Showing Protein 3-hydroxyanthranilate 3,4-dioxygenase (BMDBP00666)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 4 metabolites
Identification
BMDB Protein ID BMDBP00666
Secondary Accession Numbers None
Name 3-hydroxyanthranilate 3,4-dioxygenase
Synonyms Not Available
Gene Name HAAO
Protein Type Enzyme
Biological Properties
General Function Involved in 3-hydroxyanthranilate 3,4-dioxygenase activity
Specific Function Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
Pathways
  • Cofactor biosynthesis
  • NAD(+) biosynthesis
  • Quinolinate from L-kynurenine: step 3/3
  • Tryptophan Metabolism
  • Tyrosine Metabolism
Reactions
3-Hydroxyanthranilic acid + Oxygen → 2-Amino-3-carboxymuconic acid semialdehyde details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 11
Locus Not Available
SNPs HAAO
Gene Sequence 
>861 bp
ATGGAGCGCCCAGTGAGAGTGAAGGCGTGGGTGGAGGAGAACCGGGGCTCCTTCCTGCCC
CCGGTCTGCAACAAGCTCCTGCACCAGAAGCAGCTCAAAATCATGTTCGTGGGGGGTCCC
AACACCAGGAAGGACTACCACATCGAGGAGGGTGAGGAGGTATTTTACCAGCTGGAGGGG
GACATGCTTCTCCGAGTCCTGGAGCGAGGGAAACACCGGGATGTGGTCATTCGTCAGGGA
GAGATCTTCCTGCTGCCTGCTGGGGTCCCCCACTCGCCGCAGAGGTTTGCCAACACAGTG
GGGCTGGTGATTGAGCGGAGGCGGCTGAAAACAGAACTAGATGGGCTCAGGTACTACGTA
GGGGACACCACGGACGTCCTGTTTGAGAAGTGGTTCTACTGCGAGGACCTCGGCACGCAG
TTGGCCCCCATCATCCAGGAGTTCTTCAGCTCTGAGCAGTACAGAACGGGAAAGCCCAAC
CCTGACCAGCTGCTCAAGGAACCACCATTCCCCCTGAGCACACGATCCGTCATGGAGCCC
ATGTGCCTGGAGGCCTGGCTGGATGGCCACCGCAAAGAGCTGCAGGCGGGCACACCCCTC
AGCTTGTTTGGGGACACCTATGAGAGCCAGGTGATGGTCCACGGACAAGGCAGCAGCGAA
GGCCTGAGACGGGACGTGGACGTGTGGCTGTGGCAGCTGGAGGGCTCCTCAGTGGTGACG
ATGGAAGGACAGCGCCTGAGCCTGACCCTTGATGACAGCCTCCTGGTGCCAGCTGGGACT
CTGTATGGCTGGGAGCGAGGGCAAGGCTCCGTGGCCCTGTCTGTGACCCAGGATCCCGCC
TGCAAGAAGTCCCTGGGATGA
Protein Properties
Number of Residues 286
Molecular Weight 32493.0
Theoretical pI 5.45
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions
  • 28-Sep
Protein Sequence 
>3-hydroxyanthranilate 3,4-dioxygenase
MERPVRVKAWVEENRGSFLPPVCNKLLHQKQLKIMFVGGPNTRKDYHIEEGEEVFYQLEG
DMLLRVLERGKHRDVVIRQGEIFLLPAGVPHSPQRFANTVGLVIERRRLKTELDGLRYYV
GDTTDVLFEKWFYCEDLGTQLAPIIQEFFSSEQYRTGKPNPDQLLKEPPFPLSTRSVMEP
MCLEAWLDGHRKELQAGTPLSLFGDTYESQVMVHGQGSSEGLRRDVDVWLWQLEGSSVVT
MEGQRLSLTLDDSLLVPAGTLYGWERGQGSVALSVTQDPACKKSLG
GenBank ID Protein AAI20266.1
UniProtKB/Swiss-Prot ID Q0VCA8
UniProtKB/Swiss-Prot Entry Name 3HAO_BOVIN
PDB IDs
GenBank Gene ID BC120265
GeneCard ID HAAO
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available