence 
>Tyrosinase
MLLAALYCLLWSFRTSAGHFPRACASSKSLTEKECCPPWAGDGSPCGRLSGRGSCQDVIL
STAPLGPQFPFTGVDDRESWPSIFYNRTCQCFSNFMGFNCGSCKFGFRGPRCTERRLLVR
RNIFDLSVPEKNKFLAYLTLAKHTTSPDYVIPTGTYGQMNHGTTPLFNDVSVYDLFVWMH
YYVSRDTLLGDSEVWRDIDFAHEAPGFLPWHRLFLLLWEQEIQKLTGDENFTIPYWDWRD
AENCDVCTDEYMGGRNPANPNLLSPASFFSSWQIVCSRLEEYNSRQALCNGTSEGPLLRN
PGNHDKARTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFADPVTGIADASQS
SMHNALHIYMNGTMSQVPGSANDPIFLLHHAFVDSIFEQWLRKYHPLQDVYPEANAPIGH
NRESYMVPFIPLYRNGDFFISSKDXGYDYSYLQDSEPDIFQDYIKPYLEQAQRIWPWLIG
AAVVGSVLTAVLGGLTSLLCRRKRNQLPEEKQPLLMEKEDYHNLMYQSHL
GenBank ID Protein AAL02331.2
UniProtKB/Swiss-Prot ID Q8MIU0
UniProtKB/Swiss-Prot Entry Name TYRO_BOVIN
PDB IDs Not Available
GenBank Gene ID AY046527
GeneCard ID TYR
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available